Wernicke's encephalopathy in Crohn's disease and ulcerative colitis

Oudman, Erik; Wijnia, Jan W.; Oey, Misha J.; Dam, Mirjam van; Postma, Albert

doi:10.1016/j.nut.2021.111182

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…It was reported that some clinicians erroneously thought that these bags contained adequate micronutrients and thus omitted their addition [17]. When WE is suspected, rapid treatment with high doses of thiamine is still a lifesaving measure to ameliorate WE [3,12]. The recommended dosage is 500 mg given intravenously three times a day for two to three days; additional treatment doses may be administered based on the clinical response [2,18,20].…”

Section: Discussionmentioning

confidence: 99%

“…I report the case of a 51-year-old male on long-term TPN because of small bowel obstruction (SBO) who developed WE due to a lack of vitamin supplementation during the nulla per os (NPO) period. This case highlights the importance of appropriate vitamin supplementation for patients on longterm TPN, and rapid treatment with high doses of thiamine, when there is any clinical suspicion of WE in those patients [12]. This case study was conducted according to the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board of Inha University Hospital (no.…”

Section: Introductionmentioning

confidence: 99%

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Development of Wernicke’s Encephalopathy during Total Parenteral Nutrition Therapy without Additional Multivitamin Supplementation in a Patient with Intestinal Obstruction: A Case Report

2022

Ann Clin Nutr Metab

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Wernicke's encephalopathy (WE) is a serious neurological disorder that can be fatal if not properly treated. In this current paper, I present the case of a 51-year-old male with a perivesical fistula between a presacral abscess and the rectus abdominis muscle. He received total parenteral nutrition therapy during a fasting period because of small bowel obstruction and later developed WE. The patient's WE-related symptoms improved following rapid treatment with high doses of thiamine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Wernicke’s Encephalopathy during Total Parenteral Nutrition Therapy without Additional Multivitamin Supplementation in a Patient with Intestinal Obstruction: A Case Report

2022

Ann Clin Nutr Metab

View full text Add to dashboard Cite

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“…European Federation of Neurological Societies (EFNS) recommended either intramuscular injection or intravenous supplementation of thiamine (200 mg thrice-daily) before glucose supplement [3]. Recent studies recommended high dose supplementation of thiamine at least 500 mg per day for more than three days [15,16], suggesting higher doses of thiamine given parenterally have the potential to reverse WE. The dose in this case was "100 mg twice-daily" by intramuscular injection in the first four days, then "200 mg twice-daily" by intravenous administration for another 2 days, and finally turned to "200 mg twice-daily" by intramuscular injection under the guidance of physicians from the Department of Nutriology.…”

Section: Discussionmentioning

confidence: 99%

Crohn’s Disease with Wernicke’s Encephalopathy: A Case Report and Literature Review

Lv¹,

Zhao²,

Tang³

et al. 2021

JJGH

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Wernicke's Encephalopathy (WE) is an acute and potentially life-threatening neurological disorder due to thiamine deficiency. The classical signs and symptoms of the disorder include ophthalmoplegia, ataxia, and mental confusion. Although WE is known to occur frequently in alcoholics, it has also been reported in a number of non-alcoholic causes. Here, we reported a rare case of a severely malnourished patient with Crohn's Disease (CD) who presented WE after prolonged total parenteral nutrition without thiamine supplementation. This case revealed that it is of importance to give thiamine supplementation for malnourished patients even though they are not alcoholics. This article also reviews cases of CD and WE to discuss the diagnostic evaluation and clinical treatment of WE.

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“…Oudman et al. ( 26 ) performed a case review of the emerging WE in IBD and noted that rapid treatment with high-dose thiamine (500 mg, 3 times/d) was lifesaving and relieved the core symptoms of WE.…”

Section: Vitaminsmentioning

confidence: 99%

Adjunctive therapeutic effects of micronutrient supplementation in inflammatory bowel disease

Liu

Dong

2023

Front. Immunol.

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Growing evidence suggests that micronutrient status may have some impact on the course of inflammatory bowel disease (IBD). However, micronutrient deficiencies are easily overlooked during the treatment of IBD patients. There have been many studies on micronutrient supplementation, in which several clinical trials have been conducted targeting vitamin D and iron, but the current research is still preliminary for other vitamins and minerals. This review provides an overview of the adjunctive therapeutic effects of micronutrient supplementation in IBD, to summarize the available evidence, draw the attention of clinicians to micronutrient monitoring and supplementation in patients with IBD, and also provide some perspectives for future research directions.

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Wernicke's encephalopathy in Crohn's disease and ulcerative colitis

Cited by 19 publications

References 43 publications

Development of Wernicke’s Encephalopathy during Total Parenteral Nutrition Therapy without Additional Multivitamin Supplementation in a Patient with Intestinal Obstruction: A Case Report

Development of Wernicke’s Encephalopathy during Total Parenteral Nutrition Therapy without Additional Multivitamin Supplementation in a Patient with Intestinal Obstruction: A Case Report

Crohn’s Disease with Wernicke’s Encephalopathy: A Case Report and Literature Review

Adjunctive therapeutic effects of micronutrient supplementation in inflammatory bowel disease

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