Wettability of pharmaceutical solids: its measurement and influence on wet granulation

Zhang, D; Flory, J.H; Panmai, Santipharp; Batra, Udit; Kaufman, Michael J.

doi:10.1016/s0927-7757(02)00091-2

Cited by 63 publications

(32 citation statements)

References 17 publications

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“…One important physicochemical property of solid-state pharmaceutical excipients is the surface free energy which governs interfacial interactions. Knowledge of surface energetics of excipients can therefore be of similar importance to that of the APIs in the formulation design of multi-component systems and the prediction of processing performance such as binder-drug adhesion, powder flow, compaction and granulation performances (2)(3)(4)(5). Common methods of characterizing the surface energetics of particulate pharmaceuticals rely on indirect approaches involving the use of characterized or known vapours, liquids or solids as probes as in inverse gas chromatography (IGC) (6), sessile drop contact angle (7) and atomic force microscopy (AFM) (8) respectively.…”

Section: Introductionmentioning

confidence: 99%

Determination of surface heterogeneity of d-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography

Hinder

Watts

et al. 2010

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Determination of surface heterogeneity of d-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography

Hinder

Watts

et al. 2010

International Journal of Pharmaceutics

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“…Strong and dense granules are produced if the spreading co-Ž efficient of the binder on the particles is positive Rowe, 1989; . Zajic and Buckton, 1990;Zhang et al, 2002 . There are two mechanisms of tablet disintegration: swelling Ž . Ž such as for starch or dissolution such as for povidone and .…”

mentioning

confidence: 99%

Product‐centered processing: Pharmaceutical tablets and capsules

Fung

2003

AIChE Journal

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A systematic procedure is presented for synthesizing and de®eloping a manufacturing process for pharmaceutical tablets and capsules. The product quality factors ᎏ functional, physical and sensorial ᎏ are first identified. The dosage form and excipients are then selected, and the process flowsheet is synthesized along with the suitable equipment and operating conditions. Finally, the product and process are e®aluated to ensure that the product possesses the desired quality factors. Design heuristics and physical models are pro®ided to assist decision-making. Examples in®ol®ing Vitamin C, antacid, and ginseng are pro®ided to illustrate the procedure. IntroductionPharmaceuticals with global sales expected to reach $406 billion in 2002 constitute a significant fraction of the chemi-Ž . cal processing industries Bailey, 2000 . They are delivered in different dosage formsᎏsolids, liquids, creams, pastes, and Ž . aerosols. Since active pharmaceutical ingredients API are normally in the solid state, most common are solid dosage Ž . forms, particularly tablets and capsules Zanowiak, 1988a , which are convenient to use and provide precise dosage.There are a wide variety of tablets and capsules. While the majority are designed to be absorbed in the gastrointestinal tract, lozenges are expected to act on the mouth and throat. Most tablets are directly swallowed, but some are supposed to be chewed by children or elderly with swallowing difficulty. Effervescent tablets are dissolved either directly in the mouth or in water before ingestion. Prolonged release tablets and capsules provide an extended therapeutic effect.Despite the economic significance of solid dosage forms, relatively little has been done from the process systems engineering perspective. This is a serious omission because an effective workflow is expected to reduce the time and effort required for launching a product. Indeed, it is generally accepted that product engineering and solids processing de-Ž serves much more attention Tanguy and Marchal, 1996;Villadsen, 1997;Kind, 1999; Wintermantel, 1999;Cussler and . Ž . Moggridge, 2001 . Recently, Wibowo and Ng 2001b consid-Correspondence concerning this article should be addressed to Ka M. Ng. ered the integration of product design and process design for creams and pastes; customer preferences lead to desirable quality factors that are then achieved by properly designing the process. This article presents such a product-centered systematic procedure for the synthesis and development of tablet and capsule manufacturing processes. Systematic Procedure Ž .There are 4 steps: 1 Identification of product quality fac-Ž . Ž . tors, 2 Product formulation, 3 Design of manufacturing Ž . process, and 4 Product and process evaluation. Design heuristics and physical models are presented to assist decision-making in each step.Step 1: identification of product quality factors Product quality factors other than therapeutic effects can be divided into functional, physical, and sensorial. For pharmaceuticals, the primary concern...

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“…They found heterogeneity of ingredients was greater in smaller sized particles. The results with foam binder delivery do not display the anticipated de-mixing with increasingly hydrophobic species, which others (Nguyen et al, 2010;Zhang et al, 2002) have ascribed to preferential granulation of hydrophilic components with a hydrophilic granulating agent. Equally interesting was the fact that the differences in particle size, especially between griseofulvin and acetaminophen, did not shown any influence on the API distribution in the present study; selective growth favoring smaller feed particles will occur under specific processing conditions predicted by Stokes theory whereby such fines are more successful in agglomeration based on collisions than larger particles (van den Dries andVromans, 2002, 2003).…”

Section: Distribution Of Apimentioning

confidence: 72%

“…Hydrophobic materials may segregate from neighboring hydrophilic components in the presence of a hydrophilic granulating agent, resulting in de-mixing as granule growth occurs (Zhang et al, 2002). The influence of the hydrophobicity of powder ingredients was only recently examined in twin screw granulation in a study using dicalcium phosphate blended into a formulation with lactose and microcrystalline cellulose (Yu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder

Thompson

O’Donnell

2015

International Journal of Pharmaceutics

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Wettability of pharmaceutical solids: its measurement and influence on wet granulation

Cited by 63 publications

References 17 publications

Determination of surface heterogeneity of d-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography

Determination of surface heterogeneity of d-mannitol by sessile drop contact angle and finite concentration inverse gas chromatography

Product‐centered processing: Pharmaceutical tablets and capsules

Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder

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