Can the Positive and Negative Syndrome scale (PANSS) differentiate treatment-resistant from non-treatment-resistant schizophrenia? A factor analytic investigation based on data from the Pattern cohort study

Freitas, Rosana; Santos, Bernardo dos; Altamura, Carlo; Bernasconi, Corrado; Corral, Ricardo; Evans, Jonathan; Malla, Ashok; Krebs, M.O.; Nordstroem, Anna Lena; Zink, Mathias; Haro, Josep María; Elkis, Hélio

doi:10.1016/j.psychres.2019.05.002

Cited by 12 publications

(3 citation statements)

References 51 publications

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“…Explanatory models of TR using longitudinal data have identified younger age of onset ( Chan et al, 2021 ; Wimberley et al, 2016 ), being male ( Szymanski et al, 1995 ), and never marrying ( Emsley et al, 2006 ) as factors associated with TR. Previous studies comparing TR and NTR patients have failed to find a difference in the number of years in education ( Frydecka et al, 2016 ; Iasevoli et al, 2018c ), alcohol use ( Chen et al, 2018 ), and positive symptoms ( Freitas et al, 2019 ; Iasevoli et al, 2018a ), although one study of treatment non-responders vs responders found a difference in BMI ( Chiliza et al, 2015 ). It is important to note, however, that our model coefficients can be only interpreted in the context of their contribution to the prediction of TR.…”

Section: Discussionmentioning

confidence: 99%

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Smart

Agbedjro

Pardiñas

et al. 2022

Schizophrenia Research

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Section: Discussionmentioning

confidence: 99%

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Smart

Agbedjro

Pardiñas

et al. 2022

Schizophrenia Research

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“…The Positive and Negative Syndromes Scale (PANSS) is the most widely used symptom assessment scale in research and clinical trials for schizophrenia ( 23 , 24 ). It consists of 30 items, and can provide a broad assessment of positive (7 items), negative (7 items), and general symptoms (16 items) ( 25 ).…”

Section: Methodsmentioning

confidence: 99%

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

Liu¹,

Zhang²,

Huo³

et al. 2022

Front. Psychiatry

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AimsThe purpose of this study was to investigate the prevalence, influencing factors, and clinical characteristics of cognitive impairment in elderly patients with chronic schizophrenia.Materials and MethodsA total of 264 elderly patients with chronic schizophrenia and 156 normal controls were enrolled in the current study. The Mini-mental State Examination (MMSE) was used to assess their overall cognitive function, the Positive And Negative Syndrome Scale (PANSS) was used to assess their psychotic symptoms, the Geriatric Depression Scale (GDS) was used to assess their depressive symptoms, while Activity of Daily Living Scale (ADL) was used to assess their daily living ability.ResultsThe prevalence of cognitive impairment was 77.7% (205/264) in elderly patients with chronic schizophrenia, which was much higher than that [16.7% (26/156)] in normal controls. By using stepwise binary regression analysis, we found that hobbies (p < 0.001, OR = 0.224, 95% CI: 0.114–0.441) might be a protective factor for cognitive impairment, and this relationship remained statistically significant after adjusting for total scores of GDS, ADL and PANSS (modelb) (p = 0.016, OR = 0.406, 95% CI: 0.195–0.847). Compared with individuals without cognitive impairment, individuals with cognitive impairment tend to have more depression and psychiatric symptoms as well as worse activities of daily living (p < 0.05). Through linear regression analysis of the mediating model, we found that hobbies may improve cognitive function by improving psychiatric symptoms, and play a partial mediating role (B = −4.789, p < 0.001).ConclusionCognitive impairment is a very prominent problem in elderly patients with chronic schizophrenia. Elderly schizophrenia patients with cognitive impairment tended to have more depressive mood, more psychotic symptoms and worse activities of daily living. Hobbies will help prevent cognitive impairment in elderly patients with schizophrenia and may improve their cognitive function by influencing psychiatric symptoms. Therefore, we should encourage elderly patients with chronic schizophrenia to develop their own hobbies. However, the above conclusion still need to be further verified, as we cannot exclude the effects of age and education.

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“… 32 The PANSS has been widely used in the assessment of psychiatric symptoms in schizophrenia and other psychiatric disorders. 33 , 34 …”

Section: Methodsmentioning

confidence: 99%

Prevalence, Influencing Factors, and Cognitive Characteristics of Depressive Symptoms in Elderly Patients with Schizophrenia

Chen¹,

Li²

2021

NDT

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Purpose To investigate the prevalence, influencing factors, and cognitive characteristics of depressive symptoms in elderly patients with chronic schizophrenia. Patients and Methods A total of 241 elderly patients with chronic schizophrenia and 156 healthy controls were enrolled in this study. The Geriatric Depression Scale (GDS) was used to assess depressive symptoms; the Positive and Negative Syndrome Scale was used to assess psychotic symptoms; and both the Mini-Mental State Examination and Montreal Cognitive Assessment were used to assess overall cognitive function, while the Activity of Daily Living Scale was used to assess daily living ability. Results The prevalence of depressive symptoms was 48.5% (117/241) in elderly patients with chronic schizophrenia, which was substantially higher than that of normal controls (17.3%, 27/156). Using a stepwise binary logistic regression analysis, we found that high education (p=0.006, odds ratio [OR]=1.122, 95% confidence interval [CI]:1.034–1.218) and hypertension (p=0.019, OR=0.519, 95% CI: 0.300–0.898) were influencing factors for the comorbidity of depressive symptoms. Compared with individuals without depressive symptoms, individuals with depressive symptoms usually display worse overall cognitive function and more severe impairment of activities of daily living, but fewer psychotic symptoms. Interestingly, the GDS score was negatively correlated with the course of the disease (r=−0.157, p=0.016), suggesting that patients who had recently been admitted to the hospital were more likely to develop depression. Conclusion Elderly patients with chronic schizophrenia are often associated with higher levels of depression. Therefore, their overall cognitive function is worse, and their activities of daily living are more seriously impaired. Therefore, these patients should be provided with appropriate psychological comfort, especially those who have recently been admitted to the hospital.

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Can the Positive and Negative Syndrome scale (PANSS) differentiate treatment-resistant from non-treatment-resistant schizophrenia? A factor analytic investigation based on data from the Pattern cohort study

Cited by 12 publications

References 51 publications

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

Prevalence, Influencing Factors, and Cognitive Characteristics of Depressive Symptoms in Elderly Patients with Schizophrenia

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