Welche Akzeptorphase ist am ehesten repräsentativ für die Hornschicht bei in vitro‐Messungen der Wirkstoffabgabe aus Externa?

Abstract

The seeds of Brassica sp. are known to have characteristic sterol composition in containing a larger amount of brassicastero12e72*, and the finding in this study of trans-22-dehydrocholesterol and stigmasta-5,25-dienol, which are regarded indeed as the natural products rather than the artefacts, in B. napus seed oil is of interest from the standpoint of sterol biogenesis.N o m e n c l a t u r e "Campesterol" is a mixture of 24a-and 24fi-methylcholesterol 28, and "campestanol" described here is con-*% W . R. Nes and M . L. McKean, Biochemistry of Steroids and Other Isopentenoids, University Park Press, Baltimore, MA 1977.sidered not 24a-methylcholestanol alone but a mixture of 24a-and 24p-epimers 28; brassicasterol = 24fi-methyltrans-22-dehydrocholesterol; stigmastanol = 24~-ethylcholestanol; sitosterol = 24a-ethylcholesterol; stigmasterol = 24u-ethyl-trans-22-dehydrocholesterol; stigmasta-5,25-dienol = 24~-ethyl-25(27)-dehydrocholesterol; fucosterol = cis-24-ethylidenecholesterol; 28-isofucosterol = trans-24-ethylidenecholesterol.

Selection of the Acceptor Medium in in vitro Measurements of Drug Release from Dermatological Ointments

“…It corresponds to the sebaceous gland secretion [5], Another example are the keratoplastic drugs like salicylic acid. Our investigations comparing in vitro drug release with in vivo studies revealed that a li pophilic acceptor medium is most represen tative for the physiologic acceptor medium [6], A topical effect is also the aim of antimicrobial therapy for mycotic or bacte rial skin infections. Here the acceptor medium must be differently characterized depending on whether oozing skin altera tions or hyperkeratosis prevails.…”