Neurological Disorders in Adult Celiac Disease

Abstract

Celiac disease may initially present as a neurological disorder. Alternatively, celiac disease may be complicated by neurological changes. With impaired nutrient absorption, different deficiency syndromes may occur and these may be manifested clinically with neurological changes. However, in patients with deficiency syndromes, extensive involvement of the small intestine with celiac disease is often evident. There are a number of reports of celiac disease associated with neuropathy, ataxia, dementia and seizure disorder. In these reports, there is no clear relationship with nutrient deficiency and a precise mechanism for the neurological changes has not been defined. A small number of patients have been reported to have responded to vitamin E administration, but most do not. In some, gluten antibodies have also been described, especially in those with ataxia, but a consistent response to a gluten-free diet has not been defined. Screening for celiac disease should be considered in patients with unexplained neurological disorders, including ataxia and dementia. Further studies are needed, however, to determine if a gluten-free diet will lead to improvement in the associated neurological disorder.

Association of Multiple Sclerosis and Celiac Disease: Case Report

“…Among the most com mon ne u rolo gi cal prob lems as so ci a ted with CD are pe rip he ral ne u ro pathy, ce re bel lar ata xi a, epi lepsy, de men ti a, mul tip le scle ro sis, ne u rom ye li tis op ti ca and mig rai ne. 8,9 Dep res si on and ot her psychi at ric symptoms ha ve al so be en re por ted as com mon comp li ca ti ons of CD oc cur ring in abo ut one third of pa ti ents. Com mon symptoms inc lu de apathy, ex ces si ve anxi ety and ir ri ta bi lity.…”

“…Com mon symptoms inc lu de apathy, ex ces si ve anxi ety and ir ri ta bi lity. 8 Ne u ro lo gi cal symptoms may be re la ted to me ta bo lic, ge ne tic, im mu no lo gic and nut ri ti o nal fac tors. 8 In CD, se ve ral an ti bo di es can be me a su red such as AGA, an ti-EMA, an ti-tTG and an ti-re ti cu lin (ARA).…”

“…8 Ne u ro lo gi cal symptoms may be re la ted to me ta bo lic, ge ne tic, im mu no lo gic and nut ri ti o nal fac tors. 8 In CD, se ve ral an ti bo di es can be me a su red such as AGA, an ti-EMA, an ti-tTG and an ti-re ti cu lin (ARA). 10 The im pro ve ment with glu ten-fre e di et and the ab nor ma li ti es in the small in tes ti ne bi opsy are di ag nos tic.…”

Deficiencia de micronutrientes y enfermedad celíaca en pediatría

“…[29][30][31][32] Hay escasos estudios en niños y mínima evidencia respecto de la aparición de la signología clínica neurológica. Un estudio de nuestro grupo algunas décadas atrás 22 mostró que niños preescolares con EC tenían concentraciones de Cu en pelo y no en plasma significativamente menores que niños sin EC.…”

Celiac Disease Presenting with Motor Weakness

“…Among these ataxia and peripheral neuropathy are the commonest. Less common manifestations include myoclonus, seizures, dementia, encephalitis, myopathy and neuromyotonia (3,4,7). These are estimated to occur in up to 6-10% of patient with proved-celiac disease.…”