Weight, Length, and Body Mass Index Growth of Children under 2 Years of Age with Cleft Lip and Palate

Miranda, Gabriela Serrano; Marques, Inara; Barros, Suely Prietto de; Arena, Eliane Petean; Souza, Luiz de

doi:10.1597/14-003

Cited by 30 publications

(44 citation statements)

References 21 publications

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“…Malnutrition is a characteristic feature of CL/P (6,7). The growth pattern of the majority of patients with CL/P appears to be markedly abnormal, while some patients still follow a relatively normal pattern of weight and length acquisition (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the majority of our understanding of malnutrition and developmental delay in infants with CL/P has been acquired over the past 10 years (8)(9)(10)(11). Very little novel statistical data regarding the true development status of infants with CL/P has been published, with the exception of the studies from and Prahl et al (12) and Miranda et al (7). There is an urgent need for a large case statistical investigation of malnutrition and developmental delay in infants with CL/P in other districts and nations, especially in China.…”

Section: Introductionmentioning

confidence: 99%

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Physical Growth Status and Feeding Methods of Chinese Infants With Cleft Lip With or Without Cleft Palate Under 1 Year of Age

Sun

Liu

et al. 2020

Front. Pediatr.

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Objectives: Malnutrition is a characteristic feature of cleft lip with or without palate (CL/P). This study aims to retrospectively quantify the physical growth status, evaluate the feeding methods, and identify the possible correlation of CL/P types with growth failure.Methods: The length and weight of 508 infants with CL/P and 118 healthy infants were recorded at the date of admission. The weight-for-age (W/A), length-for-age (L/A), and body mass index-for-age (BMI) of the infants were calculated.Results: The L/A values were significantly lower in the infants with cleft lip (CL, 123 cases) and cleft lip with palate (CLP, 122 cases) than those of the control infants (p < 0.01). The W/A values of the infants with CP (263 cases) and CLP were significantly lower than those of the control infants (p < 0.05). However, the BMI index was not significantly different between any of the studied groups and the controls. In the mixed feeding group, the infants with CL and CP showed significantly lower L/A (p < 0.05) and W/A (p < 0.05), respectively.Conclusion: Physical growth issues were more common in the infants with CP and CLP. Because this was a retrospective study, the foods supplied to the patients were not strictly uniform, therefore, a prospective study with unified food supplement may be needed to confirm these findings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical Growth Status and Feeding Methods of Chinese Infants With Cleft Lip With or Without Cleft Palate Under 1 Year of Age

Sun

Liu

et al. 2020

Front. Pediatr.

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“…At the time of primary palate surgery, prevalence of FTT was 20% in ICP infants but had increased from 14% to 23% in UCLP infants and slightly decreased from 28% to 22% in BCLP infants. FTT prevalence was higher in syndromic than non-syndromic cleft infants (33% and 5% in syndomic and non-syndromic ICP infants respectively at the time of lip surgery) Miranda et al (2016). andTabari et al (2015) reported that 4.1% and 5% respectively of cleft palate with or without cleft lip infants had weight-for-age values above the 95 th percentile, suggesting that some CP±L children could be overweight.…”

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confidence: 98%

“…Miranda et al, 2016;Cubitt et al, 2012). The severity of undernutition in cleft infants is linked to the cleft type and the occurrence of other anomalies or syndromes with CLP and ICP infants being more undernourished compared to ICL infants(Miranda et al, 2016;Cubitt et al, 2012;Beaumont et al, 2008;Montagnoli et al, 2005)…”

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confidence: 99%

“…al., 2016; Da Silva Freitas et al, 2012; Reid, 2004; Avedian and Ruberg, 1980).Although CP±L children have more impaired BMI and weight-for-age growth compared to their ICL counterparts, the former experience a 'catch-up' growth, even without palatoplasty, beginning from the 9 th month to the 13 th month by which time the growth of the two groups are similar and close to the growth of normal children(Miranda et al, 2016;Da Silva Freitas et al, 2012) and this presents the possibility of affected children achieving adequate nutritional status when properly stimulated and supported Miranda et al (2016). surmised that it could be a case of CP±L infants getting adapted to their anomaly with time.…”

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confidence: 99%

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Malnutrition in Children With Unrepaired Orofacial Cleft: A Systematic Review

Nyakotey

Apprey

Annan

2019

IJPHCS

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Background:The anatomical defect of the oral cavity in children with orofacial clefts presents them with feeding challenges which increase their risk of becoming malnourished. The objective of this review was to investigate the extent of malnutrition among children under 5 years with unrepaired cleft of the lip and/ or palate. Materials and Methods:A systematic literature search of published articles that assessed malnutrition in children with unrepaired cleft lip and/or palate was conducted. Pubmed Central, Cochrane library, Pubmed (MEDLINE) and Google Scholar databases were searched.Result: A total of 4,489 papers were found of which 8 were included in the review after meeting the inclusion criteria. Malnutrition was found to be higher in isolated cleft palate and cleft lip and palate infants than in isolated cleft lip infants who had nutritional status close to that of non-cleft infants. Syndromic cleft infants were highly malnourished compared to nonsyndromic infants. Weight-for-age was the most assessed anthropometric indicator of nutritional status. Average prevalence of underweight (low weight-for-age) was 21.5%. Conclusion:Malnutrition is high especially within the first year of life in infants with unrepaired cleft lip and/or palate.

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Extraintestinal manifestations of celiac disease: 33‐mer gliadin binding to glutamate receptor GRINA as a new explanation

García-Quintanilla

Miranzo-Navarro

2016

BioEssays

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We propose a biochemical mechanism for celiac disease and non-celiac gluten sensitivity that may rationalize many of the extradigestive disorders not explained by the current immunogenetic model. Our hypothesis is based on the homology between the 33-mer gliadin peptide and a component of the NMDA glutamate receptor ion channel - the human GRINA protein - using BLASTP software. Based on this homology the 33-mer may act as a natural antagonist interfering with the normal interactions of GRINA and its partners. The theory is supported by numerous independent data from the literature, and provides a mechanistic link with otherwise unrelated disorders, such as cleft lip and palate, thyroid dysfunction, restless legs syndrome, depression, ataxia, hearing loss, fibromyalgia, dermatitis herpetiformis, schizophrenia, toxoplasmosis, anemia, osteopenia, Fabry disease, Barret's adenocarcinoma, neuroblastoma, urinary incontinence, recurrent miscarriage, cardiac anomalies, reduced risk of breast cancer, stiff person syndrome, etc. The hypothesis also anticipates better animal models, and has the potential to open new avenues of research.

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Weight, Length, and Body Mass Index Growth of Children under 2 Years of Age with Cleft Lip and Palate

Abstract: Children with CLP/ICP had impaired W/A and BMI growth with spontaneous recovery starting early in childhood. This study established specific W/A, BMI, and L/A growth curves for children with cleft lip and palate.

Cited by 30 publications

References 21 publications

Physical Growth Status and Feeding Methods of Chinese Infants With Cleft Lip With or Without Cleft Palate Under 1 Year of Age

Physical Growth Status and Feeding Methods of Chinese Infants With Cleft Lip With or Without Cleft Palate Under 1 Year of Age

Malnutrition in Children With Unrepaired Orofacial Cleft: A Systematic Review

Extraintestinal manifestations of celiac disease: 33‐mer gliadin binding to glutamate receptor GRINA as a new explanation

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