What can one chromosome tell us about human biogeographical ancestry?

Toma, Tanjin Taher; Williams, Zachary D.; Dawson, Jeremy; Adjeroh, Donald A.

doi:10.1109/bibm.2017.8217648

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Since SNPs are stable over generations, they are excellent genetic markers. It is important to explore the role of SNPs in the genetic analysis of diseases, as they would enable the identification of complex diseases and genetic disorders [12]. Even though SNPs have been shown to be an important factor in genetic variation [13,14], detecting SNPs is still expensive and time-consuming with existing techniques.…”

Section: Introductionmentioning

confidence: 99%

Nucleotide Identification in DNA Using Dielectrophoresis Spectroscopy

et al. 2019

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We show that negative dielectrophoresis (DEP) spectroscopy is an effective transduction mechanism of a biosensor for the detection of single nucleotide polymorphism (SNP) in a short DNA strand. We observed a frequency dependence of the negative DEP force applied by interdigitated electrodes to polystyrene microspheres (PM) with respect to changes in both the last and the second-to-last nucleotides of a single-strand DNA bound to the PM. The drift velocity of PM functionalized to single-strand DNA, which is proportional to the DEP force, was measured at the frequency range from 0.5 MHz to 2 MHz. The drift velocity was calculated using a custom-made automated software using real time image processing technique. This technology for SNP genotyping has the potential to be used in the diagnosis and the identification of genetic variants associated with diseases.

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Section: Introductionmentioning

confidence: 99%