Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Abstract

Hesperidin is a bioflavonoid occurring in high concentrations in citrus fruits. Its use has been associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, anti-inflammatory and anticarcinogenic properties. The food industry uses large quantities of citrus fruit, especially for the production of juice. It results in the accumulation of huge amounts of by-products such as peels, seeds, cell and membrane residues, which are also a good source of hesperidin. Thus, its extraction from these by-products has attracted considerable scientific interest with aim to use as natural antioxidants. In this review, the extraction and determination methods for quantification of hesperidin in fruits and by-products are presented and discussed as well as its stability and biological activities.

Intensifying Effect of Instant Controlled Pressure Drop (DIC) Pre-Treatment on Hesperidin Recovery from Orange Byproducts: In Vitro Antioxidant and Antidiabetic Activities of the Extracts

“…However, the ABTS assay seems most suitable and more appropriate for selecting the radical scavenging activity of the citrus extract. Indeed, the DPPH assay is reported to be less selective for citrus flavonoids because it does not react with flavonoids that do not contain OH groups in the B-ring as well as with aromatic acids [ 10 , 45 ]. PCA ( Table 1 ) confirmed this observation by showing weak correlations between DPPH-RSA values and TPC, TFC, and hesperidin contents.…”

“…The citrus byproduct is an inexpensive source of natural biomass that is widely accessible and particularly rich in phenolic content, which can vary from 0.70 to 19.6 g/100 g of dry matter according to the extraction method and the operating conditions [ 3 ]. Due to their antioxidant properties and capacity to scavenge free radicals, phenolic compounds, particularly flavonoids, have attracted great interest and shown beneficial effects on human health [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Phenolic compounds demonstrated anti-diabetic and hypolipidemic effects by lowering blood glucose and lipid levels.…”

Potential therapeutic use of plant flavonoids in AD and PD

“…Hesperidin (C 28 H 34 O 15 ) (2S)-5-hydroxy-2-(3-hydroxy- 4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside, is a flavonoid present primarily in unripe citrus fruit, like orange, grapefruit, lemon, and tangerine juice [ 85 ]. This natural compound presents potent anti-oxidative activity, exerts neuroprotective effects and could cross the blood–brain barrier properties [ 86 ].…”

Chiral Separation, Configuration Confirmation and Bioactivity Determination of the Stereoisomers of Hesperidin and Narirutin in Citrus reticulata Blanco

“…Flavanone glycosides are mainly found in citrus plants of the family of Rutaceae . For example, hesperidin, naringenin, narirutin, eriocitrin and neohesperidin are the most abundant components in the peel part of fruit, such as orange, grapefruit, sweet and lime, as well as lemon [ 2 , 3 , 4 , 5 , 6 ].…”