Water movements in the brain: role of aquaporins

Tait, Matthew; Saadoun, Samira; Bell, B. Anthony; Papadopoulos, Marios C.

doi:10.1016/j.tins.2007.11.003

Cited by 309 publications

(277 citation statements)

References 67 publications

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“…Water channel AQP4 is the predominant aquaporin in the CNS, and is abundantly expressed in the brain and spinal cord in perimicrovessel astrocyte foot processes, the glia limitans, and ependyma (Rash et al, 1998;Oshio et al, 2004;Vajda et al, 2004). AQP4 plays an important role in brain edema, astrocyte migration, and neuronal excitability (Tait et al, 2008). As water movement through AQP4 is bidirectional, there is a potential role in resolution of brain edema.…”

Section: Discussionmentioning

confidence: 99%

“…The increased expression of AQP4 was not an early event, but rather occurred later in the course of EAE, either during progression of the subclinical EAE or the development of clinical EAE. AQP4 was suggested to worsen cytotoxic edema (cell swelling) (Manley et al, 2000;Papadopoulos et al, 2005) and ameliorate vasogenic edema (vessel leak) (Papadopoulos et al, 2004;Bloch et al, 2005;Bloch et al, 2006;Tait et al, 2008). Vasogenic edema primarily results from the disruption of barrier function and subsequent accumulation of water into the extracellular space.…”

Section: Discussionmentioning

confidence: 99%

“…There is now compelling evidence that aquaporin 4 (AQP4), the predominant aquaporin in the CNS, is functionally active (Amiry-Moghaddam et al, 2003;Nicchia et al, 2003;Solenov et al, 2004), and is implicated in the CNS diseases including brain edema, astrocyte migration, and neuronal excitability (Tait et al, 2008). Although the role of AQP4 in edema has been extensively investigated, there is little information on its functional role at the BBB and BSCB.…”

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confidence: 99%

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The Relationship Between Aquaporin‐4 Expression and Blood‐Brain and Spinal Cord Barrier Permeability Following Experimental Autoimmune Encephalomyelitis in the Rat

Huang

Wang

et al. 2010

The Anatomical Record

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Aquaporin 4(AQP4) is a water channel protein strongly expressed in the central nervous system in perimicrovessel astrocyte foot processes, the glia limitans, and ependyma. Expression of AQP4 is highest at the bloodbrain barrier and blood-spinal cord barrier, supporting its critical function in material transport across these structures. Recently, presence of the anti-aquaporin-4 antibody in sera has been used as an important diagnostic tool for neuromyelitis optica, suggesting a potential role in central nervous system inflammation. The aim of the present study was to examine AQP4 protein expression in the cerebellum and spinal cord from rats with experimental autoimmune encephalomyelitis. By western blot analysis, AQP4 expression increased during experimental autoimmune encephalomyelitis development, and peaked at onset (lumbar enlargement) or climax (cerebellum) of neurological signs of experimental autoimmune encephalomyelitis. There was also a faster and more pronounced increase in permeability in the cerebellar blood-brain barrier and the lumbar enlargement blood-spinal cord barrier consistent with AQP4 expression, which was manifested by increased Evans Blue leakage and reduced tight junction protein expression. In conclusion, aquaporin upregulation may be involved in the development of inflammation in the acute phase of experimental autoimmune encephalomyelitis, and may correlate with damage to central nervous system barrier function. Anat Rec, 294:46-54, 2011. V V C 2010 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Relationship Between Aquaporin‐4 Expression and Blood‐Brain and Spinal Cord Barrier Permeability Following Experimental Autoimmune Encephalomyelitis in the Rat

Huang

Wang

et al. 2010

The Anatomical Record

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“…AQP4 is the predominant water channel in the CNS (Tait et al, 2008). It is expressed at high concentrations in astrocyte foot processes facing microvessels, interneuronal synaptic junctions, and ventricular ependyma.…”

Section: Acute Inflammatory Myelopathies 637mentioning

confidence: 99%

Acute inflammatory myelopathies

Cree

2014

Handbook of Clinical Neurology

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“…In the past two decades, studies on the expression and function of AQPs in the nervous system have been focused mainly in the central nervous system. Numerous studies reported the localization of six AQPs including AQP1, AQP3, AQP4, AQP5, AQP8, and AQP9 in the brain and spinal cord [3] . Functional studies using transgenic knockout mouse model revealed important roles of AQP1 in cerebral spinal fluid (CSF) secretion and pain sensation and AQP4 in brain edema formation, neuronal transduction, neurogenesis, glioma spreading, neuroinfl ammation and pain perception [3][4][5][6][7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Expression and function of aquaporins in peripheral nervous system

Gao

Fang

et al. 2011

Acta Pharmacol Sin

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The expression and role of the aquaporin (AQP) family water channels in the peripheral nervous system was less investigated. Since 2004, however, signifi cant progress has been made in the immunolocalization, regulation and function of AQPs in the peripheral nervous system. These studies showed selective localization of three AQPs (AQP1, AQP2, and AQP4) in dorsal root ganglion neurons, enteric neurons and glial cells, periodontal Ruffi ni endings, trigeminal ganglion neurons and vomeronasal sensory neurons. Functional characterization in transgenic knockout mouse model revealed important role of AQP1 in pain perception. This review will summarize the progress in this fi eld and discuss possible involvement of AQPs in peripheral neuropathies and their potential as novel drug targets.

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Water movements in the brain: role of aquaporins

Cited by 309 publications

References 67 publications

The Relationship Between Aquaporin‐4 Expression and Blood‐Brain and Spinal Cord Barrier Permeability Following Experimental Autoimmune Encephalomyelitis in the Rat

The Relationship Between Aquaporin‐4 Expression and Blood‐Brain and Spinal Cord Barrier Permeability Following Experimental Autoimmune Encephalomyelitis in the Rat

Acute inflammatory myelopathies

Expression and function of aquaporins in peripheral nervous system

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