West Nile fever on the territory of the Moscow agglomeration

Климова, Е А; Karetkina, G N; Shakaryan, Armen K.; Сайфуллин, М. А.; Karan, Ludmila S.; Larichev, Victor; Grigoreva, Ya.E.; Morozkin, Evgeny S.; Lyapeykova, E.A.; Abramova, E.N.; Гусева, Г Д; Posukhovsky, E.A.; Ilina, M.A.; Смирнова, Т. Д.; Chentsov, V.B.; Tsvetkova, Nataliya A.; Antipyat, N. A.; Базарова, М. В.; Krasnova, S.V.; Smetanina, S.V.; Yushchuk, N D

doi:10.33029/2305-3496-2021-10-4-13-21

Cited by 3 publications

(1 citation statement)

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“…This suggests that the circulation of insect-specific viruses in mosquitoes may influence the spread of mosquito-borne viruses that are already known and pathogenic to humans. The expansion of West Nile virus’ range border to the north has increased the severity of this problem [ 61 ]. At the same time, the host’s innate immune system responds differently to viral infections.…”

Section: Introductionmentioning

confidence: 99%

Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)

Kholodilov,

Aibulatov,

Khalin

et al. 2024

Viruses

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In the last few years, there has been a dramatic increase in the number of discovered viruses that are transmitted by arthropods. Some of them are pathogenic for humans and mammals, and the pathogenic potential of others is unknown. The genus Orthoflavivirus belongs to the family Flaviviridae and includes arboviruses that cause severe human diseases with damage to the central nervous system and hemorrhagic fevers, as well as viruses with unknown vectors and viruses specific only to insects. The latter group includes Lammi virus, first isolated from a mosquito pool in Finland. It is known that Lammi virus successfully replicates in mosquito cell lines but not in mammalian cell cultures or mice. Lammi virus reduces the reproduction of West Nile virus during superinfection and thus has the potential to reduce the spread of West Nile virus in areas where Lammi virus is already circulating. In this work, we isolated Lammi virus from a pool of adult Aedes cinereus mosquitoes that hatched from larvae/pupae collected in Saint Petersburg, Russia. This fact may indicate transovarial transmission and trans-stadial survival of the virus.

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Section: Introductionmentioning

confidence: 99%

Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)

Kholodilov,

Aibulatov,

Khalin

et al. 2024

Viruses

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Optimization of scientifico-practical aspects of West Nile fever causative agent’s monitoring (by the example of the Volgograd region)

Никитин

Удовиченко

Putintseva

et al. 2023

Med. vestn. Ûga Ross.

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Objective: to assess the quality and effectiveness of West Nile fever (WNF) causative agent’s monitoring in the Volgograd region and to develop a set of measures to its optimization. Materials and methods: data on the detection of WNV cases, results of serological and zooentomological monitoring in 2009–2021. A comprehensive methodological approach was applied, including statistical and epidemiological methods. Results: based on the assessment of WNF causative agent’s monitoring key aspects in the Volgograd region, it was shown that one of the priority problems is the insufficient and untimely detection of cases among the population. Among the urgent problems of serological monitoring are the lack of a clearly established frequency of serological examination in the population of the region’s administrative territories and the termination of one of the indicator population groups examination, regulated by the current regulatory and methodological documents. An assessment of the parameters of monitoring studies of the external environment indicates an insufficient territorial coverage and a decrease in the volume of studies, primarily in relation to the main carriers of the West Nile virus, which determines the overall low detection rate of West Nile virus markers. Conclusion: recommendations are proposed for optimizing monitoring, which will enhance the efficiency of WNF epidemiological surveillance and develop a scientifically based forecast of the development of the epidemiological situation.

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Study of the circulation and properties of the West Nile virus in Russia in 2022

Toporkov,

Putintseva,

Udovichenko

et al. 2024

Journal of microbiology, epidemiology and immunobiology

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Introduction. The relevance of the study is due to the need to assess the real expansion of West Nile fever (WNF) in Russia, analyze the manifestations of epizootic and epidemic processes and study the population structure of West Nile virus (WNV). Aim. To obtain objective data on the intensity of WNV circulation in certain territories of Russia and study the properties of the isolated strains of the pathogen. Materials and methods. 4564 samples of field material from 23 subjects of the Russian Federation and 1547 samples of clinical material from 12 subjects of the Russian Federation were examined. A set of laboratory diagnostic methods was used: ELISA, RT-PCR, virological, sequencing. Results. In 20 out of 1331 (1.5%) examined febrile patients, IgM antibodies to WNV were detected, including positive cases identified for the first time in the Karachay-Cherkess Republic, Tver and Vladimir regions. The presence of immunity to WNV was found on average in 8.6% of 11 federal subjects' population with high seroprevalence rates in Zaporozhye (24,5%), Tula (15,4%) and Kursk (11,1%) regions. Low-avidity IgG antibodies were detected in 44 (33,1%) samples from a population of 9 federal subjects. Intensive circulation of WNV lineage 2 in the epizootic cycle in the southern part of European Russia was confirmed. 12 WNV isolates were obtained, including those isolated for the first time in the Republic of Crimea, the Karachay-Cherkess Republic and the Stavropol Territory. The heterogeneity of circulating WNF causative agent's strains related to the two clades of the WNV lineage 2 formed in 2021 and 2022 was established. Conclusion. In the course of comprehensive monitoring studies, a new northern border of the WNF range was established, which as of 2022 passes through the territory of the Tver region. Data from seroepidemiological studies, including the detection of low-avidity IgG antibodies, confirm fairly intense, but undiagnosed contact of the population of the European part of Russia with the WNF pathogen. In the southern region of the European part of Russia, WNV genotype 2 predominantly circulates, belonging to at least two clades formed in 2021 and 2022.

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West Nile fever on the territory of the Moscow agglomeration

Cited by 3 publications

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Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)

Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)

Optimization of scientifico-practical aspects of West Nile fever causative agent’s monitoring (by the example of the Volgograd region)

Study of the circulation and properties of the West Nile virus in Russia in 2022

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