Water promoted one pot three-component synthesis of tetrazoles

One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles

“…The reaction sequence involved the formation of thioureas 12. In contrast to the previously mentioned work of Ponnuswamy and colleagues (Scheme 1C), 38 our protocol did not involve desulfurization of 12 but instead included their conversion to S-alkylisothiourea intermediates 13. After the alkylation of 12 with 1,3-propane sultone 14, excess of 14 and acidic sulfonate was quenched by adding NEt 3 .…”

“…However, poor availability of the isocyanide reagents dramatically limits the scope of this method. A one-pot three-component procedure developed by Ponnuswamy and colleagues, which used isothiocyanates, amines, and NaN 3 as the starting materials, might be a more plausible method (C) . Nevertheless, utilization of HgCl 2 for the desulfurization step is undesirable because of the toxicity of mercury contaminants.…”

Synthesis and study antimicrobial activities of some novel Tetrazole derivatives

“…are considered as bioisosteres of cis amides and carboxylic acids in medicinal chemistry with higher liphophilicity [14]. Although tetrazoles and their derivatives rarely occur in nature [15] the clear majority show biological activity [16]. Among them, 5-aminotetrazoles ( Fig.…”

A Smart and Efficient One‐Pot Green Synthesis of Novel 1, 2, 3‐Triazolyl Pyrazoline‐/Indazolyl‐Carbothioamide Hybrids under Solvent‐Free Grinding Strategy at Room Temperature

“…In view of the above and as part of our ongoing research platform on the eco‐friendly syntheses of biologically important heterocyclic/hybrid heterocyclic compounds under solvent‐free, and aqueous conditions, herein, we report a smart and efficient green synthesis of novel 1, 2, 3‐triazolyl pyrazoline‐/indazolyl‐carbothioamide hybrids from the sequential reactions of ketones, aldehydes, hydrazine hydrate and aryl isothiocyanates under one‐pot, solvent‐free grinding strategy at room temperature.…”