Abstract:Objective: This study aimed to determine whether multiple weight cycles in adulthood are an independent predictor of lower muscle mass and reduced strength, with potential implication for sarcopenia in adults with obesity. Methods: A total of 60 males and 147 females with obesity were included, with a mean BMI of 37.9 ± 6.0 kg/m 2 and a mean age of 52.6 ± 12.4 years. Muscle strength was evaluated with handgrip and appendicular skeletal muscle mass was measured with dual-energy x-ray absorptiometry. Results: Pa… Show more
“…Natural history of sarcopenia coupled to obesity clearly needs to be further elucidated by future research. An important aspect concerning sarcopenic obesity is weight cycling and body composition trajectory [113] as it may induce repeated FFM loss which is not completely recovered during weight regain in relation to post-restriction metabolic and hormonal alterations during refeeding [114].…”
Section: ) Role Of Different Clinical Factors In the Pathogenesis Ofmentioning
Background: Sarcopenic obesity is a clinical and functional condition characterized by the coexistence of excess fat mass and sarcopenia. Currently, different definitions of sarcopenic obesity exist and its diagnostic criteria and cutoffs are not universally established. Therefore, the prevalence and sensitivity of this condition for any disease risk prediction is affected significantly. Aim: This work was conducted under the auspices of the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO). An international expert panel performed a systematic review as an initial step to analyze and summarize the available scientific literature on the definitions and the diagnostic criteria for sarcopenic obesity proposed and/or applied in human studies to date. Methods: The present systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The search was conducted in April 2018 in three databases (PubMed, Scopus, Web of Science). Human studies conducted in both sexes, irrespective of ethnicity, and published from 2007 to 2018 were included; cohorts of individuals with obesity and
“…Natural history of sarcopenia coupled to obesity clearly needs to be further elucidated by future research. An important aspect concerning sarcopenic obesity is weight cycling and body composition trajectory [113] as it may induce repeated FFM loss which is not completely recovered during weight regain in relation to post-restriction metabolic and hormonal alterations during refeeding [114].…”
Section: ) Role Of Different Clinical Factors In the Pathogenesis Ofmentioning
Background: Sarcopenic obesity is a clinical and functional condition characterized by the coexistence of excess fat mass and sarcopenia. Currently, different definitions of sarcopenic obesity exist and its diagnostic criteria and cutoffs are not universally established. Therefore, the prevalence and sensitivity of this condition for any disease risk prediction is affected significantly. Aim: This work was conducted under the auspices of the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO). An international expert panel performed a systematic review as an initial step to analyze and summarize the available scientific literature on the definitions and the diagnostic criteria for sarcopenic obesity proposed and/or applied in human studies to date. Methods: The present systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The search was conducted in April 2018 in three databases (PubMed, Scopus, Web of Science). Human studies conducted in both sexes, irrespective of ethnicity, and published from 2007 to 2018 were included; cohorts of individuals with obesity and
“…We examined the effects of resveratrol, a natural polyphenolic compound present in grapes, on sarcopenia obesity in (high-fat diet (HFD)-induced obesity mice and aging-associated sarcopenia SAMP8 mice. The resveratrol theory of aging provides reasonable explanations for ageassociated sarcopenica (38). In addition, studies strongly suggest that resveratrol play a significant role in the deterioration of skeletal muscle with obesity and sarcopenia with age-associated phenomena (39).…”
Running title: Resveratrol attenuates sarcopenic obesity.
Abstract words:243The maximum word count of the main text (including the main text and figure legends, but not the title page, abstract, materials and methods section or reference list): 4222
AbstractSarcopenic obesity is a progressive loss of skeletal muscle mass and strength with increases in adiposity. The aim of this study was to investigate the effects of resveratrol on obesity or sarcopenia to potential therapy risk for skeletal muscle declines in physical function. C57BL/6J male mice were fed either a high-fat diet for 4 weeks and resveratrol (low-, middle-, and high-dose) for 8 weeks to express the obesity effect. Samp8 mice sarcopenia skeletal muscle functional deterioration expressed an age-associated decline. Resveratrol (150 mg/Kg BW, daily) was administered by oral gavage two times a week one month of the experimental period. Exercise training based on adaptations in the muscle is training twice a week for 4 weeks. The skeletal muscles from mice in each group were analyzed by H&E staining, TUNEL and western blot analysis to determine mitochondrial function expression, apoptosis and relative fibrosis signaling. Results of the present study indicate that resveratrol in obesity skeletal muscle is linked to an increase in the expression of mitochondrial function involved in Bcl-2 and PI3K/AKT. On the other hand, resveratrol attenuates sarcopenia Samp8 mice, the age-related loss of skeletal muscle mass and mitochondrial function involved in Bad, caspase 3 and IL-6/ERK1. However, exercise training not find a significant difference in sarcopenia skeletal muscles SAMP8 mice. Exercise training didn't induce sarcopenia skeletal muscle hypertrophy in sarcopenic SAMP8 mice. Therefore, we suggest that resveratrol as a therapeutic potential in the combination of sarcopenia and obesity, the state called sarcopenic obesity.
“…A questionnaire was administered to participants in order to gather information regarding their social demographic (age, marital status, employment, level of education, etc.). Moreover, their prior intentional weight-loss attempts were carefully evaluated by a trained dietician involved in the study, and WC was deemed to be intentional weight loss of ≥3 kg, followed by involuntary weight regain of ≥3 kg [16]. Participants were considered multiple WC if they experienced ≥2 cycles [16].…”
Section: Methodsmentioning
confidence: 99%
“…This repeated failure in the long-term maintenance of weight loss leads to body weight fluctuation over time, termed 'weight cycling' (WC) [11]. In the last few decades, the study of this phenomenon has gained particular attention, and several pieces of research have attempted to clarify whether WC may adversely affect health outcomes [12][13][14][15][16]. However, such research has produced inconsistent evidence, especially in terms of changes in body composition patterns.…”
Weight cycling (WC) is a common phenomenon in patients with obesity, however, its consequence on body composition has not yet been fully understood. Therefore, we aimed to determine whether multiple WC can negatively affect the latter, especially in terms of body fat distribution in female adults seeking treatment that are overweight or obese. Body composition was obtained using a segmental body composition analyser (MC-780MA, Tanita Corp., Tokyo, Japan) in 125 adult females who had been referred to the Department of Nutrition and Dietetics at the Beirut Arab University (Lebanon). WC was defined as intentional weight loss of ≥3 kg followed by involuntary weight regain of ≥3 kg, and participants were categorized as WC if they had experienced ≥2 cycles. Ninety of the 125 participants met the criteria for WC and displayed a higher total and trunk fat mass than those without WC. This was confirmed through linear regression analysis, showing that multiple WC were associated with increased fat mass (FM) by nearly 4.2 kg (β = 4.23, 95%CI: 0.81–7.65, p = 0.016)–2.4 kg in the trunk region (β = 2.35, 95%CI: 0.786–3.917, p = 0.004) when compared to the non-WC group, after adjusting for age and fat-free mass. In conclusion, multiple WC is associated with increased body fat, especially in the central region. Future studies are needed to examine the impact of this fat distribution on health outcomes in this phenotype of patients.
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