Acute inflammatory myelopathies

Cree, Bruce A.C.

doi:10.1016/b978-0-444-52001-2.00027-3

Cited by 26 publications

(12 citation statements)

References 352 publications

(413 reference statements)

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“…MS patients show a wide variety of neurological symptoms, including paresthesia or numbness, motor weakness, incoordination, gait disturbance, and cognitive impairment (Cree, 2014; Miller and Leary, 2007; Milo and Miller, 2014). As seen in humans, certain behavioral changes can be observed in EAE mice (Acharjee et al, 2013; Franco-Pons et al, 2007; Jones et al, 2008; Legroux and Arbour, 2015; Moore et al, 2014; Serra-de-Oliveira et al, 2015; Ulrich et al, 2010; Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Intracranial delivery of interleukin-17A via adeno-associated virus fails to induce physical and learning disabilities and neuroinflammation in mice but improves glucose metabolism through AKT signaling pathway

Yang

Kou

Lim

et al. 2016

Brain, Behavior, and Immunity

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Interleukin-17A (IL-17A) is generally considered as one of the pathogenic factors involved in multiple sclerosis (MS). Indirect evidence for this is that IL-17A-producing T helper 17 (Th17) cells preferentially accumulate in lesions of MS and experimental autoimmune encephalomyelitis (EAE). However, a direct involvement of IL-17A in MS pathogenesis is still an open question. In this study, we overexpressed IL-17A in the brains of mice (IL-17A-in-Brain mice) via recombinant adeno-associated virus serotype 5 (rAAV5)-mediated gene delivery. In spite of high levels of IL-17A expression in the brain and blood, IL-17A-in-Brain mice exhibit no inflammatory responses and no abnormalities in motor coordination and spatial orientation. Unexpectedly, IL-17A-in-Brain mice show decreases in body weight and adipose tissue mass and an improvement in glucose tolerance and insulin sensitivity. IL-17A enhances glucose uptake in PC12 cells by activation of AKT. Our results provide direct evidence for the first time that IL-17A overexpression in the central nervous system does not cause physical and learning disabilities and neuroinflammation and suggest that IL-17A may regulate glucose metabolism through the AKT signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Intracranial delivery of interleukin-17A via adeno-associated virus fails to induce physical and learning disabilities and neuroinflammation in mice but improves glucose metabolism through AKT signaling pathway

Yang

Kou

Lim

et al. 2016

Brain, Behavior, and Immunity

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show abstract

“…2 The syndrome points towards a partial cervical myelopathy with only 1 of the 3 main spinal cord pathways affected (sensory, specifically dorsal column, but not motor or bowel/bladder), as opposed to a true transverse myelopathy. 6 …”

Section: Differential Diagnosismentioning

confidence: 99%

A young man with numbness in arms and legs

Romeo

Lisak

Meltzer³

et al. 2018

Neurol Neuroimmunol Neuroinflamm

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“…Rare cases of "poliomyelitis" have been described in Chikungunya virus and in Japanese encephalitis. Completely different -from a direct viral invasion into the myelon -is the post-or parainfectious myelitis which frequently presents as a transverse myelitis (Cree 2014 ;Roman 2014 ;Tyler 2014 …”

Section: Viral Myelitismentioning

confidence: 99%