What does the population know about risk and protective factors for dementia? An international review of the current state of knowledge in various countries

Zülke, Andrea; Luppa, Melanie; Köhler, Sebastian; Riedel‐Heller, Steffi G.

doi:10.1007/s00115-023-01471-x

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Cerebrovascular diseases, including chronic cerebral hypoperfusion (CCH), are considered to be high risk factors for cognitive decline in vascular dementia (VaD) [ 18 ]. Meanwhile, underlying diseases such as hypertension and diabetes mellitus have been repeatedly mentioned as risk factors for dementia in the studies by Zülke et al [ 19 , 20 ]. Even chronic digestive diseases such as inflammatory bowel disease (IBD) and Crohn’s disease (CD) have emerged as new risk factors for dementia [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study

Ma,

Feng,

Chen

et al. 2024

Neurol Ther

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Introduction Recent studies have suggested a potential association between methotrexate use and an increased risk of dementia. However, the causal relationship between methotrexate and dementia remains unclear. This study aims to investigate the potential causal effect of methotrexate use on the risk of dementia using a two-sample Mendelian randomization (TSMR) approach. Methods We conducted a TSMR study using summary statistics from genome-wide association studies (GWAS) of methotrexate use and dementia. We obtained genetic instruments for methotrexate use from a large-scale GWAS meta-analysis and genetic instruments for dementia from a separate GWAS meta-analysis. We performed several statistical analyses, including inverse-variance weighted (IVW), weighted median (WM1), weighted mode (WM2), and MR-Egger regression methods, to estimate the causal effect of methotrexate on dementia risk. Results Our TSMR analysis showed a significant positive association between genetic predisposition to methotrexate use and dementia risk. The IVW method estimated a causal odds ratio (OR) of 0.476 [95% confidence interval (CI) 0.362–0.626] per unit increase in the log odds ratio of methotrexate use. WM1, WM2, and MR-Egger methods provided consistent results. Conclusion The findings of this mendelian randomization (MR) study suggest a potential causal effect of methotrexate use on the risk of dementia. However, further research is needed to validate these findings and explore the underlying mechanisms. Since methotrexate is widely prescribed for various autoimmune diseases, a better understanding of its potential impact on dementia risk is crucial for optimizing treatment strategies and addressing potential adverse effects.

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Section: Introductionmentioning

confidence: 99%

Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study

Ma,

Feng,

Chen

et al. 2024

Neurol Ther

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Digital information materials on dementia—an exploratory content analysis

Daube,

Reifegerste

2024

Bundesgesundheitsbl

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Zusammenfassung Hintergrund Eine Demenzdiagnose bedeutet eine hohe Belastung für die Betroffenen und ihre Angehörigen. Häufig müssen schwierige Entscheidungen getroffen werden. Idealerweise treffen Menschen mit einer neuen Demenzdiagnose informierte Entscheidungen gemeinsam mit Angehörigen. Im Vorfeld einer informierten Entscheidung sind digitale Informationsmaterialien eine wichtige niederschwellige Quelle. Sie sollten möglichst umfassend über Demenz aufklären, sowohl zur Primärprävention (Risikofaktoren für Demenzentstehung) als auch zu späteren Behandlungsmöglichkeiten. Auch über vorsorgliche Maßnahmen, die spätere Entscheidungen erleichtern können (bspw. Patient*innenverfügung, Vorsorgevollmacht), sollte informiert werden. Einen umfassenden Überblick über die diversen Onlineangebote zu Demenzerkrankungen gibt es bisher nicht. Methode Daher untersucht diese Studie im deutschen Sprachraum mittels einer innovativen systematischen Suchstrategie, welche demenzbezogenen Informationsangebote es digital für welche Zielgruppen gibt und wie diese Materialien inhaltlich hinsichtlich Risikofaktoren und Behandlungsmaßnahmen sowie Entscheidungsunterstützungen aufbereitet sind. Dieser methodische Ansatz ist neu und wird daher ausführlich vorgestellt und diskutiert. Ergebnisse Die Ergebnisse zeigen, dass die meisten Materialien für Menschen mit Demenz sowie deren Angehörige aufbereitet sind. Häufig werden Behandlungsmaßnahmen thematisiert, ohne die Risikofaktoren zu erklären, auf die diese Maßnahmen abzielen. Auf präventive Maßnahmen zur Entscheidungsunterstützung wird kaum eingegangen. Diskussion Die unausgewogene Darstellung kann dazu führen, dass einzelne Maßnahmen (für Laien) schwer nachvollziehbar sind oder Risikofaktoren falsch eingeordnet werden. Wichtige Implikationen werden abgeleitet.

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Older adults’ awareness of modifiable risk and protective factors for dementia and interest in eHealth interventions for brain health: a comparison between the Netherlands and Germany

Zülke,

Luppa,

van Boxtel

et al. 2023

BMC Public Health

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Background Evidence on modifiable risk factors for dementia is accumulating rapidly, including e.g. smoking, hypertension, and diabetes. Comparing knowledge of risk factors for dementia and factors associated with knowledge and motivation to learn about dementia risk reduction in different countries may support the design of tailored public health campaigns. We investigated (1) differences in knowledge of risk and protective factors for dementia between the Netherlands and Germany, and interest in (2) information on brain health and (3) eHealth for brain health. Materials and methods Population-based telephone (Germany) or web-based surveys (Netherlands) were conducted among adults aged 60–75 (ntotal=614; Germany: n = 270; Netherlands: n = 344), assessing sociodemographic factors, knowledge of risk and protective factors for dementia, interest in information on brain health and respective eHealth-tools. Correlates of knowledge, interest in information on brain health and eHealth for brain health were analyzed using multivariable regression, by country and in pooled analyses. Results In the total sample (Mage: 67.3 (SD: 4.3) years; %female: 48.6), knowledge of risk and protective factors (sum score assessing number of correctly identified factors) was higher among German participants (M (SD) = 7.6 (2.5) vs. 6.0 (4.3), p < .001). This was confirmed using linear regression analyses, controlling for sociodemographic covariates (b = 1.51; 95% CI: 1.00; 2.01). High education was linked to better knowledge of risk and protective factors (b = 1.61; 95% CI: 0.89; 2.34). Controlling for covariates, interest in information on brain health (OR: 0.05, 95% CI: 0.02; 0.09) and eHealth for brain health (OR: 0.40, 95% CI: 0.25; 0.65) was lower in German participants. Widowed participants were less interested in information on brain health, while widowed and single participants expressed less interest in eHealth for brain health in pooled analyses. Further associations between sociodemographic factors, interest in information on brain health and eHealth for brain health by country were detected. Discussion Engaging older adults in the design of eHealth interventions and cooperation with trusted sources, e.g., general practitioners, might enhance appreciation of eHealth for brain health. Education on risk and protective factors for dementia is warranted in both countries. However, differences in recruitment and assessment need to be acknowledged.

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What does the population know about risk and protective factors for dementia? An international review of the current state of knowledge in various countries

Cited by 3 publications

References 32 publications

Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study

Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study

Digital information materials on dementia—an exploratory content analysis

Older adults’ awareness of modifiable risk and protective factors for dementia and interest in eHealth interventions for brain health: a comparison between the Netherlands and Germany

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