Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

Abstract

Lactobacillus plantarum ZJUFT17 (T17) is a potential probiotic bacterium isolated from Chinese traditional sourdough. The purpose of this study was to investigate its weight-reducing effects in mice fed a high-fat diet (HFD) and further to elucidate possible mechanisms. Male C57BL/6J mice fed HFD were given T17 (2–4 × 108 cfu) intragastrically for 10 weeks. The results showed that the administration of T17 significantly suppressed HFD-induced body weight gain, alleviated HFD-induced increase in serum lipids and decreased energy intake. The serum levels of obesity-related metabolic signaling molecules, including insulin, adiponectin, lipopolysaccharide (LPS) and the cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α, were markedly improved. The 16S rRNA gene sequencing revealed that T17 administration dramatically modulated the gut microbiota, suppressing pathogenic and pro-inflammatory microbes and stimulating the microbes favoring anti-obesity. The weight-reducing efficacy of T17 may be explained by its ability to ameliorate systemic inflammation and insulin resistance mediated by gut microbiota. This study revealed that T17 could ameliorate obesity and the concomitant metabolic syndrome in mice and that the lactic acid bacteria in the sourdough ecosystem may also possess anti-obesity/weight-reducing properties.

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

“…Obesity and hyperglycemia induced by an HFD were closely associated with the gut microbiota dysbiosis, which has been confirmed in this study. In addition, recent researches have also demonstrated that probiotics intervention exhibited promising roles, such as antiobesity and insulin sensitivity by restoring the balance of the intestine microorganisms in murine models (24,33). In this study, B2 intervention decreased the α-diversity in comparison with the HFD group, indicating that B2 characteristically altered the gut bacterial community.…”

“…Lactobacillus plantarum ZJUFB2 (stored at China center for type culture collection, CCTCC M2020126) was screened from Chinese traditional fermented food (sourdough). The B2 tested sample was manufactured according to the reported guidelines (24). The concentration of the lyophilized B2 sample was ∼10 11 colony forming units per gram (CFU/g).…”

Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

“…This probiotic strain was isolated from healthy elderly subjects, with a high capacity to adhere to the intestinal mucosa, confirming excellent gut colonization that promotes a high probiotic properties expression [ 51 , 52 ]. The choice of this probiotic, together with the selection of the CAF diet, represent a novel approach in the source of this probiotic strain compared to those used in the already published papers, in which the Lactobacilli have food origins or similar (sourdough, such as in [ 53 ]). The human origin gave also better chances in expressing beneficial effects in humans.…”

Synbiotic (Lactiplantibacillus pentosus GSSK2 and isomalto-oligosaccharides) supplementation modulates pathophysiology and gut dysbiosis in experimental metabolic syndrome

“…Increased body weight is an important hallmark of metabolic syndrome and is accompanied by fat mass deposition. Interestingly, synbiotic + HFD animals had improved adiposity parameters with no change in average feed intake which might be attributed to lipoprotein lipase inhibition and release of appetite-reducing hormones glucagon-like peptide-1 and peptide YY either by probiotic or its metabolites resulting into increased energy expenditure, reduced visceral adipose tissue deposits and decreased mean adipocyte size 17 – 19 . Esposito et al 20 have also observed that supplementation of VSL#3 to HFD rats reduced fat mass with equal food intake.…”