Welcome to the third issue of JCJP!

Abstract

Lisa Fortier, and help build the journal's reputation as a leading publication in joint preservation and cartilage regeneration. Given the open access nature of this journal, the ability for clinicians, researchers, and students to publish in a timely fashion in a peer-reviewed setting is seemingly unlimited. We anticipate that JCJP will have a global impact in the near term. The mission of JCJP aligns perfectly with the mission of ICRS -to advance science and education for the prevention and treatment of cartilage disease worldwide.In this issue, we have several outstanding articles from thought leaders in joint preservation from around the globe. First, we have an article by ICRS past-president Professor Alberto Gobbi and colleagues entitled "A Review of Bone Marrow Lesions in the Arthritic Knee and Description of a Technique for Treatment . " 1 In this article, the authors discuss the etiology and types of bone marrow lesions, as well as the biology and biomechanics of these lesions along with relevant anatomy. Treatment options for these difficult entities are also reviewed, including a description of the technique and benefits of a novel minimally invasive procedure to induce bone remodeling referred to as Osteo-Core-Plasty. Next, we have an article from the lab of ICRS past-president Dr. Lisa Fortier (and prior editor-in-chief) entitled "Bone marrow concentrate mesenchymal stromal cells do not correlate with nucleated cell count or colony forming units. " 2 Point-ofcare bone marrow aspirate concentrate has become a more frequently used biologic treatment for cartilage repair and osteoarthritis given its bioactive components. Measuring the concentration of mesenchymal stromal cells in bone marrow aspirate concentrate is difficult, yet critical for determining their specific influence on healing. This article describes a study in which the authors analyzed two proposed techniques, nucleated cell count and colony forming units, that more simply quantify MSC concentration as compared to advanced methods. Next, the role of adipose is discussed in an article led by Hannah Bradsell, entitled "The Essential Roles of Human Adipose Tissue: Metabolic, Thermoregulatory, Cellular, and Paracrine Effects . " 3 In this article, the authors describe the various roles of human adipose tissue, including the important functions of adipose-derived mesenchymal stromal cells, which contain several biologic properties that exhibit paracrine and immunomodulatory functions, as well as the ability to differentiate into multiple lineages, including chondrogenic and osteogenic cell lines. This article discusses the anatomy, physiology, and various roles and properties of human adipose tissue to better understand this tissue before considering it as a cellular source. The next article in this issue is led by Dr. Nguyen Huu Chien and colleagues, entitled "The Need for a Standardized Whole Leg Radiograph Guideline: The Effects of Knee Flexion, Leg Rotation, There is a high risk of developing knee osteoarthritis in patients with lower lim...

Orthopedic Joint Preservation: A Comprehensive Review

“…The articular cartilage of the joint has limited healing capacity, making the repair of cartilage damage challenging. Various treatment modalities, including lifestyle modification, pharmacotherapy, physiotherapy, and osteobiologics, are available for articular cartilage damage [42]. However, conclusive clinical evidence is still lacking, and further research is needed to understand the potential and limitations of these innovative treatments [12].…”