Wavefront-guided epithelial laser in situ keratomileusis with mitomycin-C for myopia and myopic astigmatism: Flap-on versus flap-off technique

Ang, Robert Edward; Reyes, Karen B.; Hernandez, Jo Anne; Tchah, Hungwon

doi:10.1016/j.jcrs.2010.12.052

Cited by 11 publications

(23 citation statements)

References 19 publications

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“…Six RCTs and 3 comparative studies published between 2008 and 2011 met the inclusion criteria [7,8,9,13,14,15,16,17,18]. A total of 489 patients (958 eyes) underwent off-flap epi-LASIK and on-flap epi-LASIK.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 489 patients (958 eyes) underwent off-flap epi-LASIK and on-flap epi-LASIK. Patients’ mean age ranged from 20.25 to 33 years and the mean preoperative manifest spherical equivalent (MSE) ranged from –3.49 D to –9.14 D; 0.02% mitomycin C (MMC) was used for 15–120 s in 6 studies [9,13,14,16,17,18]. Each study revealed that there were no significant differences in preoperative demographic features and other factors that may have influenced surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported data for postoperative manifest refractive spherical equivalent [7,8,13,15,16,17,18]. Follow-up time ranged from 6 months to 1 year.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies reported data for the proportion of participants within ±0.50 D of target refraction [7,9,14,15,18]. The follow-up time ranged from 3 months to 1 year.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies reported the mean logMAR uncorrected visual acuity (UCVA) at 3 days postoperatively [7,8,9,18]. Significant heterogeneity was detected between study results (I 2 = 78%) and the random-effects meta-analysis was performed.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

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Objective: To examine possible differences in clinical outcomes between off-flap and on-flap epipolis laser in situ keratomileusis (epi-LASIK) for myopia. Methods: Pertinent studies were selected by extensive searches. A total of 9 studies reporting on a total of 958 eyes were included in the present meta-analysis. Statistical analysis was performed using RevMan 5.0 software. Results: There were no significant differences in the final refractive spherical equivalent (p = 0.38), manifest refractive spherical equivalent within ±0.50 D of the target (p = 0.76), final uncorrected visual acuity (p = 0.90), loss of ≧1 line of best spectacle-corrected visual acuity (p = 0.99), and corneal haze at 3 months postoperatively (p = 0.96) or more than 6 months (p = 0.64). More patients felt severe pain in the on-flap group than in the off-flap group, although this finding was not statistically significant (p = 0.05). However, off-flap epi-LASIK had a better mean uncorrected visual acuity at 3 days (p = 0.04) and 5 days (p = 0.01), and faster re-epithelialization (p < 0.00001) after surgery. Conclusions: According to the available data, off-flap and on-flap epi-LASIK had equal visual and refractive outcomes for the treatment of myopia. Off-flap epi-LASIK had more rapid re-epithelialization and visual recovery compared to on-flap epi-LASIK.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Seven studies reported data for postoperative manifest refractive spherical equivalent [7,8,13,15,16,17,18]. Follow-up time ranged from 6 months to 1 year.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies reported data for the proportion of participants within ±0.50 D of target refraction [7,9,14,15,18]. The follow-up time ranged from 3 months to 1 year.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

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A control-matched comparison of flap off and flap on laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia and myopic astigmatism

Tobaigy

2016

Saudi Journal of Ophthalmology

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Comparison of visual outcomes after femtosecond laser-assisted LASIK versus flap-off epipolis LASIK for myopia

2020

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Background: This study clinically evaluated the visual outcomes after refractive surgery for myopia using femtosecond laser-assisted in situ keratomileusis (femto-LASIK) and flap-off epipolis LASIK (epi-LASIK). Methods: In this retrospective case series study, 40 eyes of 27 patients were divided into two groups depending on the technique used for refractive surgery. Femto-LASIK and flap-off epi-LASIK flaps were created using femtosecond laser and Epi-K™ epikeratome, respectively. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity, manifest refraction, corneal asphericity, and corneal higher-order aberrations (HOAs) were assessed pre-and postoperatively. Results: The improvement in logarithm of the minimum angle of resolution (logMAR) UDVA after refractive surgery was statistically significant for both groups (P < 0.001 for all groups); it was significant better in UDVA in femto-LASIK than flap-off epi-LASIK, 0.03 ± 0.06 logMAR (femto-LASIK) and 0.54 ± 0.31 logMAR (flap-off epi-LASIK), at 1 day postoperatively; 0.02 ± 0.05 logMAR (femto-LASIK) and 0.14 ± 0.13 logMAR (flap-off epi-LASIK), at 1 week postoperatively (P < 0.001 and P = 0.019). With regard to the corneal HOAs, the increment in spherical aberration (Z 4,0) was greater in flap-off epi-LASIK than femto-LASIK: 0.626 ± 0.232 μm and 0.479 ± 0.139 μm in the front cornea; 0.556 ± 0.227 μm and 0.430 ± 0.137 μm in the total cornea (P = 0.016 and P = 0.017). However, the back corneal HOA changes did not have a significant effect on the total corneal HOA changes. Conclusion: Femto-LASIK yielded better early visual outcomes than did flap-off epi-LASIK, but there was no significant difference between the outcomes of the two procedures, 1 week postoperatively.

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Wavefront-guided epithelial laser in situ keratomileusis with mitomycin-C for myopia and myopic astigmatism: Flap-on versus flap-off technique

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 11 publications

References 19 publications

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

A control-matched comparison of flap off and flap on laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia and myopic astigmatism

Comparison of visual outcomes after femtosecond laser-assisted LASIK versus flap-off epipolis LASIK for myopia

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