Weight loss and improved quality of life with a nonsurgical endoscopic treatment for obesity: clinical results from a 3- and 6-month study

Marinos, George; Eliades, Chris; Muthusamy, V. Raman; Greenway, Frank L.

doi:10.1016/j.soard.2014.03.005

Cited by 89 publications

(45 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It consists of a large spherical bulb connected to a small cylindrical bulb by a flexible catheter, which allows the device to position itself with the aid of peristaltic activity across the pylorus. In a prospective study of 20 patients with a mean BMI of 36 kg/m 2 , there was a mean %EWL of 41% at 6 months [31]. Patient tolerability was excellent without nausea or vomiting though 15 of 20 patients had mucosal erosions identified on scheduled endoscopy.…”

Section: Transpyloric Shuttlementioning

confidence: 99%

Primary endoscopic therapies for obesity and metabolic diseases

Kumbhari

Oberbach

Nimgaonkar³

2015

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

show abstract

Section: Transpyloric Shuttlementioning

confidence: 99%

Primary endoscopic therapies for obesity and metabolic diseases

Kumbhari

Oberbach

Nimgaonkar³

2015

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

show abstract

“…It is associated with nausea, vomiting, pain, and GERD, especially in the first 30 days after deployment. 52 …”

Section: Novel Devices Proposed In Obesity Treatment and Their Potentmentioning

confidence: 99%

Gastrointestinal traits: individualizing therapy for obesity with drugs and devices

Camilleri

Acosta

2016

Gastrointestinal Endoscopy

View full text Add to dashboard Cite

Objectives The objectives were to review the discrepancy between numbers of people requiring weight loss treatment and results, and to assess the potential effects of pharmacological treatments (recently approved for obesity) and endoscopically deployed devices on quantitative gastrointestinal traits in development for obesity treatment. Methods We conducted a review of relevant literature to achieve our objectives. Results The 2013 guidelines increased the number of adults recommended for weight loss treatment by 20.9% (116.0 million to 140.2 million). There is an imbalance between efficacy and costs of commercial weight loss programs and drug therapy (average weight loss ~5 kg). The number of bariatric procedures performed in the United States has doubled in the past decade. The efficacy of bariatric surgery is attributed to reduction in the volume of the stomach, nutrient malabsorption with some types of surgery, increased postprandial incretin responses, and activation of farnesoid X receptor mechanisms. These gastrointestinal and behavioral traits identify sub-phenotypes of obesity based on recent research. Conclusions The mechanisms or traits targeted by drug and device treatments include centrally mediated alterations of appetite or satiation, diversion of nutrients, and alteration of stomach capacity, gastric emptying, or incretin hormones. Future treatment may be individualized based on quantitative gastrointestinal and behavioral traits measured in obese patients.

show abstract

“…It reported a significant reduction in the effectiveness of the second consecutive balloon and no weight loss effect from subsequent balloon placements [15]. After removal of the first balloon (n ¼ 19), %EWL (mean, interquartile ratio [IQR]) was 49 , and TWL (mean, IQR in kilograms) was 15 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) kg. After removal of the second balloon, %EWL dropped to 18 (2.4-42) and TWL to 9.0 (1.0-13) kg.…”

Section: Space-occupying Devicesmentioning

confidence: 99%

“…The smaller sphere enters the duodenal bulb with peristalsis, which pulls the larger sphere to the pylorus and intermittently occludes the pylorus, delaying gastric emptying. One trial enrolled 20 patients and reported a 6-month (n = 10) mean Ϯ SD % EWL of 41 Ϯ 21 and %TWL of 14.5 Ϯ 5.8, with 2 patients requiring early removal due to persistent ulcer [23].…”

Section: Space-occupying Devicesmentioning

confidence: 99%