Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death

LaLone, Carlie A.; Villeneuve, Daniel L.; Wu‐Smart, Judy; Milsk, Rebecca Y.; Sappington, Keith; Garber, K.; Housenger, justin; Ankley, Gerald T.

doi:10.1016/j.scitotenv.2017.01.113

Cited by 50 publications

(55 citation statements)

References 208 publications

(314 reference statements)

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“…There are multiple factors that contribute to bee decline, alone or in combination, such as habitat loss, pests, pathogens, and pesticide exposure (Kremen et al 2002, vanEngelsdorp et al 2009, Potts et al 2010, Bartomeus et al 2013). Neonicotinoid insecticides, pervasively used in agricultural and urban areas, have been debated as one contributor to global bee losses (Godfray et al 2014(Godfray et al , 2015van der Sluijs et al 2015;Goulson 2015;Lundin et al 2015;LaLone et al 2017). Neonicotinoids are systemic and may translocate throughout the plant including the nectar and pollen where foraging bees may become unintentionally exposed.…”

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confidence: 99%

Effects of neonicotinoid imidacloprid exposure on bumble bee (Hymenoptera: Apidae) queen survival and nest initiation

Wu‐Smart

Spivak

2017

Environmental Entomology

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Neonicotinoids are highly toxic to insects and may systemically translocate to nectar and pollen of plants where foraging bees may become exposed. Exposure to neonicotinoids can induce detrimental sublethal effects on individual and colonies of bees and may have long-term impacts, such as impaired foraging, reduced longevity, and reduced brood care or production. Less well-studied are the potential effects on queen bumble bees that may become exposed while foraging in the spring during colony initiation. This study assessed queen survival and nest founding in caged bumble bees [Bombus impatiens (Cresson) (Hymenoptera: Apidae)] after chronic (18-d) dietary exposure of imidacloprid in syrup (1, 5, 10, and 25 ppb) and pollen (0.3, 1.7, 3.3, and 8.3 ppb), paired respectively. Here we show some mortality in queens exposed at all doses even as low as 1 ppb, and, compared with untreated queens, significantly reduced survival of treated queens at the two highest doses. Queens that survived initial imidacloprid exposure commenced nest initiation; however, they exhibited dose-dependent delay in egg-laying and emergence of worker brood. Furthermore, imidacloprid treatment affected other parameters such as nest and queen weight. This study is the first to show direct impacts of imidacloprid at field-relevant levels on individual B. impatiens queen survival and nest founding, indicating that bumble bee queens are particularly sensitive to neonicotinoids when directly exposed. This study also helps focus pesticide risk mitigation efforts and highlights the importance of reducing exposure rates in the early spring when bumble bee queens, and other wild bees are foraging and initiating nests.

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confidence: 99%

Effects of neonicotinoid imidacloprid exposure on bumble bee (Hymenoptera: Apidae) queen survival and nest initiation

Wu‐Smart

Spivak

2017

Environmental Entomology

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“…One is that how to interpret subtle changes in behavior in terms of population demographics. The second is that neurobehavioral effects induced by pollutants are difficult for cross-species extrapolations [37,38]. Zebrafish larvae may become one potential model animal to come true embedding behavior into an AOP [39,40].…”

Section: Discussionmentioning

confidence: 99%

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

Zhang

Yin

et al. 2020

Environ Sci Eur

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Background: Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies of BDE-209 focused on the health effects and toxicity of thyroid disruption, oxidative stress, neurotoxicity, and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results: BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf ) larvae; however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concentration exposures. Conclusion:The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.

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“…Honeybees play a critical role as pollinators in many ecosystems (Potts et al ), and based on particular concerns for the health of honeybee colonies, one recent AOP network was constructed to organize information concerning chemical and nonchemical perturbations leading to honeybee colony failure (LaLone, Villaneuve et al ; AOP numbers 77–82 and numbers 84–90 at https://aopwiki.org/aops; Figure ), and to better understand potential factors affecting honeybee colony health. Thirteen AOPs in the honeybee AOP network begin with the MIE nicotinic acetylcholine receptor (nAChR) activation, with subsequent KEs leading to an AO of weakened colony performance and eventual colony failure (Figure ; LaLone, Villaneuve et al ). Although chemical stressors may contribute to declines in honeybee colonies, numerous other stressors are thought to influence honeybee colony health, including but not limited to pathogens and parasites, loss of habitat, and climate change (Potts et al ).…”

Section: Example Scenarios In Which Aops Can Inform Chemical Decisionmentioning

confidence: 99%

“…The nAChR AOPs for colony failure are described as putative, and the WoEs for the KERs vary from weak to strong (LaLone, Villaneuve et al ). If the AOP were to be applied to predict adverse effects in an ecological risk assessment scenario, then the KERs used to predict the AO would need to have a higher level of confidence.…”

Section: Example Scenarios In Which Aops Can Inform Chemical Decisionmentioning

confidence: 99%

When Are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision‐Making and Management of Chemicals?

Coady

Browne

Embry

et al. 2019

Integr Envir Assess & Manag

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There have been increasing demands for chemical hazard and risk assessments in recent years. Chemical companies have expanded internal product stewardship initiatives, and jurisdictions have increased the regulatory requirements for the manufacture and sale of chemicals. There has also been a shift in chemical toxicity evaluations within the same time frame, with new methodologies being developed to improve chemical safety assessments for both human health and the environment. With increased needs for chemical assessments coupled with more diverse data streams from new technologies, regulators and others tasked with chemical management activities are faced with increasing workloads and more diverse types of data to consider. The Adverse Outcome Pathway (AOP) framework can be applied in different scenarios to integrate data and guide chemical assessment and management activities. In this paper, scenarios of how AOPs can be used to guide chemical management decisions during research and development, chemical registration, and subsequent regulatory activities such as prioritization and risk assessment are considered. Furthermore, specific criteria (e.g., the type and level of AOP complexity, confidence in the AOP, as well as external review and assay validation) are proposed to examine whether AOPs and associated tools are fit for purpose when applied in different contexts. Certain toxicity pathways are recommended as priority areas for AOP research and development, and the continued use of AOPs and defined approaches in regulatory activities are recommended. Furthermore, a call for increased outreach, education, and enhanced use of AOP databases is proposed to increase their utility in chemicals management. Integr Environ Assess Manag 2019;15:633–647. © 2019 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

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Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death

Cited by 50 publications

References 208 publications

Effects of neonicotinoid imidacloprid exposure on bumble bee (Hymenoptera: Apidae) queen survival and nest initiation

Effects of neonicotinoid imidacloprid exposure on bumble bee (Hymenoptera: Apidae) queen survival and nest initiation

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

When Are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision‐Making and Management of Chemicals?

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