Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats

Battochio, Ana Paula Ronquesel; Sartori, Maria Salete; Coelho, Cláudio Antônio Rabello

doi:10.1590/s0102-86502005000300007

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Because the bitter taste of Plectranthus barbatus leaves resembles that of the Chilean Peumus boldus, a Monimiaceae known for its hepatoprotective effects (Speisky and Cassels, 1994), species grown in Brazil are known as false-boldo or Brazilian-boldo, and used in medicinal teas to treat gastrohepatic disorders and intestinal disfunction (Lorenzi and Matos, 2002). Confirming these medicinal effects, we have previously shown that the aqueous extract (AE) of Plectranthus barbatus enhanced the intestinal transit in mice, protected against gastric lesions induced by ethanol or cold-restraint stress, and reduced the total acidity of gastric secretion in pylorus-ligated rats (Fischman et al, 1991;Lapa et al, 1992 hepatoprotective effect was reported in rats with obstructive cholestasis (Battochio et al, 2005).…”

Section: Introductionmentioning

confidence: 80%

Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Schultz¹,

Bossolani²,

Torres³

et al. 2007

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 80%

Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Schultz¹,

Bossolani²,

Torres³

et al. 2007

Journal of Ethnopharmacology

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“…Plectranthus barbatus Andrews is a medicinal plant, popularly known in Brazil as ''Brazilian-boldo" or ''false boldo", frequently used for hepatic protection and in the treatment of gastrointestinal disorders, skin infections, pain, respiratory and genito-urinary diseases (Lorenzi & Matos, 2002;Lukhoba et al, 2006). The hepatoprotective effect of the plant was previously reported in rats with obstructive cholestasis (Battochio, Sartori, & Coelho, 2005).…”

Section: Introductionmentioning

confidence: 99%

Iron chelating-mediated antioxidant activity of Plectranthus barbatus extract on mitochondria

et al. 2010

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a b s t r a c tPlectranthus barbatus Andrews (Lamiaceae) is a popular medicinal plant used to treat gastrointestinal and hepatic ailments. In this work, we assessed the antioxidant activity of the aqueous extract of P. barbatus leaves on Fe 2+ -citrate-mediated membrane lipid peroxidation in isolated rat liver mitochondria, as well in non-mitochondrial systems: DPPH reduction, Å OH scavenging activity, and iron chelation by prevention of formation of the Fe 2+ -bathophenanthroline disulfonic acid (BPS) complex. Within all the tested concentrations (15-75 lg/ml), P. barbatus extract presented significant free radical-scavenging activity (IC 50 = 35.8 ± 0.27 lg/ml in the DPPH Å assay and IC 50 = 69.1 ± 0.73 lg/ml in the Å OH assay) and chelated iron (IC 50 = 30.4 ± 3.31 lg/ml). Over the same concentration range, the plant extract protected mitochondria against Fe 2+ /citrate-mediated swelling and malondialdehyde production, a property that persisted even after simulation of its passage through the digestive tract. These effects could be attributed to the phenolic compounds, nepetoidin -caffeic acid esters, present in the extract. Therefore, P. barbatus extract prevents mitochondrial membrane lipid peroxidation, probably by chelation of iron, revealing potential applicability as a therapeutic source of molecules against diseases involving mitochondrial iron overload.

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“…The water extract of P. barbatus leaves administered by gavage to young rats with and without cholestasis was reported to reduce weight gain, feed ingestion, and energy utilization in both groups in the same proportion. However, the water extract was found to inhibit, partially, the increase in liver wet weight, liver fat content and the serum levels of cholesterol and triacylgycerides caused by cholestasis [16]. Furthermore, P. barbatus extract fed to ovariectomized rats was found to reduce body weight, food intake and fat accumulation [17].…”

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confidence: 99%

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 2

Alasbahi

Melzig²

2010

Planta Med

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Pharmacology ! Plectranthus barbatusStudies on several extracts with various polarities obtained from different parts of P. barbatus revealed a number of pharmacological properties that may justify most of the traditional uses of P. barbatus, for example, organic extracts were reported to possess anti-inflammatory, antimicrobial [1, 2], antioxidant [3], cytotoxic [4], hypotensive [5,6], spasmolytic [7], hepatoprotective [8] and antifeedant [9] activities as well as activity against Ehrlichʼs ascites tumor in mice [10]. An alcoholic extract of the P. barbatus roots was shown to exhibit marked inhibitory action against Escherichia coli toxin-induced secretory response in rabbits and guinea pig ileal loops [11]. It has been shown that a hydroalcoholic extract of P. barbatus (880 mg/kg/day) exerted a variety of toxic effects on the different periods of pregnancy in rats; for example, in the period before embryo implantation, it caused a delay in fetal development and anti-implantation and, after embryo implantation, a delay in the development associated with maternal toxicity [12]. The water extract of P. barbatus leaves was found to exert hypoglycemic, hypotensive and antispasmodic activities [13]. It has been demonstrated that the water extract (WE) of the stems and leaves, at a dose of 1 g/kg p. o., shortened the sleeping time induced by pentobarbital by 37 %, and at a dose of 2 g/kg p. o. enhanced the intestinal transit of charcoal by 30% in mice. The WE (2 g/kg/intraduodenal) also reduced the gastric secretions (3.9 ± 1.0 to 0.5 ± 0.2 mL/4 h), and total acid secretion (34.4 ± 11.0 to 2.7 ± 0.5 mEq/L) and raised gastric pH (2.2 ± 0.3 to 6.5 ± 0.8) in rats. The treatment with WE (2 g/ kg p. o.) was also found to protect against lesions induced by ethanol or cold-restraint stress, in pylorus-ligated rats [14]. Similar results were obtained by Schultz et al. [15] who reported that the WE of the leaves (0.5-0.1 g/kg) injected into the duodenal lumen decreased the volume (62 and 76 %) and total acidity (23 and 50%) of gastric Abstract ! Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L′ Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractive target for intensive chemical and pharmacological studies up to now. This review presents data about the phytochemistry, ethnobotanical uses and pharmacology of Plectranthus barbatus as well as the pharmacology of its constituents. In addition to essential oil, abietane diterpenoids and 8,13-epoxy-labd-14-en-11-one diterpenoids are the main constituents found in Plectranthus barbatus. The major ethnobotanical uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain nervous system disorders. Forskolin as one of the major constituents with its unique adenylyl cyclase activation that underlies the wide range of pharmacologic...

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Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats

Abstract: Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosisan experimental study in young rats

Cited by 5 publications

References 21 publications

Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Iron chelating-mediated antioxidant activity of Plectranthus barbatus extract on mitochondria

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 2

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