This paper provides guidance on when and where relativepermeability-modification/disproportionate-permeability-reduction (RPM/DPR) water-shutoff (WSO) treatments can be successfully applied for use in either oil or gas production wells. When properly designed and executed, these treatments can be successfully applied to a limited range of oilfield excessive-water-production problems. When these treatments are applicable, they may be placed using bullhead injection (not requiring mechanical zone isolation)-a very favorable feature. However, there are a substantial number of limitations and possible pitfalls relating to the successful application of RPM/DPR WSO treatments. First-time application by an inexperienced operator should be considered a somewhat high-risk undertaking. In order to successfully treat unfractured production wells (i.e., radial flow through matrix rock into the well) that are fully drawn down, the oil and water zones should not be in pressure communication and the oil-producing zone(s) must be producing at 100% oil cut (dry oil). When treating unfractured and multizoned production wells that are not fully drawn down, the well's long-term oil-production rate can be increased if the post-treatment drawdown is increased substantially. Treatments that promote short-term (transient) decreased water/oil ratios can, in principle, be applied to many unfractured production wells (that are not totally watered out) in matrix-rock reservoirs. However, these latter treatments must be custom designed and engineered on a well-by-well basis. Furthermore, for most wells, the performance and the economics of such transient WSO treatments are generally marginal. An attractive application of RPM/ DPR WSO treatments is the use of robust pore-filling gels in the matrix reservoir rock that is adjacent to a fracture(s) when oil and water is being co-produced into the treated fracture. Zitha et al. 1999;Al-Sharji et al. 1999;Elmkies et al. 2001;Stavland and Nilsson 2001;Grattoni et al. 2001;Seright et al. 2002;Willhite et al. 2002). More recently, a plausible mechanism was proposed that explains how chromium(III)-carboxylate/acrylamidepolymer (CC/AP) gels impart DPR (Seright et al. 2006). A detailed discussion of the mechanism by which water-soluble polymers and aqueous polymer gels impart RPM/DPR is beyond the scope of this paper. Historically, a large number of ineffective, underperforming, and/or disappointing RPM/DPR water-shutoff treatments were applied by the petroleum industry (Eoff et al.