Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Schultz, Carla S.; Bossolani, Myllene P.; Torres, Luce Maria Brandão; Lima‐Landman, Maria Teresa R.; Lapa, Antônio José; Souccar, Caden

doi:10.1016/j.jep.2006.09.046

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…Many studies (Ooshima et al, 2000;Taguri, Tanaka, & Kuono, 2004;Moreno, Scheyer, Romano, & Vojnov, 2006) have identified phenolic compounds isolated from medicinal plants, like teas and other beverages with antimicrobial properties against mutans streptococci. In this context and taking into account that previous studies reported that P. barbatus, P. ecklonii aqueous extracts and rosmarinic acid, have shown a wide variety of pharmalogical effects on enzymes such as acetylcholinesterase (Falé et al, 2009) and gastric H + , K + -ATPase (Schultz et al, 2007). In this study we examined the potential activity of these plants extracts and of rosmarinic acid against S. mutans and S. sobrinus.…”

Section: Discussionmentioning

confidence: 99%

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

et al. 2010

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Section: Discussionmentioning

confidence: 99%

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

et al. 2010

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“…Plants such as 'capim cidreira' and 'hortelã' are known in various parts of the world and are consumed for relaxation (Cruz, 1985), this was also observed in this study. Moreover, at least three more species present in the interviewees' diet are endowed with scientifically proven pharmacological properties: 'capim cidreira' (Onawunmi et al, 1984;Blanco et al, 2009), 'guaco' (Moura et al, 2002) and 'boldo' (Schultz et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Contributions of the old urban homegardens for food production and consumption in Rio Claro, Southeastern Brazil

Eichemberg

Amorozo

2013

Bol. Mus. Para. Emílio Goeldi. Ciênc. hum.

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Urban homegardens are green areas of households within the city limits and they have the potential to provide families with a cheap alternative for diet improvement, and to complement the income of the families who sell cultivated products. This research analyzes the contributions of old urban homegardens on food consumption and household economy. Data related to homegardens composition were collected by interviews and by collecting cultivated plants.Diets were assessed through a retrospective method (last 24 hours food recall) and administered every two months, during a year, to include seasonal variations. The diet of the sampled population was found to be dependent on certain foods, indicating a narrow food niche (Levins index = 25.9; Levins standardized index = 0.23). Variations in interviewees' diet are related to the consumption of fruits and vegetables, which are partly supplied by homegardens. Spices and teas consumed were obtained from homegardens, revealing its importance in food consumption and health. Among the 98 species found in homegardens, only 38% appeared in the interviewees' diet, indicating an under-exploitation of these homegardens. Our study found that the main role of homegardens is to supply variation in the diet, contributing to the consumption of different types of products.Keywords: Diet. Ethnobotany. Food niche. Urban agriculture.Resumo: Os quintais urbanos correspondem às áreas verdes domiciliares dentro dos limites urbanos e têm o potencial de fornecer às famílias uma alternativa barata para a melhoria da dieta e complementação da renda familiar, pela venda de itens produzidos nesse espaço. Este estudo analisa a contribuição dos quintais urbanos antigos na alimentação e na economia doméstica. Os dados sobre a composição dos quintais foram obtidos por meio de entrevistas e pela coleta de plantas presentes nos quintais. As dietas foram levantadas pelo método recordatório das últimas 24 horas, aplicado bimensalmente, durante um ano, para incluir variações sazonais. Verificou-se que a dieta da população amostrada é dependente de alguns alimentos, indicando um nicho alimentar estreito (índice de Levins = 25,9; Levins padronizado = 0,23). As variações nas dietas dos informantes estão relacionadas com o consumo de frutas e hortaliças, em parte fornecidas pelo quintal. Temperos e chás consumidos foram obtidos dos quintais, revelando sua importância para alimentação e saúde. Das 98 espécies alimentares encontradas nos quintais, apenas 38% apareceram na dieta dos entrevistados, indicando uma subexploração dos quintais. Em nosso estudo, a principal função relatada para os quintais foi proporcionar variações da dieta, contribuindo para o consumo de itens diversificados.Palavras-chaves: Dieta. Etnobotânica. Nicho alimentar. Agricultura urbana.

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“…For stomachache and as purgative in Kenya and for nausea in Southern Uganda [1,74]. In Brazil, as a substitute for boldo (Peumus boldus) to treat gastric disturbances (e.g., gastritis and intestinal spasms) and hepatic disorders [1,3,29,75]. Teeth and gum disorders [1].…”

Section: Non-medicinal Usesmentioning

confidence: 99%

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Alasbahi

Melzig

2010

Planta Med

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Plectranthus L′ Herit., is a complex genus of the family Lamiaceae (Labiatae) that contains about 300 species distributed in tropical Africa, Asia and Australia [1]. Taxonomically the genera Coleus and Plectranthus are recombined by the Japanese authors to the genus Plectranthus [2]. One of the most important species of this genus is Plectranthus barbatus Andr., which is commonly referred to by a number of synonyms such as Plectranthus forskohlii Briq, Plectranthus forskalaei Willd., Plectranthus kilimandschari (Gürke) H. L. Maass., Plectranthus grandis (Cramer) R. H. Willemse, Coleus forskohlii Briq., Coleus kilimandschari Gürke ex Engl., Coleus coerulescens Gürke, Coleus comosus A. Rich., and Coleus barbatus (Andr.) Benth [1]. Plectranthus barbatus grows perennially over the tropical and subtropical regions of the Indian subcontinent and is cultivated commercially for its use in pickles. It is also distributed over parts of Pakistan, Sri Lanka, tropical East Africa, Asia (South of Arabian Peninsula, China) and Brazil [3-5]. P. barbatus is one of the most commonly used medicinal species of the genus Plectranthus. A diversity of traditional medicinal uses of P. barbatus in India (Hindu and Ayurvedic medicine), East and Central Africa, China, and Brazil have been reported. The majority of uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain central nervous system disorders [1, 3, 4, 6, 7]. P. barbatus root extracts, such as the 50% ethanolic and methanolic extracts were therefore, in the middle of the 1970s, independently involved in screening programs for biological activities such as cardiovascular properties in the Central Drug Research Institute (CDRI), Lucknow, India, and by the group at Hoechst India Limited in Bombay, India. Reports from both research groups revealed the hypotensive and antispasmodic effects of the root extracts as well as the isolation of the major active principle which was named coleonol by CDRI [

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Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Cited by 22 publications

References 31 publications

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

Contributions of the old urban homegardens for food production and consumption in Rio Claro, Southeastern Brazil

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

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