Watersoluble polymers in medicine

Abstract

I n s t i t u t e of O r g a n i c C h e m i s t r y , U n i v e r s i t y o f Mainz I FRG * ) W a t e r s o l u b l e P o l y m e r s i n M e d i c i n e H u b e r t B a d e r , Helmut R i n g s d o r f , B r i g i t t a S c h m i d t SUMMARY: * ) E x t e n d e d a b s t r a c t o f a p a p e r p r e s e n t e d a t t h e m e e t i n g o f t h e GDCh-Fachgruppe "Makrornolekulare Chemie" o n '!Polymers a n d

Double-Hydrophilic Block Copolymers: Synthesis and Application as Novel Surfactants and Crystal Growth Modifiers

“…Various applications of DHBCs have been reported for drug delivery purposes, as reviewed in the literature. [171 -173] The first work on such systems was published already in 1984 by Ringsdorf et al [174] Sulfido derivatives of cyclophosphamide, an alkylating antitumor agent, were chemically fixed to PEO-block-PLys, and the block copolymer formed micelles which protected the cyclophosphamide from rapid hydrolysis with the hydrolysis rate strongly depending on the carrier structure. Here the cyclophosphamide acted as an intracellular depot for the active metabolite.…”

“…Here the cyclophosphamide acted as an intracellular depot for the active metabolite. [174] However, especially the antitumor drug adriamycin (ADR), which can be conjugated to PEO-block-PAsp, received considerable attention. The majority of papers about drug delivery based on DHBCs are related to this system.…”

Clonazepam release from core-shell type nanoparticles composed of poly(?-benzylL-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part

“…[1][2][3][4][5][6][7][8][9] posed of a hydrophobic part and a hydrophilic Several problems, such as biodistribution of one is a considerably attracted area. These drug drugs, drug solubility, undesirable side effects, carrier systems with core shell structure have rapid clearance by the reticuloendothelial system predominant characteristics that hydrophobic (RES), thermal instability, short blood circulainner core acts as a drug incorporation site, especially ease entrapment of hydrophobic drugs by hydrophobic interactions 13 and hydrophilic as liver, spleen, lungs, and kidneys and then a hydrophobic block which is a drug incorporation site as the core and has biodegradability 17 and have the potential of long blood circulation times of nanoparticles.…”

Macromolecular Colloids of Diblock Poly(amino acids) That Bind Insulin

“…The solid was filtered, washed, and dried (280 g, 95%). Analysis by 1 H NMR (trifluoroacetic acid-d) gave a Glu/(Leu ϩ Glu) relative amount of 50 mol%: 0.9 -1.1 (0.5 ϫ 6H, Me-Leu), 1.5 (0.5 ϫ 3H, CHand CH 2 -Leu), 2.0 (1H, ␤-CH 2 -Glu), 2.4 (1H, ␤-CH 2 -Glu), 3.0 (2H, ␥-CH 2 -Glu), 3.5 (3H, MeO 2 C-Glu), 4.3 (0.5 ϫ 1H, ␣-CHLeu), 4.5 ppm (1H, ␣-CH-Glu).…”

“…A platelet having a weight-average mass M np ϭ 7 ϫ 10 8 g/mol and a molar composition of 75% of leucine has a central leucine layer whose molar mass is 4.8 ϫ 10 8 g/mol for a mean diameter of 200 nm. The density of crystalline leucine can be estimated at ϳ0.83 g/cm 3 based on the spacing of poly(L-leucine) ␣-helices (1.5 nm 2 ) (46) and the length of the helix (1.5 Å/monomer) (47). Using this, we then calculate the thickness of the leucine core of the platelets to be nearly 20 nm.…”