Wearable Chemical Sensors: Emerging Systems for On-Body Analytical Chemistry

Sempionatto, Juliane R.; Jeerapan, Itthipon; Krishnan, Sadagopan; Wang, Joseph

doi:10.1021/acs.analchem.9b04668

Cited by 157 publications

(121 citation statements)

References 122 publications

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“…The wearable sensor has become a new concept of ion-selective devices [1,4,[6][7][8][9]74]. As proposed, biomedical diagnostics are experiencing a change from labor-based implements to portable devices.…”

Section: Wearable Sensorsmentioning

confidence: 99%

“…Conventional applications in medical biomarker detection generally related to separated collection and analysis of blood samples is invasive and costly and needs complicated operations, while failing to provide users with real-time health diagnostics and monitoring. Wearable sensors hold great promise for continuously monitoring an individual's physiological bio-chemical signals [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors

et al. 2020

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Wearable sensors based on solid-contact ion-selective electrodes (SC-ISEs) are currently attracting intensive attention in monitoring human health conditions through real-time and non-invasive analysis of ions in biological fluids. SC-ISEs have gone through a revolution with improvements in potential stability and reproducibility. The introduction of new transducing materials, the understanding of theoretical potentiometric responses, and wearable applications greatly facilitate SC-ISEs. We review recent advances in SC-ISEs including the response mechanism (redox capacitance and electric-double-layer capacitance mechanisms) and crucial solid transducer materials (conducting polymers, carbon and other nanomaterials) and applications in wearable sensors. At the end of the review we illustrate the existing challenges and prospects for future SC-ISEs. We expect this review to provide readers with a general picture of SC-ISEs and appeal to further establishing protocols for evaluating SC-ISEs and accelerating commercial wearable sensors for clinical diagnosis and family practice.

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Section: Wearable Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors

et al. 2020

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“…However, it is worth noting that many of these biosensors have additional features with great practical relevance. The important advances provided by wearable devices for real-time electrochemical biosensing have been extensively reviewed in the last few years [ 14 , 15 , 16 , 17 , 18 , 19 ] and are not discussed in this article.…”

Section: Continuous Real-time Electrochemical Biosensors: Towardsmentioning

confidence: 99%

Beyond Sensitive and Selective Electrochemical Biosensors: Towards Continuous, Real-Time, Antibiofouling and Calibration-Free Devices

Campuzano

Pedrero

Gamella

et al. 2020

Sensors

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Nowadays, electrochemical biosensors are reliable analytical tools to determine a broad range of molecular analytes because of their simplicity, affordable cost, and compatibility with multiplexed and point-of-care strategies. There is an increasing demand to improve their sensitivity and selectivity, but also to provide electrochemical biosensors with important attributes such as near real-time and continuous monitoring in complex or denaturing media, or in vivo with minimal intervention to make them even more attractive and suitable for getting into the real world. Modification of biosensors surfaces with antibiofouling reagents, smart coupling with nanomaterials, and the advances experienced by folded-based biosensors have endowed bioelectroanalytical platforms with one or more of such attributes. With this background in mind, this review aims to give an updated and general overview of these technologies as well as to discuss the remarkable achievements arising from the development of electrochemical biosensors free of reagents, washing, or calibration steps, and/or with antifouling properties and the ability to perform continuous, real-time, and even in vivo operation in nearly autonomous way. The challenges to be faced and the next features that these devices may offer to continue impacting in fields closely related with essential aspects of people’s safety and health are also commented upon.

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“…Nanomaterials have been utilized and demonstrated in wearable, portable, and miniaturized electrochemical sensors for many applications, ranging from quick diagnostic tools to modern healthcare and biomedical applications [17][18][19][20]. These open up exciting opportunities to realize immediate or continuous analytical detection of significant biomarkers or pathogens for out-of-clinic biomedical evaluation.…”

Section: Conclusion and Outlooksmentioning

confidence: 99%

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

2020

Self Cite

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Personal biosensors and bioelectronics have been demonstrated for use in out-of-clinic biomedical devices. Such modern devices have the potential to transform traditional clinical analysis into a new approach, allowing patients or users to screen their own health or warning of diseases. Researchers aim to explore the opportunities of easy-to-wear and easy-to-carry sensors that would empower users to detect biomarkers, electrolytes, or pathogens at home in a rapid and easy way. This mobility would open the door for early diagnosis and personalized healthcare management to a wide audience. In this review, we focus on the recent progress made in modern electrochemical sensors, which holds promising potential to support point-of-care technologies. Key original research articles covered in this review are mainly experimental reports published from 2018 to 2020. Strategies for the detection of metabolites, ions, and viruses are updated in this article. The relevant challenges and opportunities of applying nanomaterials to support the fabrication of new electrochemical biosensors are also discussed. Finally, perspectives regarding potential benefits and current challenges of the technology are included. The growing area of personal biosensors is expected to push their application closer to a new phase of biomedical advancement.

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Wearable Chemical Sensors: Emerging Systems for On-Body Analytical Chemistry

Cited by 157 publications

References 122 publications

Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors

Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors

Beyond Sensitive and Selective Electrochemical Biosensors: Towards Continuous, Real-Time, Antibiofouling and Calibration-Free Devices

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

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