What are the dangers of drug interactions with herbal medicines?

Gouws, Chrisna; Hamman, Josias H.

doi:10.1080/17425255.2020.1733969

Cited by 30 publications

(22 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A pharmacokinetic interaction is described as enhanced or reduced absorption, distribution, metabolism and excretion of the drug that occurs when two substances are combined [ 63 ]. A pharmacodynamic interaction refers to the alteration of a drug’s pharmacological effect and mechanism of action caused by the combination of two or more substances [ 27 ]. The clinical consequences of pharmacokinetic and pharmacodynamic interactions vary depending upon whether the effects of the drug are reduced or increased [ 64 ].…”

Section: Potential Interactions Between Commonly Used Medicines For C...mentioning

confidence: 99%

“…Due to the ‘light touch’ regulatory frameworks in many countries, including the USA and Australia, access to DS products does not require consultation or interaction with a healthcare professional, and these products can be easily accessed through pharmacy, retail and online outlets [ 25 , 26 ]. Concerns about potential drug-nutrient and drug-herb interactions have been reported [ 27 ]. Therefore, initiatives that encourage disclosure about prescribed medicine and DS use to healthcare professionals are needed to prevent adverse interactions from occurring [ 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Use of Medications and Dietary Supplements by Masters Athletes — a Review

Harnett

Climstein

Walsh³

et al. 2022

Curr Nutr Rep

View full text Add to dashboard Cite

Purpose of Review Masters athletes (MA) are generally considered healthier than their sedentary peers. However, the prevalence of chronic conditions in any population increases with age. Treatments involve pharmacological and non-pharmacological interventions. A substantial proportion of the general population also use dietary supplements (DS). This raises questions about the potential for drug-nutrient interactions which may lead to adverse effects. We sought to determine the potential for drug-nutrient interactions MA may be exposed to by examining the prevalence of chronic conditions treated with medications and their DS use. Recent Findings Common conditions in MA include hypertension, hyperlipidemia, asthma, osteoarthritis, depression and anxiety. Treatments may involve prescribed medications. Few recent studies were identified on DS use; however, indications are for around 60% prevalence of supplement usage. Summary The higher prevalence of DS use by MA may result in drug-nutrient interactions that impact the effectiveness and safety of prescribed medications for chronic conditions.

show abstract

Section: Potential Interactions Between Commonly Used Medicines For C...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Use of Medications and Dietary Supplements by Masters Athletes — a Review

Harnett

Climstein

Walsh³

et al. 2022

Curr Nutr Rep

View full text Add to dashboard Cite

show abstract

“…In addition, several surveys note that both patients and healthy individuals willingly consume BDS along with conventional medicines, frequently without informing their physician [15]. Such actions may increase the risk for HDIs [16,17]. At present, the BDS recognized as having the greatest HDI risk is Hypericum perforatum (St. Johnʼs wort), a popular botanical marketed for mild to moderate depression that renders many medications ineffective due to its ability to upregulate CYP3A4 expression via PXR activation [18].…”

Section: Discussionmentioning

confidence: 99%

Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp

et al. 2021

View full text Add to dashboard Cite

Bulbine natalensis, an emerging medicinal herb on the global market with androgenic properties, is often formulated in dietary supplements that promote perceived sexual enhancement. However, to date, comprehensive safety studies of B. natalensis are lacking, particularly those related to its herb-drug interaction potential. The purpose of this study was to assess the inductive and inhibitory effects of extracts and pure compounds of B. natalensis on human cytochrome P-450 isozymes in vitro. Our findings demonstrated that both water and methanolic extracts of B. natalensis as well as knipholone, bulbine-knipholone, and 6′-O-methylknipholone dose-dependently increased mRNA expression encoded by CYP2B6, CYP1A2, and ABCB1 genes. Functional analyses showed that water (60 to 2.20 µg/mL) and methanolic (30 to 3.75 µg/mL) extracts and knipholones (10 to 0.33 µM) increased CYP2B6 and CYP1A2 activity in a dose-dependent manner. Additionally, water extract (60 µg/mL), methanolic extract (30 µg/mL), and knipholone (10 µM) caused activation of the aryl hydrocarbon receptor up to 11.1 ± 0.7, 8.9 ± 0.6, and 7.1 ± 2.0-fold, respectively. Furthermore, inhibition studies revealed that methanolic extract attenuated the activity of metabolically active CYP1A2 (IC50, 22.6 ± 0.4 µg/mL) and CYP2B6 (IC50, 34.2 ± 6.6 µg/mL) proteins, whereas water extracts had no inhibitory effect on either isoform. These findings suggest that chronic consumption of B. natalensis may affect normal homeostasis of select CYPs with subsequent risks for HDIs when concomitantly ingested with conventional medications that are substrates of CYP2B6 and CYP1A2. However, more in-depth translational studies are required to validate our current findings and their clinical relevance.

show abstract

“…Medicinal plants have been widely embraced as an alternative to allopathic medicines in many countries for the treatment of various diseases (Nfozon et al, 2019;Gouws et al, 2020). Functional bioactive compounds of plant origin have been the source of innumerable therapeutic agents in drug discovery (Yuan et al, 2016;Mustafa et al, 2017;Dawurung et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

ACUTE ORAL TOXICITY STUDY OF ROOT METHANOL EXTRACT OF Goniothalamus lanceolatus Miq. AND ITS ISOLATED BIOACTIVE COMPOUND (PARVISTONE D) IN MURINE MODEL

Zohdi

Mukhtar

Kaharudin

et al. 2022

MABJ

View full text Add to dashboard Cite

Goniothalamus lanceolatus Miq. is widely used by the indigenous people of Sarawak, Malaysia as a folk remedy to treat various ailments including skin diseases, cold, and fever. A previous study reported that the root methanol extract, and parvistone D, an active compound of the plant, showed promising in vitro antiplasmodial activity against Plasmodium parasites. However, there is limited data reporting on its toxicological profile. Thus, this study aims to evaluate the potential toxicity of root methanol extract and parvistone D of G. lanceolatus in mice. The acute oral toxicity of the extract and compound was assessed at a single dose of 2000 and 500 mg/kg body weight, respectively. The animals were observed for any mortality, behavioral, motor-neuronal abnormalities, and body weight changes for 14 days. At the end of the experiment, relative organ weights were measured, and gross examination, as well as histopathological analysis, were performed. There was no sign of toxicity, and mortality seen in mice treated with G. lanceolatus root methanol extract, and parvistone D at the administered doses. In addition, no significant differences were observed in the body and relative organ weights between the control and treated groups. Gross and histopathological examinations showed normal appearance of the liver, spleen, kidneys, heart, and lungs as compared to their respective control groups. In conclusion, oral administration of root methanol extract, and parvistone D of G. lanceolatus are safe at the studied dosage levels and cause no acute toxicity in mice.

show abstract

What are the dangers of drug interactions with herbal medicines?

Cited by 30 publications

References 7 publications

The Use of Medications and Dietary Supplements by Masters Athletes — a Review

The Use of Medications and Dietary Supplements by Masters Athletes — a Review

Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp

ACUTE ORAL TOXICITY STUDY OF ROOT METHANOL EXTRACT OF Goniothalamus lanceolatus Miq. AND ITS ISOLATED BIOACTIVE COMPOUND (PARVISTONE D) IN MURINE MODEL

Contact Info

Product

Resources

About