Wavelength‐Selective Light‐Induced Release from Plasmon Resonant Liposomes

Leung, Sarah J.; Kachur, Xenia M.; Bobnick, Michael C.; Romanowski, Marek

doi:10.1002/adfm.201002373

Cited by 67 publications

(87 citation statements)

References 64 publications

(61 reference statements)

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“…(DSPC:DPPC), or 80:20 (DPPC:Chol), were tethered with AuNPs up to 132 ng/mL for exploring the optimal photoresponsive liposome for the fiber-optic guided laser triggered release study. 17,26,27,[39][40][41][42] The 90:10:4 (DPPC:MPPC:DSPEPEG2k) liposome with 33 ng/mL AuNPs achieved the strongest photo-thermal conversion efficiency while maintaining decent liposome integrity at physiological temperature without causing significant leakage (21.92%±2.08% in 40 minutes without excitation) as shown in Figure 6. The AuNP-incorporated liposomes were spherical in shape with AuNPs appearing as black dots floating on the surface, and had a uniform particle size distribution, primarily around 100 nm, as observed by TEM ( Figure 4B).…”

Section: Photo-thermal Energy Conversion Efficiency Of Aunps In Vitromentioning

confidence: 89%

“…Because of their proven biocompatibility and efficient photo-thermal conversion through surface plasma resonance, AuNPs (cluster, nanoshell) have previously been deposited on the liposome membrane outer surface, tethered to the liposome membrane, or entrapped within the liposome cavity for remotely triggered content release through wavelength-specific light excitation from the ultraviolet to near infrared region. [39][40][41][42] However, no studies have reported their corresponding content release efficiencies triggered by light excitation in vivo. This may be due to challenges caused by the inconsistent results of in vivo non-invasive irradiation from varying subject/disease conditions (such as tumor size and location).…”

Section: Discussionmentioning

confidence: 99%

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Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy

Huang¹,

Lu²,

Yang³

et al. 2015

IJN

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The aim of this research is to provide proof of principle by applying the fiber-optic triggered release of photo-thermally responsive liposomes embedded with gold nanoparticles (AuNPs) using a 200 μm fiber with 65 mW and 532 nm excitation for topical release in vivo. The tunable delivery function can be paired with an apoptosis biosensor based on the same fiber-optic configuration for providing real-time evaluation of chemotherapy efficacy in vivo to perform as a personalized chemotherapy system. The pattern of topical release triggered by laser excitation conveyed through optical fibers was monitored by the increase in fluorescence resulting from the dilution of self-quenching (75 mM) fluorescein encapsulated in liposomes. In in vitro studies (in 37°C phosphate buffer saline), the AuNP-embedded liposomes showed a more efficient triggered release (74.53%±1.63% in 40 minutes) than traditional temperature-responsive liposomes without AuNPs (14.53%±3.17%) or AuNP-liposomes without excitation (21.92%±2.08%) by spectroscopic measurements. Using the mouse xenograft studies, we first demonstrated that the encapsulation of fluorescein in liposomes resulted in a more substantial content retention (81%) in the tumor than for free fluorophores (14%) at 120 minutes after administration from in vivo fluorescence imaging. Furthermore, the preliminary results also suggested the tunable release capability of the system by demonstrating consecutive triggered releases with fiber-optic guided laser excitation.

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Section: Photo-thermal Energy Conversion Efficiency Of Aunps In Vitromentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy

Huang¹,

Lu²,

Yang³

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…[8][9][10][11] While most of them focus on the novelty of materials, accessibility and scalability issues need to be addressed. Moreover, reports on release mechanisms using these nanocarriers are still limited.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Chan

Ohl

2016

JoVE

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Photo-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we describe a facile fabrication of these photo-responsive NPs with commercially available gold NPs and thermo-responsive liposomes. Calcein is used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone.

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“…Gold liposomes were developed by the reduction of gold chloride onto the 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposome surface following a previously reported method [21]. As shown in Table 1, gold liposomes showed a hydrodynamic size around 103 nm, and uncoated liposomes were around 92 nm.…”

Section: Preparation and Characterization Of Gold Liposomesmentioning

confidence: 99%

Overcoming Multidrug Resistance by On-Demand Intracellular Release of Doxorubicin and Verapamil

Jiang

Liu

Wang

et al. 2018

Journal of Nanomaterials

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Multidrug resistance (MDR) is one of the major obstacles to the successful application of cancer chemotherapy. Herein, we developed light-responsive doxorubicin-and-verapamil-coencapsulated gold liposomes to overcome MDR. Upon ns-pulsed laser irradiation, the highly confined thermal effect increased the permeability of the phospholipid bilayer, triggering the release of doxorubicin and verapamil, leading to high concentrations in cells. Free verapamil efficiently inhibited the membrane multidrug resistance proteins (MRPs), while the high concentration of doxorubicin saturated MRPs, thus overcoming MDR. We showed that nanosecond- (ns-) pulsed laser- (532 nm, 6 ns) induced doxorubicin release from gold liposomes depended on laser fluence and pulse number. More than 58% of the doxorubicin was released with a 10-pulse irradiation (100 mJ/cm2). Furthermore, ns laser pulses also liberated doxorubicin from endocytosed gold liposomes into the cytosol in MDA-MB-231-R cancer cells. The cytotoxicity of doxorubicin coencapsulated with verapamil was significantly enhanced upon laser irradiation. This study suggested that light-triggered on-demand release of chemotherapeutic agents and MRP inhibitors could be used advantageously to overcome multidrug resistance.

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Wavelength‐Selective Light‐Induced Release from Plasmon Resonant Liposomes

Cited by 67 publications

References 64 publications

Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy

Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Overcoming Multidrug Resistance by On-Demand Intracellular Release of Doxorubicin and Verapamil

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