Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women.

Eckel, Robert H.; Yost, Trudy J.

doi:10.1172/jci113193

Cited by 76 publications

(41 citation statements)

References 28 publications

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“…Our ®ndings in women, but not in men, are concordant with previous observations. 7,15,16 Indeed, one study exclusively composed of men 18 and another that included six men and three women 19 have already reported an increase in AT-LPL activity after weight loss. It is possible that such discrepancy could be due to the substantial mean weight loss (16 and 43 kg) reported in the two previous studies, as already hypothesized.…”

Section: Discussionmentioning

confidence: 99%

Effect of a moderate weight loss on adipose tissue lipoprotein lipase activity and expression: existence of sexual variation and regional differences

Imbeault¹,

Alméras²,

Richard

et al. 1999

Int J Obes

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OBJECTIVE: To evaluate the impact of moderate body weight loss on both adipose tissue lipoprotein lipase (AT-LPL) activity and expression and to verify whether variation in AT-LPL could be related to changes in lipid ± lipoprotein metabolism. DESIGN: Intervention study of a 15-week weight reducing program (energy de®cit: 500 ± 800 kcalad below the subjects' estimated sedentary energy expenditure). SUBJECTS: Thirty two obese subjects (14 men and 18 premenopausal women; aged 36 ± 50 y) whose body fatness ranged from 34 to 54% fat. MEASUREMENTS: Adipose tissue biopsies from the abdominal and femoral depots, various fatness and fat distribution parameters (computed tomography and anthropometry), fasting plasma concentrations of high-and low-density lipoprotein cholesterol (HDL-C, LDL-C), and triglycerides at baseline and 4 ± 6 weeks after the 15-week weight reducing program, when subjects were weight stable. RESULTS: In response to weight loss, AT-LPL activity of both regions did not change in men, but decreased in women. Regarding AT-LPL expression, no interaction between time and sex was observed in response to the treatment. In both genders, the higher was the basal AT-LPL activity, the greater was the reduction of this enzyme activity in response to weight loss, in both the abdominal and femoral depots ( 7 0.53`r`7 0.84, P values ranging from 0.0001 to 0.05). Body weight loss promoted a signi®cant reduction in plasma triglyceride (TG), insulin and LDL-cholesterol (C) concentrations in men whereas only plasma TG and LDL-C levels were decreased in women (P`0.05). Although the average reduction in HDL-C levels in response to weight loss was not signi®cant, the higher was the decrease in femoral AT-LPL activity, the greater was the reduction in plasma HDL-C levels (r 0.50, P`0.05) in response to weight loss, in women. An inverse relationship was observed between changes in femoral AT-LPL activity and HDL-C levels variation in men (r 7 0.64, P`0.05). CONCLUSION: (1) variation in AT-LPL activity differs between men and women in response to moderate body weight loss although the corresponding enzyme mRNA levels remain unchanged; and (2) changes in femoral AT-LPL activity are related to weight loss induced variation in plasma HDL-C concentrations.

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Section: Discussionmentioning

confidence: 99%

Effect of a moderate weight loss on adipose tissue lipoprotein lipase activity and expression: existence of sexual variation and regional differences

Imbeault¹,

Alméras²,

Richard

et al. 1999

Int J Obes

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“…Thus, infrequent eating concentrated in the evening may be involved in weight gain (Fricker et al 1990). This factor may be related to circadian changes in insulin secretion; insulin levels tending to be higher in the latter part of the day (Apfelbaum et al 1972), resulting in greater uptake of fatty acids by adipocytes (Eckel & Yost, 1987).…”

Section: How Could Frequent Eating Help Body-weight Control?mentioning

confidence: 99%

Role of dietary carbohydrate and frequent eating in body-weight control

Kirk

2000

Proc. Nutr. Soc.

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Despite widespread interest in body-weight control, the prevalence of obesity continues to rise worldwide. Current public health advice for obesity prevention is clearly failing. The present paper examines the appropriateness of current public health advice for body-weight control, i.e. to reduce consumption of fatty foods, to reduce consumption of sugar and to avoid snacking between meals. An increase in carbohydrate : fat ratio should improve body-weight control, as high-carbohydrate low-fat diets are less likely to lead to overeating, and if overeating does occur, less of the excess energy is likely to be stored as fat. However, it is suggested that for the long-term prevention of weight gain, advice to increase consumption of carbohydrate-rich foods may be more effective than advice which focuses on reducing consumption of fatty food. Moreover, in view of the inverse relationship between fat and sugar intakes, sugar may have a positive role to play in body-weight control in facilitating an increase in carbohydrate : fat ratio. Snacking for most individuals appears not to adversely affect body-weight control, and for some it may improve control. This situation may exist because frequent eating helps appetite control, thus preventing overeating at meals, and as snacks overall tend to be higher in carbohydrate and lower in fat than meals, frequent eating may be a strategy for increasing carbohydrate : fat ratio. It is also suggested that eating ‘little and often’ may be a more compatible pattern of eating for a physically-active lifestyle than eating large meals. Perhaps the most appropriate advice on food intake that would work synergistically with concurrent advice to increase physical activity is to eat more carbohydrate, and to eat frequently.

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“…Hill et al (15) and Wheeler et al (39) found that AT-LPL activity is higher in weight cycled rats than in control rats both at the end of a weight cycling period and during the refeeding period. In obese humans, AT-LPL activity levels are elevated compared to normal weight controls (8,34). However, after weight reduction, AT-LPL levels are further elevated (30).…”

Section: Introductionmentioning

confidence: 99%

Long‐Term Weight Cycling in Female Wistar Rats: Effects on Metabolism

Buison

Uhley

et al. 1995

Obesity Research

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LU, HUIQING, ANNE BUlSON, VIRGINIA UHLEY AND K-L CATHERINE JEN. Long-term weight cycling in female Wistar rats: effects on metabolism. Obes Res. 1995;3:521-530. Weight cycling (We) induced by ad-lib and restricted high fat (HF) feeding has been shown to reduce final body weight but not body fat percent in female Wistar rats. We examined the metabolic consequences of this type of WC. Five groups of female Wistar rats were fed a HF diet and the sixth group was fed a low fat diet to serve as a control group. Of the five HF groups, four groups were weight cycled by ad-lib and restricted feeding of the HF diet. One of these groups weight cycled three times (HFCYC group) while the remaining three groups weight cycled once only, corresponding to the first, second and the third cycle of the HFCYC group. HF feeding induced hyperinsulinemia, hypertriglyceridemia, insulin resistance and elevated adipose tissue lipoprotein lipase (AT -LPL) activity levels as compared to rats fed the low fat (LF) control diet. WC further increased blood insulin concentrations and insulin resistance in rats with three cycles of WC. However, blood pressure was not affected by HF feeding or WC. The magnitude of increase of AT-LPL was reduced in weight cycled, HF fed obese rats after 15 weeks refeeding. We concluded that even though WC did not enhance weight gain nor impair weight loss, it did facilitate the development of . insulin resistance and may predispose animals to diabetes.

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Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women.

Cited by 76 publications

References 28 publications

Effect of a moderate weight loss on adipose tissue lipoprotein lipase activity and expression: existence of sexual variation and regional differences

Effect of a moderate weight loss on adipose tissue lipoprotein lipase activity and expression: existence of sexual variation and regional differences

Role of dietary carbohydrate and frequent eating in body-weight control

Long‐Term Weight Cycling in Female Wistar Rats: Effects on Metabolism

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