We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

“…Compound-mediated proteasome activation may occur through induction of transcription factors that are responsible for the expression of various proteasome subunits or various proteasome regulators, through post-translational modifications of proteasome subunits and regulators or through direct effects on the proteasome conformation [ 53 , 54 ]. The identified compounds that fall into the last category (i.e., structural proteasome activators) are far fewer than those of the remaining categories, especially if we refer to natural compounds.…”

Deschampsia antarctica extract (Edafence®) as a powerful skin protection tool against the aging exposome

“…A rich source of substances and compounds is found in the natural world, because organisms have confronted environmental damaging agents such as ionizing radiations and toxins from the beginning of time, and the molecular damage mechanisms also apply to byproducts of endogenous metabolism. Thus, compounds with antioxidant and protective activities, also capable of boosting endogenous defense mechanisms, are found in nature and have been explored for their therapeutic potential since ancient times [69][70][71][72][73][74] .…”