Wernicke’s encephalopathy

Robinson, Karen

doi:10.7748/en2003.09.11.5.30.c1134

Cited by 4 publications

(3 citation statements)

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“…A striking feature was the loss of Purkinje cells with atrophy and gliosis of the cerebellum [17]. Neurological involvements of CD were first attributed to malabsorption due to changes in the mucosal architecture of the small intestine [18]. [20].…”

Section: History and Demographymentioning

confidence: 99%

Neurological Manifestations of Celiac Disease

Pishva

Haghighi

Ashkani-Esfahani

et al. 2013

GMJ

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Celiac disease (CD) is a rare malabsorption syndrome mainly occurring in childhood which is now recognized as the most common food intolerance disease in the world. CD is associated with a wide spectrum of extra intestinal manifestations. Neurological involvements of CD were first attributed to malabsorption due to changes in the mucosal architecture of the small intestine. Neurological manifestations were more frequent in middle-aged adults, but were rare in children. The most common central nervous system manifestations include cerebellar malfunctions, seizures, dementia, multiple sclerosis like presentations, motor neuron diseases, headaches, movement disorders, and neuro-psychiatric presentations. On the other hand, the peripheral nervous system involvement includes different types of peripheral neuropathies and muscular involvements. In this study, we embarked on a short review to go through the neurological presentations and problems of CD.

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Section: History and Demographymentioning

confidence: 99%

Neurological Manifestations of Celiac Disease

Pishva

Haghighi

Ashkani-Esfahani

et al. 2013

GMJ

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“…Thiamine deficiency is rare, but may sometimes occur if there is concomitant alcohol abuse and dependency in addition to the celiac disease (especially if, for any reason, intravenous dextrose is administered alone). A disorder virtually identical to the Wernicke-Korsakoff syndrome with opthalmoplegia, ataxia and confusion may develop (7). Recognition may be difficult because the syndrome can occur alone and diagnostic delay may result in impaired short-term memory.…”

Section: Vitamin Deficiency Syndromesmentioning

confidence: 99%

Neurological Disorders in Adult Celiac Disease

Freeman

2008

Canadian Journal of Gastroenterology

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Celiac disease may initially present as a neurological disorder. Alternatively, celiac disease may be complicated by neurological changes. With impaired nutrient absorption, different deficiency syndromes may occur and these may be manifested clinically with neurological changes. However, in patients with deficiency syndromes, extensive involvement of the small intestine with celiac disease is often evident. There are a number of reports of celiac disease associated with neuropathy, ataxia, dementia and seizure disorder. In these reports, there is no clear relationship with nutrient deficiency and a precise mechanism for the neurological changes has not been defined. A small number of patients have been reported to have responded to vitamin E administration, but most do not. In some, gluten antibodies have also been described, especially in those with ataxia, but a consistent response to a gluten-free diet has not been defined. Screening for celiac disease should be considered in patients with unexplained neurological disorders, including ataxia and dementia. Further studies are needed, however, to determine if a gluten-free diet will lead to improvement in the associated neurological disorder.

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“…Wernicke-Korsakoff's syndrome is characterised by opthalmoplegia, ataxia and confusion. 12 These symptoms can occur in isolation, leading to difficulty in diagnosis. Any delay in recognition and treatment may lead to permanent, profound impairment of short-term memory.…”

Section: The Gut Malabsorptionmentioning

confidence: 99%