In the past decades, with the increasing awareness of personal health management, various types of flexible and wearable body sensors have been developed. Thanks to the superiorities of advanced wearable technologies, including miniaturization and portability, stretchability and comfortability, intelligent human-machine interface, etc., flexible and wearable body sensors hold great promise in the next generation biomedicine and healthcare applications. Unfortunately, the data precision, response speed, sensitivity and selectivity, durability, compatibility with flexible substrates, and preparation technics still need to be enhanced and refined to meet the requirements of clinical evaluations or even commercialization. According to the working principles, flexible and wearable sensing platform can be roughly divided into four categories: physical sensors, chemical sensors, biosensors, and the fusion of different types of sensors. Here, a brief review focused on recent developments of these flexible and wearable sensors applied especially to biomedicine and healthcare is presented. In addition, the existing challenges and potential opportunities ahead in flexible and wearable sensor technologies are discussed. At last, an outlook of wearable sensing platforms in biomedicine and healthcare is proposed. We hope this review can provide guidance for superior flexible and wearable sensing technologies in the future.