Wharton’s Jelly Mesenchymal Stem Cells on a Novel Aloe Vera-Polycaprolactone (A-PCL) Composite Scaffold in Burns

Jehangir, Susan; Ramesh, Sowmya; Thomas, Meera; Madhuri, Vrisha

doi:10.1007/s40883-021-00241-y

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the local transplantation of MSCs causes the low retention of cells at damaged sites, leading to slow recovery [ 20 ]. As a result, researchers propose the immobilization of MSCs on matrices (i.e., fabricated scaffolds or acellular natural matrices) before transplantation at wound sites [ 18 , 21 , 22 ]. During the regeneration process, differentiation growth factors such as fibroblast growth factor (FGF) and keratinocyte growth factor (KGF) are the most important factors in skin regeneration.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds

Mansour

Hasanzadeh

Abasi

et al. 2023

Genes

View full text Add to dashboard Cite

The treatment of full-thickness skin wounds is a problem in the clinical setting, as they do not heal spontaneously. Extensive pain at the donor site and a lack of skin grafts limit autogenic and allogeneic skin graft availability. We evaluated fetal bovine acellular dermal matrix (FADM) in combination with human Wharton’s jelly mesenchymal stem cells (hWJ-MSCs) to heal full-thickness skin wounds. FADM was prepared from a 6-month-old trauma-aborted fetus. WJ-MSCs were derived from a human umbilical cord and seeded on the FADM. Rat models of full-thickness wounds were created and divided into three groups: control (no treatment), FADM, and FADM-WJMSCs groups. Wound treatment was evaluated microscopically and histologically on days 7, 14, and 21 post-surgery. The prepared FADM was porous and decellularized with a normal range of residual DNA. WJ-MSCs were seeded and proliferated on FADM effectively. The highest wound closure rate was observed in the FADM-WJMSC group on days 7 and 14 post-surgery. Furthermore, this group had fewer inflammatory cells than other groups. Finally, in this study, we observed that, without using the differential cell culture media of fibroblasts, the xenogeneic hWJSCs in combination with FADM could promote an increased rate of full-thickness skin wound closure with less inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds

Mansour

Hasanzadeh

Abasi

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

Bioactive functional scaffolds for stem cells delivery in wound healing and skin regeneration

Hazrati

Davaran

Omidi

2022

Reactive and Functional Polymers

View full text Add to dashboard Cite

Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds

Jenssen

Mohamed-Ahmed

Kankuri

et al. 2022

EBJ

View full text Add to dashboard Cite

Cellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods in preclinical and clinical studies of bone-marrow-, adipose-tissue-, and umbilical-cord-derived MSCs for treating burn wounds. Relevant studies were identified through a literature search in PubMed and Embase and subjected to inclusion and exclusion criteria for eligibility. Additional relevant studies were identified through a manual search of reference lists. A total of sixty-nine studies were included in this review. Of the included studies, only five had clinical data from patients, one was a prospective case–control, three were case reports, and one was a case series. Administration methods used were local injection (41% in preclinical and 40% in clinical studies), cell-seeded scaffolds (35% and 20%), topical application (17% and 60%), and systemic injection (1% and 0%). There was great heterogeneity between the studies regarding experimental models, administration methods, and cell dosages. Local injection was the most common administration method in animal studies, while topical application was used in most clinical reports. The best delivery method of MSCs in burn wounds is yet to be identified. Although the potential of MSC treatment for burn wounds is promising, future research should focus on examining the effect and scalability of such therapy in clinical trials.

show abstract

Wharton’s Jelly Mesenchymal Stem Cells on a Novel Aloe Vera-Polycaprolactone (A-PCL) Composite Scaffold in Burns

Cited by 3 publications

References 15 publications

The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds

The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds

Bioactive functional scaffolds for stem cells delivery in wound healing and skin regeneration

Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds

Contact Info

Product

Resources

About