Weight gain during the treatment of thyrotoxicosis using conventional thyrostatic treatment

Rathi, Manish; Miles, Jeremy N. V.; Jennings, Paul

doi:10.1007/bf03346398

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…In the hyperthyroidism patients group, weight gain was observed on completion of treatment when the results of the thyroid function test returned to normal. This is a common finding in the literature13,15,20,21 and there are several theories regarding it. Hyperthyroidism induces an increased basal energy expenditure that leads to weight loss as a result of a decrease in the body’s lean and fat mass.…”

Section: Discussionmentioning

confidence: 69%

<p>Relationship between thyroid dysfunction and body weight: a not so evident paradigm</p>

Ríos-Prego¹,

Anibarro²,

Sánchez-Sobrino³

2019

IJGM

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PurposeHypothyroidism has traditionally been associated with obesity, whereas hyperthyroidism has been linked to being underweight. However, very few studies have assessed these associations. The aim of this work is to evaluate the association between thyroid dysfunction and body mass index (BMI) at baseline and after normalization of the hormone levels.Patients and methodsA retrospective, observational study of a cohort of otherwise healthy patients that were referred for evaluation of thyroid dysfunction to the Endocrine Department of Pontevedra University Complex Hospital, Spain was conducted. We collected data of BMI and thyroid hormone levels before treatment and after normalization of thyroid function within a follow-up period of 12 months.ResultsA total of 330 patients were initially selected for the study. In order to exclude variables that for any reason could influence on BMI, 235 were excluded for further studies. Another 61 patients were also excluded because incomplete data on their medical records, failure to achieve euthyroidism, or lost to follow-up. Therefore, the eligible final study group consisted of 34 patients (17 with hypothyroidism and 17 with hyperthyroidism). No differences were observed in mean baseline BMI between hypo and hyperthyroid patients (27.07±3.22 vs 26.39±4.44, p=0.609). Overweight or obesity was observed in 76.5% and 58.8% of hypothyroid and hyperthyroid patients, respectively (p=0.23). After normalization of thyroid function, the weight of hypothyroid patients decreased from 70.93±10.06 kg to 68.68±10.14 (p=0.000), while the weight of hyperthyroid patients increased from 65.45±11.64 kg to 68.37±12.80 (p=0.000). Their mean BMI was 26.22±3.36 and 27.57±4.98 (p=0.361) for hypo- and hyperthyroid patients, respectively. 58.8% and 64.7% patients remained in the overweight/obesity range in each group (p=0.72).ConclusionUntreated thyroid dysfunction is not associated with BMI. Normalization of thyroid levels significantly changed the weight of patients, but remaining most patients within overweight ranges.

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Section: Discussionmentioning

confidence: 69%

<p>Relationship between thyroid dysfunction and body weight: a not so evident paradigm</p>

Ríos-Prego¹,

Anibarro²,

Sánchez-Sobrino³

2019

IJGM

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“…Another commonly reported and strongly correlated risk factor is pre‐existing obesity; it is possible that hyperthyroidism and its reversal with treatment exacerbate or unmask the predisposition that some people have towards excessive weight accumulation. Excessive weight gain in the context of post‐RAI period has also been reported among those who stopped smoking, regardless whether the cessation was prior to or after RAI administration, whereas non‐smoking (vs smoking) status was found to be an independent risk factor for weight gain in a study which assessed patients with hyperthyroidism treated with ATDs …”

Section: Weight Changes Due To Hyperthyroidismmentioning

confidence: 92%

“…In a prospective controlled study 43 patients with Graves' disease had weight gain of 3.2 kg at 3‐4 months after treatment with ATDs . A retrospective study with 60 consecutive patients treated with ATDs for thyrotoxicosis was conducted with the main aim of determining whether weight gain persisted during euthyroidism (patients with transient hypothyroidism were excluded); average BMI at presentation was in the overweight range (26 kg/m 2 ), which is reflective of the background population in western countries nowadays. Average weight gain from presentation to establishment of euthyroidism was 3.9 kg and thereafter patients continued to gain an average of 2 kg in weight by 3 months which was maintained at 6 and 9 months whilst euthyroid.…”

Section: Weight Changes Due To Hyperthyroidismmentioning

confidence: 99%

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Weight gain following treatment of hyperthyroidism—A forgotten tale

Kyriacou

Makris

et al. 2019

Clinical Obesity

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Summary Hyperthyroidism causes weight loss in the majority, but its effect is variable and 10% of patients gain weight. Its treatment usually leads to weight gain and some studies have reported an excess weight regain. However, there is considerable inter‐individual variability and a differential effect on body weight by different treatments, with some studies reporting more weight increase with radioiodine, and perhaps surgery, compared with anti‐thyroid drugs. The excess weight regain may relate to treatment‐induced hypothyroidism. Furthermore, the transition from hyperthyroidism to euthyroidism may unmask, or exacerbate, the predisposition that some patients have towards obesity. Other risk factors commonly implicated for such weight increase include the severity of thyrotoxicosis at presentation and underlying Graves' disease. Conflicting data exist whether lean body mass or fat mass or both are increased post‐therapy and whether such increments occur concurrently or in a sequential manner; this merits clarification. In any case, clinicians need to counsel their patients regarding this issue at presentation. Limited data on the effect of dietary interventions on weight changes with treatment of hyperthyroidism are encouraging in that they cause significantly lesser weight gain compared to standard care. More research is indicated on the impact of the treatment of hyperthyroidism on various anthropometric indices and the predisposing factors for any excessive weight gain. Regarding the impact of dietary management or other weight loss interventions, there is a need for well‐designed and, ideally, controlled intervention studies.

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“…Previous studies have investigated the risk factors for excessive weight gain associated with hyperthyroidism treatments [ 4 , 5 , 17 , 18 ]. Many potential risk factors have been recognized, including hyperthyroidism treatment modality, male gender, ethnicity, severity of thyrotoxicosis at presentation, development of iatrogenic hypothyroidism post-treatment, cause of hyperthyroidism, and pre-existing obesity [ 4 , 5 , 17 , 18 ]. In our study, all patients were Chinese Han and were diagnosed with Graves' disease.…”

Section: Discussionmentioning

confidence: 99%

Weight Gain and Body Composition Changes during the Transition of Thyroid Function in Patients with Graves’ Disease Undergoing Radioiodine Treatment

Cai

Chen

Ling

2022

International Journal of Endocrinology

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Objective. This study aimed at investigating the dynamic changes in the body weight and body composition in a group of patients with Graves’ disease undergoing radioiodine therapy. Methods. Seventeen patients with Graves’ disease undergoing 131I treatment and forty-three euthyroid controls were recruited. Body weight, BMI, and body composition via bioelectrical impedance were measured for the participants at baseline, hypothyroid stage, and euthyroid stage. Results. Body weight increased significantly during the transition from hyperthyroidism to euthyroidism. However, there were no significant changes in body fat %, lean mass %, and bone mineral %. The body weight of 9 patients at the euthyroid stage exceeded their premorbid weight, while the remaining 8 patients’ weight did not exceed the premorbid weight. In the group with excessive weight gain, both body fat and lean mass increased significantly. However, in the group without excessive weight gain, only lean mass increased significantly. The patients with excessive weight gain had significantly higher body fat %, while lower lean mass % compared to patients without excessive weight gain at baseline and at the euthyroid stage. Moreover, body fat % of patients with excessive weight gain was significantly higher than that of controls, while lean mass % was significantly lower than that of controls. There was no difference of body fat % and lean mass % between patients without excessive weight gain and controls. Conclusion. 131I treatment caused significant weight gain in patients with Graves’ disease. An undesirable body composition at presentation may be a risk factor for excessive weight gain after hyperthyroidism treatment.

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Weight gain during the treatment of thyrotoxicosis using conventional thyrostatic treatment

Cited by 8 publications

References 11 publications

<p>Relationship between thyroid dysfunction and body weight: a not so evident paradigm</p>

<p>Relationship between thyroid dysfunction and body weight: a not so evident paradigm</p>

Weight gain following treatment of hyperthyroidism—A forgotten tale

Weight Gain and Body Composition Changes during the Transition of Thyroid Function in Patients with Graves’ Disease Undergoing Radioiodine Treatment

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