Prevalence, Influencing Factors, and Cognitive Characteristics of Depressive Symptoms in Elderly Patients with Schizophrenia

Chen, Yaopian; Li, Wei

doi:10.2147/ndt.s341297

Cited by 3 publications

(2 citation statements)

References 57 publications

(53 reference statements)

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“…It is able to assess a range of areas, ranging from emotion (e.g., crying, apathy, sadness) to cognition (e.g., helplessness, guilt, worthlessness) ( 29 ). Previous studies have demonstrated that GDS can effectively assess emotional symptoms in elderly patients with chronic schizophrenia ( 30 ).…”

Section: Methodsmentioning

confidence: 99%

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

Liu¹,

Zhang²,

Huo³

et al. 2022

Front. Psychiatry

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AimsThe purpose of this study was to investigate the prevalence, influencing factors, and clinical characteristics of cognitive impairment in elderly patients with chronic schizophrenia.Materials and MethodsA total of 264 elderly patients with chronic schizophrenia and 156 normal controls were enrolled in the current study. The Mini-mental State Examination (MMSE) was used to assess their overall cognitive function, the Positive And Negative Syndrome Scale (PANSS) was used to assess their psychotic symptoms, the Geriatric Depression Scale (GDS) was used to assess their depressive symptoms, while Activity of Daily Living Scale (ADL) was used to assess their daily living ability.ResultsThe prevalence of cognitive impairment was 77.7% (205/264) in elderly patients with chronic schizophrenia, which was much higher than that [16.7% (26/156)] in normal controls. By using stepwise binary regression analysis, we found that hobbies (p < 0.001, OR = 0.224, 95% CI: 0.114–0.441) might be a protective factor for cognitive impairment, and this relationship remained statistically significant after adjusting for total scores of GDS, ADL and PANSS (modelb) (p = 0.016, OR = 0.406, 95% CI: 0.195–0.847). Compared with individuals without cognitive impairment, individuals with cognitive impairment tend to have more depression and psychiatric symptoms as well as worse activities of daily living (p < 0.05). Through linear regression analysis of the mediating model, we found that hobbies may improve cognitive function by improving psychiatric symptoms, and play a partial mediating role (B = −4.789, p < 0.001).ConclusionCognitive impairment is a very prominent problem in elderly patients with chronic schizophrenia. Elderly schizophrenia patients with cognitive impairment tended to have more depressive mood, more psychotic symptoms and worse activities of daily living. Hobbies will help prevent cognitive impairment in elderly patients with schizophrenia and may improve their cognitive function by influencing psychiatric symptoms. Therefore, we should encourage elderly patients with chronic schizophrenia to develop their own hobbies. However, the above conclusion still need to be further verified, as we cannot exclude the effects of age and education.

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Section: Methodsmentioning

confidence: 99%

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

Liu¹,

Zhang²,

Huo³

et al. 2022

Front. Psychiatry

Self Cite

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“…It was estimated that approximately 48.5% of elderly patients with schizophrenia experienced depressive symptoms and displayed poor cognitive function and severe impairment of activities of daily living. [ 7 ] Depression can significantly impair the individual’s physical function. [ 8 ] Furthermore, the concurrence of schizophrenia, bipolar disorder, and depression was thought to be associated with suicidal behaviors.…”

Section: Introductionmentioning

confidence: 99%

The mediating effects of social support on the association between depression and life satisfaction among patients with schizophrenia or bipolar disorder

Zhang

Shi²,

Rao

et al. 2023

Medicine

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Patients with schizophrenia or bipolar disorders in community had poor psychosocial functioning, social support, and life satisfaction. However, the interaction effects of social support and depression on life satisfaction remains unclear. Thus, we examined these associations among patients with schizophrenia or bipolar disorder. This cross-sectional study was conducted from October to December 2020 in Shenzhen, China. Information on social support, depression, and life satisfaction was assessed by standardized questionnaires through a face-to-face interview. Hierarchical multiple regression analysis was performed to estimate the associations of social support and depression with life satisfaction and to explore the mediation effect of social support. A total of 293 patients aged 39.7 ± 11.1 years (males: 47.1 %) were included in this study. Social support was positively associated with high life satisfaction (explaining 7.2% of the variance), while depression was negatively associated with life satisfaction (explaining 17.8% of the variance). Furthermore, social support mediated 12.5% of the association between depression and life satisfaction. Social support and depression were significantly associated with life satisfaction in patients with schizophrenia or bipolar disorders. Moreover, social support mediated the association between depression and life satisfaction in this population. Health interventions that benefit social support should be promoted to alleviate the negative impact of depression on their life satisfaction.

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Physical activity levels associated with insomnia and depressive symptoms in middle-aged and elderly patients with chronic schizophrenia

Liu¹,

Sun²,

Wang³

et al. 2023

Front. Psychiatry

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BackgroundPrevious evidence suggested that physical activity had beneficial effects on psychopathological symptoms, insomnia, or depressive symptoms in people with schizophrenia. This study investigated the association between physical activity levels and insomnia and depressive symptoms in middle-aged and elderly hospitalized patients with chronic schizophrenia (CS).Methods179 participants were enrolled. We used the 30-item Positive and Negative Syndrome Scale (PANSS–30) to assess the psychopathological symptoms. We used the Insomnia Severity Index scale (ISI) and 17-item Hamilton Depression Scale (HAMD-17) to evaluate insomnia and depressive symptoms. Daily physical activity time less than 30 min, within 30–60 min, and more than 60 min were defined as physical inactivity, moderate physical activity, and vigorous physical activity, respectively. The Chi-square test, analysis of variance (ANOVA), and Mann–Whitney U-test were applied for categorical, continuous, and non-normal distribution variables, respectively. The Pearson or Spearman’s correlation analyses were utilized to examine the association between physical activity levels, ISI total scores, HAMD total scores, and socio-demographic and clinical variables. Finally, socio-demographic variables with a P-value < 0.05 in the comparison between insomnia/depressive group and non-insomnia/depressive group were considered for inclusion in binary logistic regression analysis to determine the relationship between physical activity levels and insomnia or depressive symptoms.ResultsThe ISI total scores (r = –0.247, P = 0.001) and HAMD total scores (r = –0.312, P < 0.001) were negatively correlated with physical activity levels. Logistic regression analysis revealed that older age, higher depressive factor scores, and lower physical activity level were influential factors of insomnia symptoms in CS patients (P < 0.05). In addition, vigorous physical activity (compared with physical inactivity) and higher negative and depressive factor scores were independently associated with depressive symptoms in CS patients (P < 0.05).ConclusionPhysical activity levels were influential factors in comorbid insomnia and depressive symptoms in CS patients. Given the benefits of physical activity, it should be strengthened as a routine adjunct to clinical treatment or psychiatric care so as to improve the physical and mental health of patients with psychiatric symptoms.

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Prevalence, Influencing Factors, and Cognitive Characteristics of Depressive Symptoms in Elderly Patients with Schizophrenia

Cited by 3 publications

References 57 publications

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia

The mediating effects of social support on the association between depression and life satisfaction among patients with schizophrenia or bipolar disorder

Physical activity levels associated with insomnia and depressive symptoms in middle-aged and elderly patients with chronic schizophrenia

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