What happens to brain outside the thermal ablation zones? An assessment of needle-based therapeutic ultrasound in survival swine

Szewczyk, Benjamin; Tarasek, Matthew; Campwala, Zahabiya; Trowbridge, Rachel; Zhao, Zhanyue; Johansen, Phillip; Olmsted, Zachary T.; Bhushan, Chitresh; Fiveland, Eric; Ghoshal, Goutam; Heffter, Tamas; Tavakkolmoghaddam, Farid; Bales, Charles; Wang, Yan; Rajamani, Dhruv Kool; Gandomi, Katie Y.; Nycz, Christopher J.; Jeannotte, Erin; Mane, Shweta; Nalwalk, Julia W.; Burdette, Everette C.; Fischer, Gregory S.; Jiang, Qian; Pilitsis, Julie G.

doi:10.1080/02656736.2022.2126901

Cited by 1 publication

(1 citation statement)

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“…In contrast, HIFU uses FUS beams to thermally ablate or mechanically destroy target tissues [ 119 ]. Advancing technologies and new modalities of administering ultrasonic energy, such as needle-based therapeutic ultrasound, have improved the ability of HIFU to work through the calvarium [ 120 ]. Notwithstanding, much of the existing clinical literature surrounding HIFU for brain tumors surrounds centrally located brain tumors.…”

Section: Tumor Subtypesmentioning

confidence: 99%

Focused ultrasound for treatment of peripheral brain tumors

et al. 2023

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Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). Magnetic resonance guided focused ultrasound (MRgFUS) is a new and promising intervention for CNS tumors, which has shown success in preclinical trials. High-intensity focused ultrasound (HIFU) has the capacity to serve as a direct therapeutic agent in the form of thermoablation and mechanical destruction of the tumor. Low-intensity focused ultrasound (LIFU) has been shown to disrupt the BBB and enhance the uptake of therapeutic agents in the brain and CNS. The authors present a review of MRgFUS in the treatment of CNS tumors. This treatment method has shown promising results in preclinical trials including minimal adverse effects, increased infiltration of the therapeutic agents into the CNS, decreased tumor progression, and improved survival rates.

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Section: Tumor Subtypesmentioning

confidence: 99%