Welders' pneumoconiosis: tissue elemental microanalysis by energy dispersive x ray analysis.

Funahashi, Akira; Schlueter, Donald P.; Pintar, Karl; Bemis, Edwin L.; Siegesmund, Kenneth A.

doi:10.1136/oem.45.1.14

Cited by 24 publications

(20 citation statements)

References 16 publications

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“…Funahashi et al observed moderate to pronounced fibrosis in 5 of 10 symptomatic welders. In these individuals, energy-dispersive X-ray analysis showed a large amount of iron in the lungs and no silica, eliminating coexisting silicosis as the etiology of the fibrosis (129). Although no specific treatment exists, removal of iron particles by BAL has been attempted in a welder with siderosis to prevent further fibrosis (130).…”

Section: Ironmentioning

confidence: 99%

Inorganic Dust Pneumonias: The Metal-Related Parenchymal Disorders

Kelleher¹,

Pacheco²,

Newman³

2000

Environmental Health Perspectives

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In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metal-induced parenchymal lung disorders. Inhalation of metal dusts and fumes can induce a wide range of lung pathology, including airways disorders, cancer, and parenchymal diseases. The emphasis of this update is on parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. The clinical characteristics, epidemiology, and pathogenesis of disorders arising from exposure to aluminum, beryllium, cadmium, cobalt, copper, iron, mercury, and nickel are presented in detail. Metal fume fever, an inhalation fever syndrome attributed to exposure to a number of metals, is also discussed. Advances in our knowledge of antigen-specific immunologic reactions in the lung are particularly evident in disorders secondary to beryllium and nickel exposure, where immunologic mechanisms have been well characterized. For example, current evidence suggests that beryllium acts as an antigen, or hapten, and is presented by antigen-presenting cells to CD4+ T cells, which possess specific surface antigen receptors. Other metals such as cadmium and mercury induce nonspecific damage, probably by initiating production of reactive oxygen species. Additionally, genetic susceptibility markers associated with increased risk have been identified in some metal-related diseases such as chronic beryllium disease and hard metal disease. Future research needs include development of biologic markers of metal-induced immunologic disease, detailed characterization of human exposure, examination of gene alleles that might confer risk, and association of exposure data with that of genetic susceptibility. Key words: aluminum, beryllium, cadmium, cobalt, copper, hard metal disease, iron, mercury, metal fume fever, nickel, pneumoconiosis.-Environ Health Perspect 1 08(suppl 4):685-696 (2000). http.//ehpnetl.niehs.nih.gov/docs/2000/suppl-4/685-696kelleher/abstract.html The term pneumoconiosis, first introduced in the 19th century, refers to diseases and patho-logic consequences from inhalation of particulate dusts. In recent years the greatest progress in our understanding of pneumoconioses, other than those produced by asbestos, silica, and coal, has been in the arena of metal-induced parenchymal lung disorders. As presented in Table 1, various metal dusts and fumes can induce a wide range of lung pathology , including not only parenchymal diseases but airways disorders and cancer as well. In this update we emphasize the parenchymal diseases caused by metal inhalation, including granulomatous disease, giant cell interstitial pneumonitis, chemical pneumonitis, and interstitial fibrosis, among others. Although a number of metals, in addition to those discussed in this chapter, are associated with various forms of lung injury, we have focused this discussion on those for which there has...

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Section: Ironmentioning

confidence: 99%

Inorganic Dust Pneumonias: The Metal-Related Parenchymal Disorders

Kelleher¹,

Pacheco²,

Newman³

2000

Environmental Health Perspectives

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“…Some authors have postulated that these rare cases are secondary to concomitant inhalation of silicates or asbestos that can occur in many occupations associated with exposure to iron [ 4 ]. However, Funahashi et al challenged this view after investigating 10 symptomatic welders and performing energy dispersive X-ray analysis on lung tissue for elemental content [ 5 ]. Despite demonstrating restrictive defects in seven of their patients, and mild to moderate airway obstruction in a further two, they found no difference between the pulmonary silicon content of patients with symptomatic 'welders' pneumoconiosis' and that of age-matched control lungs [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report

2008

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Introduction: Pulmonary siderosis secondary to the inhalation of iron compounds is a rare condition which, despite striking radiological and histopathological features, has not traditionally been associated with symptoms or functional impairment. Although not the first of its kind, we present an unusual case of pulmonary siderosis with symptomatic respiratory disease, most likely secondary to associated fibrosis.

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“…In these individuals, energy-dispersive X-ray analysis showed a large amount of iron in the lungs and no silica, eliminating coexisting silicosis as the etiology of the fibrosis. [7] However, people exposed to iron dust and fumes may also be exposed to silica and asbestos, as well as other silicates, depending on the work activity. In this situation, it is called mixed type pneumoconiosis, such as siderosilicosis.…”

Section: Discussionmentioning

confidence: 99%

Nonfibrinogenic Pneumoconiosis, Siderosis: A Case Report

Doğrul

2017

EJMI

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Welders' pneumoconiosis: tissue elemental microanalysis by energy dispersive x ray analysis.

Cited by 24 publications

References 16 publications

Inorganic Dust Pneumonias: The Metal-Related Parenchymal Disorders

Inorganic Dust Pneumonias: The Metal-Related Parenchymal Disorders

Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report

Nonfibrinogenic Pneumoconiosis, Siderosis: A Case Report

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