Waveform simulation based on 3D dose distribution for acoustic wave generated by proton beam irradiation

Terunuma, Toshiyuki; Sakae, Takeji; Hayakawa, Yoshinori; Nohtomi, Akihiro; Takada, Yoshihisa; Yasuoka, K.; Maruhashi, Akira

doi:10.1118/1.2767985

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…15,16,19 The only measurement during a therapeutic irradiation 17 was made at conditions, where the entire tumor volume was irradiated at once, requiring also a dose distribution laterally and longitudinally extended over several centimeters with the so-called passive scattering technique. In this scenario, the corresponding ultrasound waves have a complex structure, from which the underlying dose distribution has to be reconstructed, 36 with only limited accuracy for resolving the spread out Bragg peak (SOBP) distribution. A more advanced irradiation technique makes use of active scanning, where a narrow and quasi-monoenergetic proton pencil beam is scanned across the tumor volume with magnetic deflection, adjusting the Bragg peak position in depth by stepwise changes of the proton energy.…”

Section: Discussionmentioning

confidence: 99%

Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy

et al. 2015

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The authors have studied the ionoacoustic signal of the Bragg peak in experiments using a 20 MeV proton beam with its correspondingly localized energy deposition, demonstrating submillimeter position resolution and providing a deep insight in the correlation between the acoustic signal and Bragg peak shape. These results, together with earlier experiments and new simulations (including the results in this study) at higher energies, suggest ionoacoustics as a technique for range verification in particle therapy at locations, where the tumor can be localized by ultrasound imaging. This acoustic range verification approach could offer the possibility of combining anatomical ultrasound and Bragg peak imaging, but further studies are required for translation of these findings to clinical application.

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Section: Discussionmentioning

confidence: 99%

Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy

et al. 2015

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“…Previous protoacoustic measurements have utilized proton sources at dedicated facilities. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Based on the difference between their characteristic proton spills, the protoacoustic pressure amplitude generated by single-bunch synchrotron spills (<1 µs) is expected to be higher than those generated by either clinical cyclotrons, which typically deliver proton spills with ∼50 µs rise and fall times, or clinical synchrotrons, which typically deliver with ∼200 µs rise and fall times. 22 Given the short (<1 µs) spill times and high (up to 100 mA instantaneous 11 ) proton current capabilities, previous observations of the protoacoustic signal have employed linear accelerator, 6 synchrotron, 7-17 and tandem-accelerator 18 proton sources.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Based on the difference between their characteristic proton spills, the protoacoustic pressure amplitude generated by single-bunch synchrotron spills (<1 µs) is expected to be higher than those generated by either clinical cyclotrons, which typically deliver proton spills with ∼50 µs rise and fall times, or clinical synchrotrons, which typically deliver with ∼200 µs rise and fall times. 22 Given the short (<1 µs) spill times and high (up to 100 mA instantaneous 11 ) proton current capabilities, previous observations of the protoacoustic signal have employed linear accelerator, 6 synchrotron, [7][8][9][10][11][12][13][14][15][16][17] and tandem-accelerator 18 proton sources. Protoacoustic signals have also been observed using cyclotron-derived proton beams, 6,19 but these have used custom, modifiable beam lines originally built for research before they were applied to clinical therapy use, and the spill rise times were not reported.…”

Section: Introductionmentioning

confidence: 99%

Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital‐based clinical cyclotron

et al. 2015

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Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 µs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 µs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring. C 2015 American Association of Physicists in Medicine. [http://dx

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“…Using high frequency (up to 10 MHz) ultrasound transducers, we have recently shown one dimensional detection of ionoacoustic signals from a 20 MeV proton Bragg peak 15 . Besides several ionoacoustic simulation studies 16 17 18 , in experiments at an advanced hospital-based cyclotron with 230 MeV protons ionoacoustic signals were observed around 10 kHz with hydrophones 19 . Alsanea et al 20 demonstrated ionoacoustic tomography in simulations, however, no experimental study so far has revealed the spatial characteristics of proton beams.…”

mentioning

confidence: 93%

Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging

Kellnberger

Assmann

Lehrack

et al. 2016

Sci Rep

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Ions provide a more advantageous dose distribution than photons for external beam radiotherapy, due to their so-called inverse depth dose deposition and, in particular a characteristic dose maximum at their end-of-range (Bragg peak). The favorable physical interaction properties enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical use requires accurate monitoring of Bragg peak positioning inside tissue. We introduce ionoacoustic tomography based on detection of ion induced ultrasound waves as a technique to provide feedback on the ion beam profile. We demonstrate for 20 MeV protons that ion range imaging is possible with submillimeter accuracy and can be combined with clinical ultrasound and optoacoustic tomography of similar precision. Our results indicate a simple and direct possibility to correlate, in-vivo and in real-time, the conventional ultrasound echo of the tumor region with ionoacoustic tomography. Combined with optoacoustic tomography it offers a well suited pre-clinical imaging system.

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Waveform simulation based on 3D dose distribution for acoustic wave generated by proton beam irradiation

Cited by 12 publications

References 16 publications

Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy

Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy

Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital‐based clinical cyclotron

Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging

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