This work provides a unified framework for addressing the problem of visual supervised domain adaptation and generalization with deep models. The main idea is to exploit the Siamese architecture to learn an embedding subspace that is discriminative, and where mapped visual domains are semantically aligned and yet maximally separated. The supervised setting becomes attractive especially when only few target data samples need to be labeled. In this scenario, alignment and separation of semantic probability distributions is difficult because of the lack of data. We found that by reverting to point-wise surrogates of distribution distances and similarities provides an effective solution. In addition, the approach has a high "speed" of adaptation, which requires an extremely low number of labeled target training samples, even one per category can be effective. The approach is extended to domain generalization. For both applications the experiments show very promising results.

In the Internet age, malware (such as viruses, trojans, ransomware, and bots) has posed serious and evolving security threats to Internet users. To protect legitimate users from these threats, anti-malware software products from different companies, including Comodo, Kaspersky, Kingsoft, and Symantec, provide the major defense against malware. Unfortunately, driven by the economic benefits, the number of new malware samples has explosively increased: anti-malware vendors are now confronted with millions of potential malware samples per year. In order to keep on combating the increase in malware samples, there is an urgent need to develop intelligent methods for effective and efficient malware detection from the real and large daily sample collection. In this article, we first provide a brief overview on malware as well as the anti-malware industry, and present the industrial needs on malware detection. We then survey intelligent malware detection methods. In these methods, the process of detection is usually divided into two stages: feature extraction and classification/clustering . The performance of such intelligent malware detection approaches critically depend on the extracted features and the methods for classification/clustering. We provide a comprehensive investigation on both the feature extraction and the classification/clustering techniques. We also discuss the additional issues and the challenges of malware detection using data mining techniques and finally forecast the trends of malware development.

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RNA-protein complexes are essential in mediating important fundamental cellular processes, such as transport and localization. In particular, ncRNA-protein interactions play an important role in post-transcriptional gene regulation like mRNA localization, mRNA stabilization, poly-adenylation, splicing and translation. The experimental methods to solve RNA-protein interaction prediction problem remain expensive and time-consuming. Here, we present the RPI-Pred (RNA-protein interaction predictor), a new support-vector machine-based method, to predict protein-RNA interaction pairs, based on both the sequences and structures. The results show that RPI-Pred can correctly predict RNA-protein interaction pairs with ∼94% prediction accuracy when using sequence and experimentally determined protein and RNA structures, and with ∼83% when using sequences and predicted protein and RNA structures. Further, our proposed method RPI-Pred was superior to other existing ones by predicting more experimentally validated ncRNA-protein interaction pairs from different organisms. Motivated by the improved performance of RPI-Pred, we further applied our method for reliable construction of ncRNA-protein interaction networks. The RPI-Pred is publicly available at: http://ctsb.is.wfubmc.edu/projects/rpi-pred.