What Happens to the Heart in Chronic Kidney Disease?

Rutherford, Elaine; Mark, Patrick B.

doi:10.4997/jrcpe.2017.117

Cited by 22 publications

(23 citation statements)

References 60 publications

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“…Around 10% of adults are affected by CKD specifically in older age groups and also CKD has a high connection with premature death as well as cardiovascular disease. 14–16 In CKD patients, there are no specific symptoms in early stages and symptoms are non-specific even in later stages. Eventually, CKD patients can develop into End-Stage Renal Disease (ESRD) that calls for kidney replacement therapies which include from chronic dialysis to kidney transplantation.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease

Hwang

2020

Eur J Inflamm

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Chronic kidney disease (CKD), characterized by the progressive, irreversible loss of kidney function, has been a significant socioeconomic burden. Thus, identifying potential treatment targets and incipient biological risk indicators for CKD prediction is crucial. Recently several studies revealed that IL-10, IL-10RA, and IL-10RB genes were involved in the development of vascular complications in hypertension and stroke. The purpose of this study was to evaluate the association between CKD and IL-10, IL-10RA, and IL-10RB gene polymorphisms in the Korean population. Ninety-two CKD patients and 312 control subjects participated in the study. Blood samples were drawn for biochemical measurements and genetic polymorphism analysis. To analyze the genotypes of each single nucleotide polymorphism (SNP), PCR products were sequenced by a DNA analyzer. The four SNPs of the IL-10RA gene showed significant associations between CKD and the control group in the codominant1 (rs2228054, rs2228055, and rs9610, OR = 0.48, 95% CI = 0.28–0.82, p = 0.007; rs2256111, OR = 0.49, 95% CI = 0.29–0.83, p = 0.008, respectively), dominant (rs2228054, rs2228055, and rs9610, OR = 0.59, 95% CI = 0.36–0.95, p = 0.028; rs2256111, OR = 0.60, 95% CI = 0.38–0.97, p = 0.037, respectively), and over-dominant model (rs2228054 and rs2228055, OR = 0.47, 95% CI = 0.28–0.79, p = 0.0034; rs9610, OR = 0.48, 95% CI = 0.29–0.80, p = 0.0037; rs2256111, OR = 0.49, 95% CI = 0.29–0.80, p = 0.0039). The four SNPs of IL-10 showed significant associations with the estimated glomerular filtration rate (eGFR) and C-reactive protein (CRP), with the minor homozygote genotype of each SNP associated with lower eGFRs and decreased CRP levels ( p < 0.05, p = 0.001, respectively). The two SNPs of IL-10RA showed significant associations with the CRP levels ( p < 0.05). The two SNPs of IL-10RB were significantly associated with the eGFR, with the minor homozygote genotype of each SNP associated with lower eGFRs ( p < 0.01). Our results show that IL-10RA gene variants are associated with CKD development. Additionally, this study suggests that SNPs of IL-10RA were associated with CRP levels in CKD.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease

Hwang

2020

Eur J Inflamm

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“…This vascular insult sets the cascade of atherosclerosis in motion, which in turn, is accelerated by the circulating cytokines in systemic inflammation [3]. ESRD also contributes to the development of MI by promoting myocardial fibrosis, ventricular dilation, and hypertrophy [4]. These are non-modifiable, but controllable risk factors.…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Bypass Graft in a Young Man

Pak¹

2017

Cureus

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Currently, there are no explicit guidelines on the management of acute myocardial infarction (MI) in young adults under the age of 30. The lack of published literature to guide clinicians in the care of young adults with MI has prompted us to report a case exemplary for the successful treatment with coronary artery bypass graft (CABG). A 25-year-old man developed acute MI and underwent on-pump five quintuple CABG using bilateral internal mammary arteries and left greater saphenous vein. This appropriate and timely intervention may have helped to prevent cardiac death and maintain the quality of life.

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“…The molecular, ultrastructural and geometric changes of the heart and vasculature collectively lead to reduced cardiac efficiency and hence increased myocardial energy expenditure and oxygen consumption. Unfortunately, cardiac remodeling occurs early in the course of CKD leading to left ventricular (LV) diastolic then systolic dysfunction and sudden cardiac death (Edwards et al, 2014;Rutherford and Mark, 2017).…”

Section: Integrative Physiology and The Fick Principle The Fick Princmentioning

confidence: 99%

Cardiovascular Functional Changes in Chronic Kidney Disease: Integrative Physiology, Pathophysiology and Applications of Cardiopulmonary Exercise Testing

et al. 2020

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The development of cardiovascular disease during renal impairment involves striking multi-tiered, multi-dimensional complex alterations encompassing the entire oxygen transport system. Complex interactions between target organ systems involving alterations of the heart, vascular, musculoskeletal and respiratory systems occur in Chronic Kidney Disease (CKD) and collectively contribute to impairment of cardiovascular function. These systemic changes have challenged our diagnostic and therapeutic efforts, particularly given that imaging cardiac structure at rest, rather than ascertainment under the stress of exercise, may not accurately reflect the risk of premature death in CKD. The multi-systemic nature of cardiovascular disease in CKD patients provides strong rationale for an integrated approach to the assessment of cardiovascular alterations in this population. State-of-the-art cardiopulmonary exercise testing (CPET) is a powerful, dynamic technology that enables the global assessment of cardiovascular functional alterations and reflects the integrative exercise response and complex machinery that form the oxygen transport system. CPET provides a wealth of data from a single assessment with mechanistic, physiological and prognostic utility. It is an underutilized technology in the care of patients with kidney disease with the potential to help advance the field of cardio-nephrology. This article reviews the integrative physiology and pathophysiology of cardio-renal impairment, critical new insights derived from CPET technology, and contemporary evidence for potential applications of CPET technology in patients with kidney disease.

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What Happens to the Heart in Chronic Kidney Disease?

Cited by 22 publications

References 60 publications

Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease

Polymorphisms in the 5’-UTR region of IL-10RA gene are associated with chronic kidney disease

Coronary Artery Bypass Graft in a Young Man

Cardiovascular Functional Changes in Chronic Kidney Disease: Integrative Physiology, Pathophysiology and Applications of Cardiopulmonary Exercise Testing

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