Weight Loss Associated with Bariatric Surgery Does Not Restore Short Telomere Length of Severe Obese Patients After 1 Year

Formichi, Caterina; Cantara, Silvia; Ciuoli, Cristina; Neri, Ornella; Chiofalo, Francesco; Selmi, Federico; Tirone, Andrea; Colasanto, Giuseppina; Cosmo, L. Di; Vuolo, Giuseppe; Pacini, Furio

doi:10.1007/s11695-014-1300-4

Cited by 24 publications

(31 citation statements)

References 30 publications

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“…Of these, one study found a positive relationship, in women with systemic lupus erythematosus . The other 38 studies found an inverse relationship . Among these articles, BMI was the most used method to assess obesity; only one study used WC and the adipocytes diameter as a main outcome variable instead of BMI.…”

Section: Resultsmentioning

confidence: 99%

Effect of obesity on telomere length: Systematic review and meta-analysis

Mundstock

Sarria

Zatti

et al. 2015

Obesity

172

146

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Objective: The main objective of this systematic review is to assess the effects of obesity on telomere length. Methods: The following databases were searched: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), LILACS, SPORTdiscus, and Web of Science from inception to August 2014. The search was performed using the following combinations of terms: telomere AND "overweight" OR "obesity" OR "adiposity," without language restriction. Results: Sixty-three original studies were included in this systematic review, comprising 119,439 subjects. Thirty-nine studies showed either weak or moderate correlation between obesity and telomere length; however, they showed an important heterogeneity. Conclusions: There is a tendency toward demonstrating negative correlation between obesity and telomere length. The selected studies showed weak to moderate correlation for the main search, and there was an important heterogeneity. For this reason, the causal relationship of obesity and telomere length remains open. Additional controlled longitudinal studies are needed to investigate this issue.

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Section: Resultsmentioning

confidence: 99%

Effect of obesity on telomere length: Systematic review and meta-analysis

Mundstock

Sarria

Zatti

et al. 2015

Obesity

172

146

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“…Corroborating the former, restored telomere length among overweight and obese individuals has been suggested following specific weight loss interventions, including bariatric surgery [33] and bioenteric intragastric balloon (BIB) in adults [34], and lifestyle modification in adolescents [35]. Nevertheless, a positive association between weight loss and LTL was observed among BIB but not bariatric surgery patients [33, 34, 36] and no alteration of telomere length was observed following lifestyle modification in adults [37, 38]. Except one study which followed the participants until 10 years after undergoing bariatric surgery [33], these previous findings had relatively short-term follow-up (6 months to 4.5 years), which may have limited the sensitivity in observing changes secondary to weight loss.…”

Section: Discussionmentioning

confidence: 99%

Investigating the associations between adiposity, life course overweight trajectories, and telomere length

Wulaningsih

Watkins²,

Matsuguchi

et al. 2016

Aging

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Obesity may accelerate ageing through chronic inflammation. To further examine this association, we assessed current adiposity, adiposity at early adulthood and life course overweight trajectories in relation to leukocyte telomere length (LTL). We included a total of 7,008 nationally representative U.S. residents and collected information on objectively measured body mass index (BMI), waist circumference and percent body fat. BMI at age 25 and overweight trajectories were assessed using self-reported history. Leukocyte telomere length (LTL) relative to a standard DNA reference (T/S ratio) was quantified by polymerase chain reaction (PCR). Linear regression models were used to examine the difference in LTL across adiposity measures at examination, BMI at age 25, and overweight trajectories. A 0.2% decrease in telomere length (95% CI:−0.3 to −0.07%) was observed for every kg/m2 increase in BMI, whereas a unit increase in waist circumference (cm) and percent body fat contributed to a 0.09% and 0.01% decrease in LTL, respectively. Higher BMI and being obese at age 25 contributed to lower LTL at older ages. Associations between weight loss through life course and LTL were observed, which further marked the importance of life course adiposity dynamics as a determinant of ageing.

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“…However, they also saw significant methodological, clinical, and statistical heterogeneity between studies, which suggests that this association needs to be better defined and additional causative factors must be taken into account [59]. The effect of intentional weight loss on telomere length has been studied in two RCTs and two non-randomized intervention studies (table 3) [8,9,60,61]. …”

Section: Resultsmentioning

confidence: 99%

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

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Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

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Weight Loss Associated with Bariatric Surgery Does Not Restore Short Telomere Length of Severe Obese Patients After 1 Year

Abstract: These results confirm that obese subjects have shorter telomeres compared to non-obese subjects, but RTL is not influenced by the presence of metabolic syndrome. RTL shows an additional attrition during the immediate post-operative period, probably due to a catabolic state.

Cited by 24 publications

References 30 publications

Effect of obesity on telomere length: Systematic review and meta-analysis

Effect of obesity on telomere length: Systematic review and meta-analysis

Investigating the associations between adiposity, life course overweight trajectories, and telomere length

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

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