Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity

Antifungal Potential of Copper(II), Manganese(II) and Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming the Candida haemulonii Complex: Impact on the Planktonic and Biofilm Lifestyles

“…The following metal chelates were prepared using previously published methods: [Cu(ph)(phen)(H 2 O) 2 ] ( 1 ) (phH 2 = phthalic acid) (Kellett et al, 2012); [Cu(ph)(phen) 2 ].3H 2 O.2EtOH ( 2 ) (Kellett et al, 2011); [Cu(isoph)(phen) 2 ].6H 2 O.EtOH ( 3 ) (isophH 2 = isophthalic acid) (Kellett et al, 2011); [{Cu(phen) 2 } 2 (terph)](terph).13.5H 2 O.2EtOH ( 4 ) (terphH 2 = terephthalic acid) (Kellett et al, 2011); [Cu 2 (oda)(phen) 4 ](ClO 4 ) 2 .2.76H 2 O.EtOH ( 5 ) (odaH 2 = octanedioic acid) (Devereux et al, 1999); [Cu(phendione) 3 ](ClO 4 ) 2 .4H 2 O ( 6 ) (phendione = 1,10-phenanthroline-5,6-dione) (McCann et al, 2004); [Mn(ph)(phen)(H 2 O) 2 ] ( 8 ) (Devereux et al, 2000); [Mn(ph)(phen) 2 (H 2 O)].4H 2 O ( 9 ) (Devereux et al, 1999); [Mn 2 (isoph) 2 (phen) 3 ].4H 2 O ( 10 ) (Devereux et al, 2000); {[Mn(phen) 2 (H 2 O) 2 ]} 2 (isoph) 2 (phen).12H 2 O ( 11 ) (Devereux et al, 2000); [Mn(tereph)(phen) 2 ].5H 2 O ( 12 ) (Leon, 2000); [Mn 2 (oda)(phen) 4 (H 2 O) 2 ][Mn 2 (oda)(phen) 4 (oda) 2 ].4H 2 O ( 13 ) (Casey et al, 1994); {[Mn(3,6,9-tdda)(phen) 2 ].3H 2 O.EtOH} n ( 14 ) (3,6,9-tddaH 2 = 3,6,9-trioxaundecanedioic acid) (McCann et al, 1997); [Ag(phendione) 2 ]ClO 4 ( 15 ) (McCann et al, 2004); [Ag(phen) 2 ]ClO 4 ( 17 ) (McCann et al, 2004) and [Ag 2 (phen) 3 (udda)].3H 2 O ( 18 ) (uddaH 2 = undecanedioic acid) (Thornton et al, 2016). The novel complexes, {[Cu(3,6,9-tdda)(phen) 2 ].3H 2 O.EtOH} n ( 7 ) and [Ag 2 (3,6,9-tdda)(phen) 4 ].EtOH ( 16 ), were synthesized using the two-step procedures outlined below.…”

Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation

“…Full analytical and IR, 1 H, 13 C NMR and UV-Vis spectroscopic data are presented in Section S3, Supplementary material with selected data for representative complexes given in Table S8 and Tables 3-6. 2.2.3. Synthesis of 1,10-phenanthroline adducts of silver(I) complexes of 2-(2-oxo-2H-chromen-substituted-yl)oxy acetic acid-based ligands (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) A literature method was adopted for the synthesis of these adducts [21]. All of the following reactions were carried out under dark conditions to obtain suitable complexes for structure elucidation studies.…”

“…All of the following reactions were carried out under dark conditions to obtain suitable complexes for structure elucidation studies. The experimental data recorded for phen adducts (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) are given in Section S4 in Supplementary material with selected data for representative complexes given in Tables 3-6.…”

“…We have recently reported a series of water-soluble and photo-stable silver(I) dicarboyxlate complexes with excellent antimicrobial activity and anticancer activity. Interestingly these complexes appeared to have a different mechanism of action to other silver(I) compounds in that they did not induce deoxyribonucleic acid (DNA) damage or reactive oxygen species (ROS) generation and in fact seemed to act as antioxidants in the systems studied, significantly reducing superoxide and hydrogen peroxide induced oxidative stress in the yeast S. cerevisiae [37].…”

Heteroleptic complexes of antifungal drugs with the silver ion

“…Some Ag(I) ternary complexes where one of the ligands is phen are curious because of the two different environments that surround the metal centers 24b,46 . Among these, some silver(I) dicarboxylate complexes containing 1,10‐phenanthroline ligands, [Ag(phen) 3 (OOC–(CH 2 )y–COO)] · zH 2 O (y = 1–10; z = 1–4), whose proposal structure exposes one silver center bonded to one molecule of phen and the another silver center bonded to two molecules of phen, both silver ions bridged by the dicarboxilate moiety . A similar structure might be suggested for the complex Ag–albz–phen, acting the albz moiety as a bridge between the two silver centers, coordinating with one Ag(I) by mean of the N atom of benzimidazole and the O atom of the carbonyl group and with the another Ag(I) center by the S atom.…”