2016
DOI: 10.18632/aging.101036
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Abstract: Obesity may accelerate ageing through chronic inflammation. To further examine this association, we assessed current adiposity, adiposity at early adulthood and life course overweight trajectories in relation to leukocyte telomere length (LTL). We included a total of 7,008 nationally representative U.S. residents and collected information on objectively measured body mass index (BMI), waist circumference and percent body fat. BMI at age 25 and overweight trajectories were assessed using self-reported history. … Show more

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Cited by 20 publications
(14 citation statements)
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References 50 publications
(56 reference statements)
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“…These results may indicate "a possible central role" of body adipos-ity in biomolecular markers of aging and that age per se (chronological age only) may not predict TL in master athletes, unlike apparently healthy non-athletes or diabetic adults [1,35]. Some studies have indicated that obese individuals have a chronic low degree of systemic inflammation [25], which is associated with an increased immune cell division [26,31] and thus leads to increased telomeric shortening [26,34]. So, as a practical point of view, keeping the % of body fat within optimal values (around 15 % for males and 23 % for females) may be an interesting anti-aging strategy.…”
Section: Non-athletes (N = 10)mentioning
confidence: 99%
“…These results may indicate "a possible central role" of body adipos-ity in biomolecular markers of aging and that age per se (chronological age only) may not predict TL in master athletes, unlike apparently healthy non-athletes or diabetic adults [1,35]. Some studies have indicated that obese individuals have a chronic low degree of systemic inflammation [25], which is associated with an increased immune cell division [26,31] and thus leads to increased telomeric shortening [26,34]. So, as a practical point of view, keeping the % of body fat within optimal values (around 15 % for males and 23 % for females) may be an interesting anti-aging strategy.…”
Section: Non-athletes (N = 10)mentioning
confidence: 99%
“…Genetic variation and sex have an additional influence on accelerated leukocyte telomere shortening. 76 Furthermore, substantial evidence has demonstrated that telomere shortening has been linked with greater risk of obesity 77 and cardiovascular disease. 78 In particular, a cohort study conducted on 7,008 U.S. residents suggested that a unit increase in percent body fat, waist circumference (cm) and body mass index (kg/m2) contributed, respectively, to a 0.01%, 0.09% and 0.2% decrease in leukocyte telomere length (T/S ratio), indicating that life course adiposity dynamics are the determinant of telomere shortening.…”
Section: Potential Role Of Rap1 In Diabetic Cardiomyopathymentioning
confidence: 99%
“… 78 In particular, a cohort study conducted on 7,008 U.S. residents suggested that a unit increase in percent body fat, waist circumference (cm) and body mass index (kg/m2) contributed, respectively, to a 0.01%, 0.09% and 0.2% decrease in leukocyte telomere length (T/S ratio), indicating that life course adiposity dynamics are the determinant of telomere shortening. 77 Also, the Strong Heart Family Study sheds light on the potential role of leukocyte telomere length in the prediction of adverse cardiovascular disease outcomes. 78 It was observed that longer leukocyte telomere length was significantly linked with reduced arterial stiffness.…”
Section: Potential Role Of Rap1 In Diabetic Cardiomyopathymentioning
confidence: 99%
“…In fact, obesity and metabolic syndrome promote biological aging and are associated with shorter PBL telomeres (Révész et al, ). Increased abdominal adiposity was found to be associated with accelerated PBL telomere attrition (Wulaningsih et al, ). Shorter PBL telomeres may indicate a premature aging condition which enhances chondrocyte senescence.…”
Section: Resultsmentioning
confidence: 99%