What are the PANSS items most related with global improvements in patients with schizophrenia? Toward a reduced version of the PANSS

Relationship Between Symptomatic Improvement and Overall Illness Severity in Patients With Schizophrenia

“…[7][8][9][10][11][12][13][14] Comparatively less is known about the impact of symptomatic improvement in specific domains and their relationship with changes in overall illness severity ratings. 16 Both of these investigations were restricted to an acutely ill inpatient sample and had relatively short follow-up, limiting generalizability of the findings. 15 Change in positive symptoms was the strongest predictor of change in overall illness severity, with relatively smaller yet independent contributions made by change in negative and agitation symptoms.…”

Can the Positive and Negative Syndrome scale (PANSS) differentiate treatment-resistant from non-treatment-resistant schizophrenia? A factor analytic investigation based on data from the Pattern cohort study

“…In fact there were many attempts to reduce the PANSS in order to obtain clusters of items which could represent valid and reliable factors to better measure severity of illness (Ortiz et al, 2014) or predict treatment response, (Ortiz et al, 2014). Of note is the fact Item Response Theory , and not FA, has been proposed as the method of choice for such endeavor {Levine, 2011 #454 and a recent study based on this method which used the PANSS-6 (Ostergaard et al, 2018) (composed by delusions, conceptual disorganization, hallucinatory behavior, blunted affect, passive/ apathetic social withdrawal and lack of spontaneity) proved to be a valid and sensible instrument for the evaluation of severity , remission and efficacy in patients with TRS of phase 2E of the CATIE study (McEvoy et al, 2006).…”