Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D‐related 11 in Eastern Hungarians

Abstract

BACKGROUND. Using serologic human lymphocyte antigen (HLA) typing, the authors previously described a strong association between well differentiated thyroid carcinoma and HLA D-related 1 (HLA-DR1) in a population of unselected patients from Eastern Hungary. METHODS. In the current study, the authors used polymerase chain reaction-single strand conformational polymorphism to determine the HLA-DR type in 75 patients with well differentiated thyroid carcinoma from the same area as their previous population, and they compared the current results with the results from a group of 170 healthy controls. RESULTS. A significant increase in HLA-DR11, rather than HLA-DR1, was observed in patients with well differentiated thyroid carcinoma among a population of patients from the same area that was studied previously. After excluding technical reasons to account for differences in disease association, they postulated that interim environmental factors, possibly radiation fallout , may have resulted in differences in genetic susceptibility to thyroid carcinoma. Consideration of the potential antigenic peptides that may be restricted by the two HLA-DR alleles may have allowed for the binding of similar peptides to initiate an immune response, likely leading to progressive immunomodulation of the tumor. Discriminat function analysis indicated a significant relation between tumor size and metastases and less lymphocytic infiltration of the tumor, but this was not related to HLA-DR phenotypes. CONCLUSIONS. The authors found that the study of major histocompatability complex alleles holds promise for understanding the events that initiate and maintain tumor immunomodulation.

HLA-DR Association in Papillary Thyroid Carcinoma

“…The immune system has a complex effect on tumors behavior, limiting its progression or sometimes inducing further tumor growth [6]. In this study we have found an association between HLA-DRB1*04 and papillary thyroid carcinoma in an Iranian population.…”

“…A highly significant association between HLA-DR1 and thyroid carcinoma in an Italian population has been reported [9]. Association between HLA-DR1 and papil- lary thyroid carcinoma has also been reported in Hungarian population [6]. In another study in Spanish population an association has been reported between HLA-DR11 and papillary thyroid carcinoma [6].…”

“…Association between HLA-DR1 and papil- lary thyroid carcinoma has also been reported in Hungarian population [6]. In another study in Spanish population an association has been reported between HLA-DR11 and papillary thyroid carcinoma [6]. The discrepancies in the previous findings on different HLA-DR associations and thyroid carcinoma are probably due the ethnic or geographic differences or in some cases might be due to the small sample size studied [15,17].…”

“…Therefore an approach for better understanding of the mechanism of immune system response in thyroid carcinoma may be helpful in finding better strategies and new treatment options [6].…”

Parathyroid Chief Cell Adenoma Associated with Massive Chronic Parathyroiditis in a Woman with Hyperparathyroidism

“…These authors claimed that the inflammation might have been due to local tissue response to the parathyroid adenoma. In other endocrine tumors, the presence, significance, and cause of chronic inflammation were the subject of numerous studies [9][10][11].…”