WBSCR22 confers cell survival and predicts poor prognosis in glioma

Chi, Yajie; Liang, Zi; Guo, Yanwu; Chen, Daliang; Lu, Lenian; Lin, Jiye; Qiu, Shengcong; Wang, Xiang; Qiu, Erning; Lin, Fang; Chen, Jianmin; Luo, Shi; Zheng, Dahai; Xu, Xia

doi:10.1016/j.brainresbull.2020.04.024

Cited by 18 publications

(19 citation statements)

References 28 publications

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“…For example, METTL1 and WDR4 play a strong carcinogenic role in AML, BC, ESCC, glioma, HCC, HNSCC, ICC, LC, and NPC, promoting the malignant phenotype and progression of tumors [ 24 , 26 , 43 , 52 , 56 , 59 , 60 , 66 , 68 , 78 ]; however, METTL1 exerts a significant anti-cancer effect in CC [ 48 ]. WBCCR22 restrains PC development, while accelerating glioma progression [ 57 , 80 ]. These m7G regulators perform biological functions by affecting m7G modification of various RNAs.…”

Section: Discussionmentioning

confidence: 99%

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The potential role of N7-methylguanosine (m7G) in cancer

et al. 2022

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N7-methylguanosine (m7G), one of the most prevalent RNA modifications, has recently attracted significant attention. The m7G modification actively participates in biological and pathological functions by affecting the metabolism of various RNA molecules, including messenger RNA, ribosomal RNA, microRNA, and transfer RNA. Increasing evidence indicates a critical role for m7G in human disease development, especially cancer, and aberrant m7G levels are closely associated with tumorigenesis and progression via regulation of the expression of multiple oncogenes and tumor suppressor genes. Currently, the underlying molecular mechanisms of m7G modification in cancer are not comprehensively understood. Here, we review the current knowledge regarding the potential function of m7G modifications in cancer and discuss future m7G-related diagnostic and therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

“…METTL1 enhances the proliferation and growth of glioma, which may involve the tumor-related MAPK signaling pathway [ 56 ]. WBSCR22 is also upregulated in glioma and acts as an unfavorable survival predictor [ 57 ]. WBSCR22 enhances glioma cell growth and metastasis by regulating the PI3K/AKT/GSK3β signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

The potential role of N7-methylguanosine (m7G) in cancer

et al. 2022

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“…The human WBSCR22 protein has been identified as a methyltransferase for 18S rRNA m 7 G and is involved in pre-rRNA processing and 40S ribosome subunit biogenesis. The elevated expression levels and the tumor-promoting potential of WBSCR22 have been observed in several types of cancer (10)(11)(12)(13)(14)(15)(16)(17)(18). However, the role of WBSCR22 in PC remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…WBSCR22 has been reported as an oncogene in several carcinomas, including invasive breast cancer, multiple myeloma, plasma cell carcinoma, colorectal cancer, lung cancer and hepatocellular carcinoma (13)(14)(15)(16)(17). In glioma cells, upregulation of WBSCR22 promotes proliferation, invasion, tumorigenesis and migration, while its knockdown exerts the opposite effects (18). In contrast to these findings, WBSCR22 loss has also been reported in certain neoplastic and inflammatory types of human lung pathologies, which indicates that the role of WBSCR22 in different cancer types is tissue specific (16).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that WBSCR22 expression is upregulated in several types of cancer, including invasive breast cancer ( 13 ), multiple myeloma, plasma cells ( 14 ), colorectal cancer ( 15 ), lung cancer ( 16 ) and hepatocellular carcinoma ( 17 ). In addition, upregulation of WBSCR22 expression promotes invasion, proliferation and migration, while knockdown of this gene exhibits the opposite effects in glioma cells ( 18 ). WBSCR22 exhibits tumor-promoting potential in several types of cancer, whereas WBSCR22 loss has also been reported in specific inflammatory-type human lung pathologies ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15

et al. 2022

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Pancreatic cancer (PC) is one of the most aggressive and devastating types of cancer owing to its poor prognosis and deadly characteristics. It is well established that aberrations in the expression of key regulatory genes, namely tumor suppressors and oncogenes, predispose patients to progression and metastasis of PC. Upregulation of Williams-Beuren syndrome chromosomal region 22 (WBSCR22) expression, a ribosomal biogenesis factor, has been reported in multiple types of human cancer. However, the role of WBSCR22 and its underlying mechanism in PC have not been well investigated. In the present study, the tumor suppressive role of WBSCR22 was reported in PC for the first time; the results indicated that WBSCR22 overexpression (OE) significantly suppressed cellular proliferation, migration, invasion and tumorigenesis in vivo and in vitro. RNA-sequencing analysis revealed that WBSCR22 negatively regulated the transcription of interferon-stimulated gene 15 (ISG15) downstream, which is a ubiquitin-like modifier protein involved in metabolic and proteasome degradation pathways, while the antitumor function of WBSCR22-OE could be rescued by ISG15 OE. In addition, the oncogenic role of ISG15 was further confirmed in PC; its upregulation promoted the proliferation, migration, invasion and tumorigenesis of PC. Furthermore, WBSCR22 and its cofactor tRNA methyltransferase activator subunit 11-2 (TRMT112) functioned synergistically in PC, and concurrent ectopic OE of WBSCR22 and TRMT112 further promoted the tumor suppressive potential of WBSCR22 in PC. Collectively, the findings indicated that WBSCR22 played an important role in PC development and that the WBSCR22/ISG15 axis may provide a novel therapeutic strategy for PC treatment.

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Pan‐Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival

Su,

Song,

Wong

2024

Cancer Reports

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BackgroundN7‐methylguanosine (m7G) modification is one of the most prevalent RNA modifications in humans. Dysregulated m7G modifications caused by aberrant expression of m7G writers contribute to cancer progression and result in worse patient survival in several human cancers. However, studies that systematically assess the frequency and clinical relevance of aberrant m7G writer expression in a pan‐cancer cohort remain to be performed.AimsThis study aims to systematically investigate the molecular alteration and clinical relevance of m7G methyltransferase in human cancers.MethodsWe analysed genome, transcriptome and clinical data from the Cancer Genome Atlas Research Network spanning 33 types of human cancers for aberrant changes in genes encoding m7G writers.ResultWe demonstrate that m7G writers are dysregulated in human cancers and are associated predominantly with poorer survival. By dividing patients into those with high and low m7G scores, we show that a lower m7G score is generally associated with immune infiltration and better response to immunotherapy.ConclusionOur analyses indicate the genetic alterations, expression patterns and clinical relevance of m7G writers across various cancers. This study provides insights into the potential utility of m7G writer expression as a cancer biomarker and proposes the possibility of targeting m7G writers for cancer therapy.

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WBSCR22 confers cell survival and predicts poor prognosis in glioma

Cited by 18 publications

References 28 publications

The potential role of N7-methylguanosine (m7G) in cancer

The potential role of N7-methylguanosine (m7G) in cancer

WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15

Pan‐Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival

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WBSCR22 confers cell survival and predicts poor prognosis in glioma

Cited by 18 publications

References 28 publications

The potential role of N7-methylguanosine (m7G) in cancer

The potential role of N7-methylguanosine (m7G) in cancer

WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15

Pan‐Cancer Analysis Links Altered RNA m7G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival

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Pan‐Cancer Analysis Links Altered RNA m⁷G Methyltransferase Expression to Oncogenic Pathways, Immune Cell Infiltrations and Overall Survival