Hesperidin: synthesis and characterization of bioflavonoid complex

Binkowska, Iwona

doi:10.1007/s42452-020-2256-8

Cited by 26 publications

(17 citation statements)

References 29 publications

(32 reference statements)

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“…It was also reported that hesperidin glycosylated form and hesperidin complex has high thermal stability, but pure hesperidin has low thermal stability. These structural differences cannot be detected with the HPLC technique [ 38 ], but they can be distinguished with LC-MS/MS. In this study, we used LC-MS/MS to specifically determine only limonin and hesperidin.…”

Section: Discussionmentioning

confidence: 99%

A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Citrus aurantifolia)

2022

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Green extraction is aimed at reducing energy consumption by using renewable plant sources and environmentally friendly bio-solvents. Lime (Citrus aurantifolia) is a rich source of flavonoids (e.g., hesperidin) and limonoids (e.g., limonin). Manufacturing of lime products (e.g., lime juice) yields a considerable amount of lime peel as food waste that should be comprehensively exploited. The aim of this study was to develop a green and simple extraction method to acquire the highest yield of both limonin and hesperidin from the lime peel. The study method included ethanolic-aqueous extraction and variable factors, i.e., ethanol concentrations, pH values of solvent, and extraction temperature. The response surface methodology was used to optimize extraction conditions. The concentrations of limonin and hesperidin were determined by using UHPLC-MS/MS. Results showed that the yields of limonin and hesperidin significantly depended on ethanol concentrations and extraction temperature, while pH value had the least effect. The optimal extraction condition with the highest amounts of limonin and hesperidin was 80% ethanol at pH 7, 50 °C, which yields 2.072 and 3.353 mg/g of limonin and hesperidin, respectively. This study illustrates a green extraction process using food waste, e.g., lime peel, as an energy-saving source and ethanol as a bio-solvent to achieve the highest amount of double bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Citrus aurantifolia)

2022

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“…Cardiovascular protective effects of hesperidin are expressed in decreasing diastolic blood pressure, glucose levels and various lipid profile parameters, reducing platelet aggregation and increasing in the expression of antioxidative enzymes [74][75][76][77]. Some literature stated that hesperidin also exhibits cardioprotective effect against doxorubicin cardiotoxicity, which is widely used anticancer drug [14,74].…”

Section: Biological Activitiesmentioning

confidence: 99%

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Pyrzyńska

2022

Nutrients

115

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Hesperidin is a bioflavonoid occurring in high concentrations in citrus fruits. Its use has been associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, anti-inflammatory and anticarcinogenic properties. The food industry uses large quantities of citrus fruit, especially for the production of juice. It results in the accumulation of huge amounts of by-products such as peels, seeds, cell and membrane residues, which are also a good source of hesperidin. Thus, its extraction from these by-products has attracted considerable scientific interest with aim to use as natural antioxidants. In this review, the extraction and determination methods for quantification of hesperidin in fruits and by-products are presented and discussed as well as its stability and biological activities.

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“…Hesperidin is a flavanone glycoside found in citrus isolated in 1828 by French chemist Lebreton from the white inner layer of citrus peels (mesocarp, albedo) [ 28 ]. The structure consists of a flavanone aglycone, hesperetin, similar to naringenin, which differs from it for the different pattern of substitution on the B ring, which is functionalized with hydroxy group on 3′ carbon and methoxy group on 4′ carbon, whereas the naringenin lacks the methoxy group ( Figure 13 ) [ 29 ].…”

Section: Chemistrymentioning

confidence: 99%

Polyphenols in the Mediterranean Diet: From Dietary Sources to microRNA Modulation

et al. 2021

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It is now well established that polyphenols are a class of natural substance that offers numerous health benefits; they are present in all plants in very different quantities and types. On the other hand, their bioavailability, and efficacy is are not always well proven. Therefore, this work aims to discuss some types of polyphenols belonging to Mediterranean foods. We chose six polyphenols—(1) Naringenin, (2) Apigenin, (3) Kaempferol, (4) Hesperidin, (5) Ellagic Acid and (6) Oleuropein—present in Mediterranean foods, describing dietary source and their chemistry, as well as their pharmacokinetic profile and their use as nutraceuticals/supplements, in addition to the relevant element of their capability in modulating microRNAs expression profile.

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Hesperidin: synthesis and characterization of bioflavonoid complex

Cited by 26 publications

References 29 publications

A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Citrus aurantifolia)

A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Citrus aurantifolia)

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Polyphenols in the Mediterranean Diet: From Dietary Sources to microRNA Modulation

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