Well-being and depression in individuals with subclinical hypothyroidism and thyroid autoimmunity—A general population study

Abstract

Elevated anti-TPO levels cannot be used as a general marker of poor well-being or depression in the general population.

Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia

“…In another study, Medici et al found an association between low-normal TSH within the reference range and risk of developing depression independently of gender, and confirmed in prospective analysis (Medici et al, 2014). But other studies found no association between thyroid dysfunction and depression (Beydoun et al, 2013; Engum et al, 2005; Fjaellegaard et al 2015; Saltevo et al, 2015; van de Ven et al, 2012). The methodological approaches, the test used to assess the depression, and the different sample size used in the various studies might partly justify the contrasting results.…”

Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism

“…In some studies, patients with thyroid failure and euthyroid patients with Hashimoto's thyroiditis seemed to be more prone to the development of depression. However, other authors observed no association between mild hypothyroidism and the presence of depression and found that in the general population, positive antibodies against thyroid peroxidase (TPOAb) cannot be used as a general marker of poor well‐being or depression …”

Depression, Well-being and Hypothyroidism

“…Moreover, Thyroid peroxidase antibodies (TPO) have been linked to depressive states. Depression is variable and is prejudiced by vulnerability and the gradation, though not always, of thyroid catastrophe [3].…”

“…All of the three studies have a small sample size and have high chances of selection bias. A large sample size, unselected cohorts with thyroid antibody assessment are essential for the resolution of this issue [3,11].…”