Weight gain after laparoscopic cholecystectomy

Ali, R; Ra, Chisei; Watson, R. G. K.

doi:10.1007/bf02914515

Cited by 17 publications

(10 citation statements)

References 13 publications

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“…Sonne et al ( 33 ) recently demonstrated a slight deterioration of postprandial glycemic control aft er GB removal, and even an increase in body weight has been reported in cholecystectomized patients ( 34 ). Moreover, and in line with current data from Ruhl and Everhard, recent studies in cholecystectomized mice have shown an increase in hepatic and serum TGs concentration, very-low-density lipoprotein synthesis and production, and BA pool cycling ( 35 ).…”

mentioning

confidence: 82%

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Nervi

Arrese

2013

American Journal of Gastroenterology

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Pathogenesis of nonalcoholic fatty liver (NAFLD) disease and gallbladder (GB) disease secondary to cholesterol gallstones is complex, yet both conditions share similar associated risk factors, most of them related to the metabolic syndrome. Cholecystectomy, the best treatment for GB disease, is one of the most performed abdominal surgeries worldwide. In this issue of the American Journal of Gastroenterology , Ruhl and Everhart, using data from the Third United States National Health and Nutrition Examination Survey (1988 -1994), show that NAFLD is associated with cholecystectomy (odds ratio (OR) = 2.4; 1.8 -3.3), but not with gallstones (OR = 1.1; 0.84 -1.4). This fi nding suggests that cholecystectomy may itself represent a risk factor for NAFLD, which is in line with the recently undisclosed role of the GB and bile acids in systemic metabolic regulation. Thus, cholecystectomy may not be innocuous and may have a major impact on public health by contributing to NAFLD development.

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confidence: 82%

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Nervi

Arrese

2013

American Journal of Gastroenterology

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“…Concordantly, experimental studies in mice have shown that XGB increases basal metabolic rate, serum and hepatic triglycerides concentration and very low-density lipoprotein (VLDL) production [28, 29]. Moreover, XGB has been associated with elevated VLDL levels [30], deteriorated postprandial glycemic control [31] and weight gain [32] in humans. The underlying mechanisms of these effects remain ill defined.…”

Section: Introductionmentioning

confidence: 99%

Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients: a pilot study

et al. 2017

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BackgroundNonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Experimental studies have shown that cholecystectomy (XGB) increases hepatic fat content in mice and appears associated to NAFLD in large retrospective population-based studies. The aim of this study was to prospectively assess the effects of XGB on hepatic fat content (HFC) and insulin resistance (IR) in non-obese, middle aged Hispanic subjects.MethodsTwenty-six gallstone patients undergoing elective XGB and 16 control subjects with normal livers and gallbladders at ultrasonography were prospectively followed 24 months for changes in HFC and IR. Clinical, biochemical determinations and hepatic imaging were performed at baseline and 24 months after surgery. MRI technique quantified HFC in four hepatic segments. IR was assessed by the Homeostasis Model Assessment (HOMA-IR) index.ResultsInitial body mass index (BMI) was 25.6 ± 0.4 and 24.3 ± 1.0 in the control and XGB groups of subjects, respectively. Serum insulin level increased from 8.1 ± 0.7 to 10.0 ± 1.9 (μU/ml) 24 months after surgery in XGB patients (p < 0.05); no significant changes were detected in control individuals. Median HOMA-IR index increased from 1.31 (interquartile range, 1.01-1.68) to 2.20 (interquartile range, 1.57 - 2.60) 24 months after XGB, (p < 0.003). Median HOMA-IR index of control subjects remained unchanged at the end of the study. Serum apoB concentration increased from 61.5 ± 3.4 to 79.0 ± 7.8 (μg/ml) in XGB patients (p < 0.03). Serum apoB levels remained within normal ranges in both periods of the study in control subjects. HFC significantly increased in 2 of the 4 segments 24 months after XGB: right posterior hepatic lobe (from 5.3 ± 0.2% to 6.0 ± 0.2%, p > 0.04) and right anterior hepatic lobe (from 5.8 ± 0.2% to 6.6 ± 0.3%, p < 0.02). The average HFC of the four hepatic segments studied slightly increased from 5.4 ± 0.2 to 5.8 ± 0.3 2 years after XGB (p < 0.03). No significant changes were found in HFC in the control subjects at the end of the study.ConclusionsElective XGB increases HFC, HOMA-IR index and serum apoB concentration. These results support the notion that XGB is a risk factor non-alcoholic fatty liver disease and other IR – associated disease conditions.

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“…The tendency for an increase in BMI after cholecystectomy was not seen in patients who had undergone nonbiliary surgery. 30 This weight gain was generally presumed to be caused by a return to the high-fat dietary habits that contributed to development of their cholelithiasis. 31 However, metabolic causes may have been a contributing factor, as there was no significant difference in weight gain between patients who remained on their preoperative low-fat diet and those who did not, with the former group showing an increase of 2 kg/m 2 in their mean BMI.…”

Section: Cholecystectomy and Mets Componentsmentioning

confidence: 99%

“…31 However, metabolic causes may have been a contributing factor, as there was no significant difference in weight gain between patients who remained on their preoperative low-fat diet and those who did not, with the former group showing an increase of 2 kg/m 2 in their mean BMI. 30 Obesity increases the likelihood of developing various diseases, including hypertension, coronary heart disease, fatty liver disease, and T2DM. Further increases in BMI can adversely affect the long term health of these patients, because many of them are overweight prior to surgery.…”

Section: Cholecystectomy and Mets Componentsmentioning

confidence: 99%

Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

Chen

Tian

2018

Laboratory Investigation

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Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.

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Weight gain after laparoscopic cholecystectomy

Abstract: Selection for LC may identify patients at risk of continuing or resumed aetiological contributors to obesity. Follow-up long after the surgery may therefore be necessary to facilitate additional healthcare interventions.

Cited by 17 publications

References 13 publications

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Editorial : Cholecystectomy and NAFLD: Does Gallbladder Removal Have Metabolic Consequences?

Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients: a pilot study

Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

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