What Can Epidemiology Tell Us About the Role of Infant Diet in the Etiology of IDDM?

Kostraba, Jill N

doi:10.2337/diacare.17.1.87

Cited by 25 publications

(15 citation statements)

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“…The results of previous case-control (3) and epidemiologic (8) studies suggest that dietary exposure in early life is associated with risk of type 1 diabetes. It is plausible that amount and quality of energy intake in particular periods of life can influence the processes of ␤ cell injury (22) and defense (23).…”

Section: Discussionmentioning

confidence: 80%

“…In a Swedish case-control study, meat protein rather than fat was a risk factor for diabetes (3). A link between average per capita milk consumption and type 1 diabetes seems to be based on the induction of ␤ cell autoimmunity through molecular mimicry of bovine serum albumin with ICA69 antigen (8).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, an ecologic analysis showed a positive correlation between nitrate concentrations in drinking water and type 1 diabetes risk (7). However, no clear evidence of a relation between the disease and solid food items has emerged from experimental animal or human studies (3,8). We conducted an ecologic study of average daily amount and type of energy intake in relation to incidence of childhood type 1 diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Nutritional factors and worldwide incidence of childhood type 1 diabetes

Muntoni

Cocco

Aru

et al. 2000

The American Journal of Clinical Nutrition

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Background: Some dietary factors have been associated with the risk of type 1 diabetes in childhood. Objective: We investigated relations between dietary energy from major food groups and incidence of childhood type 1 diabetes by using an ecologic study design. Design: We conducted univariate and multivariate regression analysis with incidence rates of type 1 diabetes in the late 1980s and early 1990s among children aged < 15 y in 40 countries as the dependent variable and average per capita daily intake of major food items and other socioeconomic, demographic, and geographic risk factors as the independent variables. Results: In the univariate regression model, per capita total energy intake was nonsignificantly associated with type 1 diabetes incidence (r = 0.31, NS), whereas energy from animal sources was associated (r = 0.61, P < 0.01) and energy from vegetal sources was inversely associated (r = Ϫ0.35, P < 0.05) with diabetes incidence. Among dietary items of animal origin, meat (r = 0.55, P < 0.001) and dairy products (r = 0.80, P < 0.0001) were predictors of elevated incidence rates, whereas among dietary items of vegetal origin, cereals (r = Ϫ0.64, P < 0.001) were inverse predictors. In the multivariate analysis, the inverse relation of diabetes incidence with energy from vegetables and the direct correlation with energy from animal sources explained the positive associations of type 1 diabetes incidence with geographic and socioeconomic covariates. Conclusion: The incidence of type 1 diabetes varied worldwide according to dietary patterns. In-depth exploration of dietary risk factors during pregnancy and early neonatal life is warranted to confirm whether and to what extent diet cooperates with genetic susceptibility in the early onset of type 1 diabetes.Am J Clin Nutr 2000;71:1525-9.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nutritional factors and worldwide incidence of childhood type 1 diabetes

Muntoni

Cocco

Aru

et al. 2000

The American Journal of Clinical Nutrition

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“…It allows other factors, which in patients with genetic predisposition to DM1 development might activate autoimmune response against pancreatic ␤ cells to have better access to lamina propria of the intestinal mucosa (16).…”

Section: Discussionmentioning

confidence: 99%

Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

et al. 2008

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“…On the other hand, environmental factors have also been suggested to contribute to this difference (5). The prevalence of type 1 diabetes is increased among individuals who were not breast-fed or who received mothers milk only for a short period of time (6). Recently, Gimeno and Souza (7) showed that shorter duration of exclusive breastfeeding was a risk factor for type 1 diabetes and that the introduction to cows milk before the age of 8 days was also a risk factor for the disease (7).…”

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confidence: 99%

Incidence of type 1 diabetes mellitus in Passo Fundo, RS, Brazil

Lisboa

Graebin

Butzke

et al. 1998

Braz J Med Biol Res

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To establish the incidence of type 1 diabetes among children (infants to 14 years of age) in the city of Passo Fundo, Rio Grande do Sul, Brazil (population under 15 years = 50,098), during the period of January to December 1996, a retrospective and prospective population-based registry was established, using physician reports of newly diagnosed patients under 15 years of age with type 1 diabetes as the primary source of case identification. Primary and nursery schools and a general call through the media (newspapers, radio and television) was the secondary source. Data were calculated according to the methods recommended by the WHO (1990). Six new cases were identified. Case ascertainment was estimated at 100%. The incidence of type 1 diabetes in the year 1996 was 12/100,000 inhabitants. These data indicate that the incidence of childhood type 1 diabetes in a subtropical region in the Southern part of Brazil was similar to that observed in developed countries throughout the world. The inability to demonstrate the North-South gradient is probably due to the European origin of inhabitants of the city.

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What Can Epidemiology Tell Us About the Role of Infant Diet in the Etiology of IDDM?

Cited by 25 publications

References 0 publications

Nutritional factors and worldwide incidence of childhood type 1 diabetes

Nutritional factors and worldwide incidence of childhood type 1 diabetes

Immunologic and Biochemical Factors of Coincident Celiac Disease and Type 1 Diabetes Mellitus in Children

Incidence of type 1 diabetes mellitus in Passo Fundo, RS, Brazil

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