Water-soluble photoluminescent fullerene capped mesoporous silica for pH-responsive drug delivery and bioimaging

Abstract

In this paper, a biocompatible and water-soluble fluorescent fullerene (C-TEG-COOH) coated mesoporous silica nanoparticle (MSN) was successfully fabricated for pH-sensitive drug release and fluorescent cell imaging. The MSN was first reacted with 3-aminopropyltriethoxysilane to obtain an amino-modified MSN, and then the water-soluble C with a carboxyl group was used to cover the surface of the MSN through electrostatic interaction with the amino group in PBS solution (pH = 7.4). The release of doxorubicin hydrochloride (DOX) could be triggered under a mild acidic environment (lysosome, pH = 5.0) due to the protonation of C-TEG-COO, which induced the dissociation of the C-TEG-COOH modified MSN (MSN@C). Furthermore, the uptake of nanoparticles by cells could be tracked because of the green fluorescent property of the C-modified MSN. In an in vitro study, the prepared materials showed excellent biocompatibility and the DOX-loaded nanocarrier exhibited efficient anticancer ability. This work offered a simple method for designing a simultaneous pH-responsive drug delivery and bioimaging system.

Self‐Assembled Fullerene Nanostructures: Synthesis and Applications

“…Joshi et al studied the amine functionalized C 60 /MWCNT composite as a nanocarriers for the breast cancer treatment by using methotrexate as a drug. [242] Wang et al [243] and Tan et al [244] have also discussed the use of C 60 with silica as a drug carrier for cancer therapy. The controlled release of drug was also addressed with the help of an off/on state using C 60 for cancer therapy by Shi et al [245] Zhang et al [246] studied the tumor inhibition with murine model using multifunctional C 60 in combination with hyaluronic acid and transferrin based system.…”

Hesperidin: synthesis and characterization of bioflavonoid complex

“…The encapsulation of rutin [14][15][16] and quercetin [17] was proposed as a way to obtain a product with protective effects against oxidative stress. Silica-based materials are suitable for oral delivery of drugs [18][19][20][21][22]. The advantage of silica is the simplicity of chemical modification due the presence of hydroxyl on the inner and outer surface of the material.…”

Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe₃O₄ carbon dots with graphitic black phosphorus quantum dots

“…With the development of nanobiotechnology, it is feasible to design multifunctional nanostructured materials that can simultaneously diagnose and treat cancers via the integration of molecular imaging and therapy technologies. [1][2][3][4][5] The integration of diagnosis and treatment, which can improve the survival rate and quality of life among postoperative patients, has provided an attractive avenue for detecting and treating cancer. Imaging-guided photothermal therapy (PTT), which is a novel therapeutic method of precision therapy, can be used to eliminate residual cancer cells completely with precise guidance in the future.…”