Methotrexate and the Risk of Dementia: A Two-Sample Mendelian Randomization Study
Xiao-Na Ma,
Wei Feng,
Shu-Lin Chen
et al.
Abstract:Introduction
Recent studies have suggested a potential association between methotrexate use and an increased risk of dementia. However, the causal relationship between methotrexate and dementia remains unclear. This study aims to investigate the potential causal effect of methotrexate use on the risk of dementia using a two-sample Mendelian randomization (TSMR) approach.
Methods
We conducted a TSMR study using summary statistics from genome-wide association studies (GWA… Show more
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